A new phytoecdysteroid from the roots of Achyranthes bidentata Bl.
Abstract
A new phytoecdysteroid compound, named Niuxixinsterone D (1), together with two known phytoecdysteroid compounds (2 and 3) were isolated from Achyranthes bidentata Bl.. The structure of the new compound was elucidated by extensive spectral analysis, including HR-ESI-MS, 1D and 2D NMR methods. Compounds 1-3 were tested for their inhibitory effects against LPS-induced NO production in RAW 264.7 macrophages, and compound 1 and 3 exhibited anti-neuroinflammatory activity with inhibited 29.7 and 26.0% NO production.
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Niuxixinsterone D and serfurosterone A inhibited LPS-induced NO production in RAW 264.7 macrophages by 29.7% and 26.0%, respectively.
“Niuxixinsterone D and serfurosterone A showed anti-neuroinflammatory activity by inhibiting NO production by 29.7% and 26.0%, respectively47.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [47]
The PE niuxixinsterone D shows inhibitory effects against lipopolysaccharide-associated nitric oxide synthesis in macrophages, showing anti-neuroinflammatory activity by preventing nitric oxide production.
“The PE niuxixinsterone D shows inhibitory effects against lipopolysaccharide-associated nitric oxide synthesis in macrophages. Therefore, it shows anti-neuroinflammatory activity by preventing the production of nitric oxide [141].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [141]
Cites
Zhang, X., Xu, X., Xu, T., & Qin, S. (2014) · Drug Development Research · doi:10.1002/ddr.21170 · Cited by 83 · see citing works
New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus
Sun, Y., & Yasukawa, K. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.04.008 · Cited by 69 · see citing works
Anti-inflammatory and anti-tumour effects of Abies georgei extracts
Yang, X., Zeng, H., Liu, X.-H., Li, S., Xu, W., Shen, Y., Zhang, C., & Zhang, W. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.7.0017 · Cited by 60 · see citing works
Two Triterpene Saponins from Achyranthes bidentata.
Mitaine‐Offer, A., Marouf, A., Hanquet, B. J., Birlirakis, N., & Lacaille‐Dubois, M. (2001) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.49.1492 · Cited by 40 · see citing works
Phytoecdysteroids from the Stem Bark of Vitex doniana and Their Anti-Inflammatory Effects
Ochieng, C. O., Ishola, I. O., Opiyo, S. A., Manguro, L. O. A., Owuor, P. O., & Wong, K. (2012) · Planta Medica · doi:10.1055/s-0032-1327880 · Cited by 33 · see citing works
A new feruloyl tyramine glycoside from the roots of Achyranthes bidentata
Yang, L., Jiang, H., Wang, Q., Yang, B., & Kuang, H. (2012) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(12)60003-x · Cited by 32 · see citing works
Martins, A., Csábi, J., Balázs, A., Kitka, D., Amaral, L., Molnár, J., Simon, A., Tóth, G., & Hunyadi, A. (2013) · Molecules · doi:10.3390/molecules181215255 · Cited by 30 · cited 1× · see citing works
“Moreover, compound 2 was deduced to be the same ecdysteroid compound 29α-(3-methoxy-4-hydroxyphenyl)-20,22-O-methylidene-20-hydroxyecdysone recently reported in the literature (Martins et al. 2013), by comparison of its spectroscopic data with reported values.”
Background26-Hydroxylated Ecdysteroids from Silene viridiflora
Tóth, N., Simon, A., Tóth, G., Kele, Z., Hunyadi, A., & Báthori, M. (2008) · Journal of Natural Products · doi:10.1021/np800139q · Cited by 29 · see citing works
A new feruloyl tyramine glycoside from the roots of Achyranthes bidentata
Yang, L., Jiang, H., Wang, Q., Yang, B., & Kuang, H. (2012) · Chinese Journal of Natural Medicines · doi:10.3724/sp.j.1009.2012.00016 · Cited by 29 · see citing works
Phytoecdysteroids from the Roots of Achyranthes bidentata Blume
Zhang, M., Zhou, Z., Wang, J., Cao, Y., Chen, X., Zhang, W., Lin, L., & Tan, J. (2012) · Molecules · doi:10.3390/molecules17033324 · Cited by 28 · see citing works
Palythoalones A and B, New Ecdysteroids from the Marine Zoanthid Palythoa australiae
Shigemori, H., Sato, Y., Kagata, T., & Kobayashi, J. (1999) · Journal of Natural Products · doi:10.1021/np9803880 · Cited by 26 · see citing works
Three New Phytoecdysteroids Containing a Furan Ring from the Roots of Achyranthes bidentata Bl.
