The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants
Open accessAbstract
Objective To investigate the outcomes following prolonged empirical antibiotic administration to premature infants in the first week of life, concluding subsequent late onset sepsis (LOS), necrotizing enterocolitis (NEC), and death. Study design Study infants were ≤32 weeks gestational age and ≤ 1500 grams birth weight who survived free of sepsis and NEC for 7 days. Multivariable logistic regression was conducted to determine independent relationships between prolonged initial empirical antibiotic therapy (≥ 5 days) and study outcomes controlling for birth weight, gestational age, race, prolonged premature rupture of membranes, days on high frequency ventilation in 7 days, and the amount of breast milk received in the first 14 days of life. Results Of the 365 premature infants surviving 7 days free of sepsis or NEC, 36% received prolonged initial empirical antibiotics, which was independently associated with subsequent outcomes: LOS (odds ratio [OR] 2.45, 95% confidence interval [CI] 1.28–4.67) and the combination of LOS, NEC, or death (OR 2.66, 95% CI 1.12–6.3). Conclusions Prolonged administration of empirical antibiotics to premature infants with sterile cultures in the first week of life is associated with subsequent severe outcomes. Judicious restriction of antibiotic use should be investigated as a strategy to reduce severe outcomes for premature infants.
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Cites
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
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Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates
Bin-Nun, A., Bromiker, R., Wilschanski, M., Kaplan, M., Rudensky, B., Caplan, M., & Hammerman, C. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.03.054 · Cited by 590
Consumption of human milk oligosaccharides by gut-related microbes
Marcobal, A., Barboza, M., Froehlich, J. W., Block, D. E., German, J. B., Lebrilla, C. B., & Mills, D. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9044205 · Cited by 568
Yoshioka, H., Iseki, K.-I., & Fujita, K. (1983) · PEDIATRICS · doi:10.1542/peds.72.3.317 · Cited by 516
Lin, H.-C., Hsu, C.-H., Chen, H.-L., Chung, M.-Y., Hsu, J.-F., Lien, R.-I., Tsao, L.-Y., Chen, C.-H., & Su, B.-H. (2008) · Pediatrics · doi:10.1542/peds.2007-3007 · Cited by 506
Cited by
Deshmukh, H. S., Liu, Y., Menkiti, O. R., Mei, J., Dai, N., O'Leary, C. E., Oliver, P. M., Kolls, J. K., Weiser, J. N., & Worthen, G. S. (2014) · Nature Medicine · doi:10.1038/nm.3542 · Cited by 579
The effect of antibiotics on the composition of the intestinal microbiota—a systematic review
Zimmermann, P., & Curtis, N. (2019) · Journal of Infection · doi:10.1016/j.jinf.2019.10.008 · Cited by 383
Gut microbial colonisation in premature neonates predicts neonatal sepsis
Madan, J. C., Salari, R. C., Saxena, D., Davidson, L., O'Toole, G. A., Moore, J. H., Sogin, M. L., Foster, J. A., Edwards, W. H., Palumbo, P., et al. (2012) · Archives of Disease in Childhood - Fetal and Neonatal Edition · doi:10.1136/fetalneonatal-2011-301373 · Cited by 340
Bacterial Meningitis in Infants
Ku, L. C., Boggess, K. A., & Cohen-Wolkowiez, M. (2015) · Clinics in Perinatology · doi:10.1016/j.clp.2014.10.004 · Cited by 268
Dysbiosis anticipating necrotizing enterocolitis in very premature infants
Sim, K., Shaw, A. G., Randell, P., Cox, M. J., McClure, Z. E., Li, M.-S., Haddad, M., Langford, P. R., Cookson, W. O. C. M., Moffatt, M. F., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu822 · Cited by 224
Metadata
- Authors
- Kuppala, V. S., Meinzen-Derr, J., Morrow, A. L., & Schibler, K. R.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 159
- Issue
- 5
- Pages
- 720-725
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1978213978
- Cited by
- 613
- References
- 6
- FWCI
- 24.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Kuppala, V. S., Meinzen-Derr, J., Morrow, A. L., & Schibler, K. R. (2011). Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2011.05.033
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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