Cited by 63Cardiovascular Effects of ExerciseConnective tissue disorders researchAortic Disease and Treatment Approaches

Exercise and sports participation in patients with thoracic aortic disease: a review

Thijssen, Carlijn G. E., Bons, Lidia R., Gökalp, Arjen L., Van Kimmenade, Roland R. J., Mokhles, Mostafa M., Pelliccia, Antonio, Takkenberg, Johanna J. M., Roos-Hesselink, Jolien W.·2019·Expert Review of Cardiovascular Therapy

Abstract

INTRODUCTION: Current guidelines recommend patients with thoracic aortic disease (TAD) including inherited aortopathies to avoid heavy exercise. However, evidence supporting the negative advice on exercise is scarce. We aimed to provide an up-to-date systematic review of the available evidence on risks and benefits of exercise and sports participation in TAD patients. Areas covered: A systematic search was performed in Medline, Embase and Web of Science: thoracic aortic aneurysm or thoracic aortic dissection or inheritable aortopathies including Marfan Syndrome (MFS), Loeys-Dietz syndrome, Turner Syndrome, Ehlers-Danlos syndrome, bicuspid aortic valve (BAV) and sports, exercise or athletes. The resulting 1,652 manuscripts were reviewed by two independent observers. Eventually, 26 studies and 12 case-reports were included, reporting on thoracic aortic dimensions in athletes, exercise related acute aortic dissections, and exercise in BAV and MFS patients. Expert opinion: Blood pressure elevation during exercise may be associated with an increased risk of acute aortic dissection; however, no controlled trials have longitudinally evaluated the effect of exercise on survival or the risk of aortic dissection in TAD patients. Mouse-model studies suggest beneficial effects of exercise in the setting of a dilated aorta in MFS. There is a clear need for prospective research in this field.

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Crossref · 10.1080/14779072.2019.1585807

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Authors
Thijssen, C. G. E., Bons, L. R., Gökalp, A. L., Van Kimmenade, R. R. J., Mokhles, M. M., Pelliccia, A., Takkenberg, J. J. M., & Roos-Hesselink, J. W.
Affiliations
  • Erasmus MC (NL)
  • Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands
  • Department of Cardiology, Institute of Sports Medicine & Science, Rome, Italy
  • Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Venue
Expert Review of Cardiovascular Therapy
Published
2019-03-21
Volume
17
Issue
4
Pages
251-266
ISSN
  • 1477-9072 (ISSN-L)
  • 1744-8344
OpenAlex
W2924682895
Cited by
63
References
69
Citations by year
2026: 8 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 1
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Cardiovascular Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • Hartstichting (2013T093)
  • ZonMW (84920001)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
Keywords
thoracic aortic disease, physical activity, sports participation, thoracic aortic aneurysm, acute aortic dissection, Marfan syndrome, Loeys-Dietz syndrome, Turner syndrome, Ehlers-Danlos syndrome, bicuspid aortic valve
MeSH terms
Animals, Aorta, Thoracic, Aortic Diseases, Disease Models, Animal, Humans, Sports, Exercise, Risk Assessment, Mice

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