Wang, Q., Yang, L., Jiang, H., Wang, Z.-B., Yang, B., & Kuang, H. (2011) · Molecules · doi:10.3390/molecules16075989 · Cited by 26 · see citing works
The first two ecdysteroids containing a furan ring from Serratula wolffii
Liktor‐Busa, E., Simon, A., Tóth, G., & Báthori, M. (2008) · Tetrahedron Letters · doi:10.1016/j.tetlet.2008.01.074 · Cited by 24 · see citing works
Note: A new phytosterone from Achyranthes bidentata Bl.
Meng, D., Li, X., Wang, J., & Li, W. (2004) · Journal of Asian Natural Products Research · doi:10.1080/102860203100001625094 · Cited by 24 · see citing works
Effect of alcoholic extract of achyranthes bidentata blume on acute and sub acute inflammation
Vetrichelvan, T., & Jagadeesan, M. (2002) · Indian Journal of Pharmacology · Cited by 23 · see citing works
Downeyoside A and B, Two New Sulphated Steroid Glucuronides from the Starfish Henricia downeyae
Palagiano, E., Zollo, F., Minale, L., Paloma, L. G., Iorizzi, M., Bryan, P. J., Clintock, J. M., Hopkins, T., Riou, D., & Roussakis, C. (1995) · Tetrahedron · doi:10.1016/0040-4020(95)00775-4 · Cited by 21 · see citing works
Gao, C. (2003) · Anhui Medical and Pharmaceutical Journal · Cited by 16 · see citing works
Studies on chemical constituents and pharmaceutics activity of Achyranthes bidentata Bl
Li, Y. (2011) · Strait Pharmaceutical Journal · Cited by 5 · see citing works
The triterpenoid saponins in Achyranthes bientata Bl
Xiao-hong, Y. (2005) · Zhongguo yaowu huaxue zazhi · Cited by 5 · see citing works
Study on the acidic triterpenoid saponins of Achyranthes bientata Bl.
Wang, G., Zhou, X., Xiao-hong, Y., & Xu, J. (2004) · Zhongguo yaowu huaxue zazhi · Cited by 5 · see citing works
Kuang, H., & Pharmacodynamic, T. (2012) · Cited by 5 · see citing works
Studies on Steroid Constituents of Achyranthes bientata Bl.
Xu, J.-D. (2006) · Zhōnghuá yàoxué zázhì · Cited by 4 · see citing works
Phytosterone constituents from Achyranthese bidentata Bl.
Li, X. (2006) · Shenyang Yaoke Daxue xuebao · Cited by 4 · see citing works
Flagged first, then by citations
2 of the 25 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
“carthamoides(57), leuzeasterone (47) and (24Z)-29-hydroxy-24(28)-dehydromakisterone C (48) isolated”
BackgroundZhang, L., Shi, X., Huang, Z., Mao, J. J. J., Mei, W., Ding, L., Zhang, L., Xing, R., & Wang, P. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02909-4 · Cited by 66 · see citing works
Arif, Y., Singh, P., Bajguz, A., & Hayat, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158664 · Cited by 50 · see citing works
“Achyranthes bidentata (Amaranthaceae) contains four furanoECs that have been isolated from the ethanolic extract [141].”
BackgroundEcdysteroids: Isolation, Chemical Transformations, and Biological Activity
Savchenko, R. G., Veskina, N. A., Odinokov, V. N., Benkovskaya, G. V., & Parfenova, L. V. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-021-09792-y · Cited by 39 · see citing works
Ma, D., Li, Y., Xiao, W. L., Peng, L., Wang, L., Liao, Z., & Hu, L. (2020) · PubMed Central · Cited by 19 · see citing works
RetractedKang, C., Zhao, D., Kang, L., Wang, S., Lv, C., Zhou, L., Jiang, J., Yang, W.-Z., Li, J., Huang, L., et al. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00790 · Cited by 17 · see citing works
Yang, L., Jiang, H., Yan, M., Xing, X., Guo, X., Yang, B., Wang, Q., & Kuang, H. (2018) · Molecules · doi:10.3390/molecules23040758 · Cited by 13 · see citing works
Yang, L., Jiang, H., Yan, M., Xing, X., Guo, X., Man, W., Hou, A., Yang, B., Wang, Q., & Kuang, H. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1579946 · Cited by 11 · see citing works
Romashov, L. V., Kucherov, F. A., Kozlov, K. S., & Ananikov, V. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043997 · Cited by 8 · see citing works
