Cited by 69Fungal Biology and ApplicationsPhytochemistry and Biological ActivitiesPhytochemical Studies and Bioactivities

New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus

Sun, Yi, Yasukawa, Ken·2008·Bioorganic & Medicinal Chemistry Letters

Abstract

Bioassay-guided fractionation of the ethyl acetate extract from the sclerotium of Polyporus umbellatus resulted in the isolation of three new ergostane-type ecdysteroids, named polyporoid A (1), B (2), and C (3), together with five known ecdysteroids. The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, (1)H and (13)C NMR, and 2D NMR) analyses. All compounds (1-8) exhibited potent anti-inflammatory activity in the test of TPA-induced inflammation (1 microg/ear) in mice, with ID(50) values in the range of 0.117-0.682 microM/ear.

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Crossref · 10.1016/j.bmcl.2008.04.008

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  • Five new ecdysteroids, (20S,20R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (206), (23R,24R,25R)-23,26-epoxy-3β,14α,20α,22α-tetrahydroxyergost-7-en-6-one (207), polyporoid A (208), polyporoid B (209), and polyporoid C (210), were isolated from Polyporus umbellatus.

    “five new ecdysteroids, (20S,20R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (206), (23R,24R,25R)-23,26-epoxy-3β,14α,20α,22α-tetrahydroxyergost-7-en-6-one (207), polyporoid A (208), polyporoid B (209), and polyporoid C (210) are all isolated from the plant Polyporus umbellatus145,146.”

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Authors
Sun, Y., & Yasukawa, K.
Affiliations
Nihon University (JP)
Corresponding author
Yasukawa, Ken
Venue
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier BV
Published
2008-06
Volume
18
Issue
11
Pages
3417-3420
ISSN
0960-894X (ISSN-L)
OpenAlex
W1992625181
Cited by
69
References
15
Citations by year
2026: 5 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 5 · 2016: 2 · 2015: 6 · 2013: 5 · 2012: 10
FWCI
3.97
Type
journal article
Language
en
Open access
closed
Locations
  • Bioorganic & Medicinal Chemistry Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Nihon University
Topics
  • Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Keywords
Polyporus umbellatus, sclerotia, anti-inflammatory activity, TPA-induced ear edema, fungal natural products, structure elucidation
MeSH terms
Animals, Anti-Inflammatory Agents, Ergosterol, Polyporaceae, Structure-Activity Relationship, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Inhibitory Concentration 50, Combinatorial Chemistry Techniques, Ecdysteroids, Mice

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