Ying-Ying, W. A. N. G., Jia-Yuan, L. I., Yao, C., ZHANG, J.-Q., Yu, Y., Shuai, Y. A. O., Gao, M., Shi-Fei, W. U., Wen-Long, W. E. I., Bi, Q., et al. (2022) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(22)60185-7 · Cited by 8 · see citing works
Achyranbidens A–C: three new compounds from Achyranthes bidentata Blume
Thị, N., Anh, B. T. M., Xuan, V. T., Lan, H. T. T., Yến, D. T. H., Tài, B. H., Nhiệm, N. X., & Kiệm, P. V. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2174534 · Cited by 5 · see citing works
“…Hanquet, et al. 2001; Mitaine-Offer, Marouf, Pizza, et al. 2001; Ju et al. 2021; Kiuchi 2022), ecdysteroids (Dat et al. 2012; Zhang et al. 2012; Yang et al. 2017; Wang et al. 2022), flavonoids (Nicolov et al. 1996; Tan et al. 2016), polysaccharides (Fu et al. 2022), and other composition (Dong…”
Yang, Z., Deng, B., Song, R., Gao, C., Sun, Y., Zhu, T., Zhu, L., & Sheng, H. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122048 · Cited by 1 · see citing works
Dobrowolska, E., Motyka, S., Szopa, A., & Ekiert, H. (2022) · Farmacja Polska · doi:10.32383/farmpol/146835 · Cited by 1 · see citing works
Chemoselective Synthesis of 2-Ester and Dioxolane Derivatives of 20-Hydroxyecdysone and Poststerone
Савченко, Р. Г., & Parfenova, L. V. (2025) · Chemistry of Natural Compounds · doi:10.1007/s10600-025-04737-9 · Cited by 1 · see citing works
Zhang, L., Shi, X., Huang, Z., Mao, J., Mei, W., Ding, L., Zhang, L., Xing, R., & Wang, P. (2020) · Figshare · doi:10.6084/m9.figshare.12172101
Zhang, L., Shi, X., Huang, Z., Mao, J., Mei, W., Ding, L., Zhang, L., Xing, R., & Wang, P. (2020) · Figshare · doi:10.6084/m9.figshare.12172089
Zhang, L., Shi, X., Huang, Z., Mao, J., Mei, W., Ding, L., Zhang, L., Xing, R., & Wang, P. (2020) · Figshare · doi:10.6084/m9.figshare.12172077
Zhang, L., Shi, X., Huang, Z., Mao, J. J. J., Mei, W., Ding, L., Zhang, L., Xing, R., & Wang, P. (2020) · Figshare · doi:10.6084/m9.figshare.12172095
Clinical Applications and Efficacy of Achyranthes bidentata in Bone and Joint Disorders
Dong, W., Yu, Y., Xu, L., Hong-qi, Y., Yang, Q., & Liang, H. (2024) · Medicinal Plant Research · doi:10.5376/mpr.2024.14.0005 · Cited by 1 · see citing works
Zhang, L., Shi, X., Huang, Z., Mao, J., Mei, W., Ding, L., Zhang, L., 邢润麟, & Wang, P. (2020) · Figshare · doi:10.6084/m9.figshare.12172083
Park, J., Lee, D. Y., Mariano, E., Choi, Y., Han, D., Kim, J. S., Park, J. W. P. J. W., Namkung, S., Lee, S. Y., Lee, H. W., et al. (2026) · Food Science of Animal Resources · doi:10.1007/s44463-025-00003-2
- Authors
- Yang, L., Jiang, H., Yan, M.-L., Xing, X.-D., Zhang, Y.-Y., Wei, N., Yang, B.-Y., Wang, Q.-H., & Kuang, H.-X.
- Affiliations
- Heilongjiang University of Chinese Medicine (CN)
- Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China
- Hainan Medical University (CN)
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2016-12-29
- Volume
- 31
- Issue
- 9
- Pages
- 1073-1079
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2566716187
- Cited by
- 17
- References
- 25
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2020: 4 · 2019: 1 · 2018: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Heilongjiang Postdoctoral Innovation Foundation (No. LBH-Z10020)
- the Heilongjiang Universityof Chinese Medicine Doctoral Innovation Foundation (No. 2013bs04)
- Innovative Talents Funding of Heilongjiang University of Chinese Medicine (2012RCQ20)
- the Specialized Research Fund for the Doctoral Program of Higher Education ofChina (No. 20132327120003)
- the Natural Science Foundation of Heilongjiang Province (No. H201324)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Keywords
- phytoecdysteroids, Achyranthes bidentata, root constituents, structure elucidation, anti-inflammatory activity, nitric oxide production, lipopolysaccharide-induced inflammation, RAW 264.7 macrophages, natural product isolation
- MeSH terms
- Magnetic Resonance Spectroscopy, Plant Roots, Ecdysteroids, Achyranthes
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