New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus
Abstract
Bioassay-guided fractionation of the ethyl acetate extract from the sclerotium of Polyporus umbellatus resulted in the isolation of three new ergostane-type ecdysteroids, named polyporoid A (1), B (2), and C (3), together with five known ecdysteroids. The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, (1)H and (13)C NMR, and 2D NMR) analyses. All compounds (1-8) exhibited potent anti-inflammatory activity in the test of TPA-induced inflammation (1 microg/ear) in mice, with ID(50) values in the range of 0.117-0.682 microM/ear.
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Five new ecdysteroids, (20S,20R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (206), (23R,24R,25R)-23,26-epoxy-3β,14α,20α,22α-tetrahydroxyergost-7-en-6-one (207), polyporoid A (208), polyporoid B (209), and polyporoid C (210), were isolated from Polyporus umbellatus.
“five new ecdysteroids, (20S,20R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (206), (23R,24R,25R)-23,26-epoxy-3β,14α,20α,22α-tetrahydroxyergost-7-en-6-one (207), polyporoid A (208), polyporoid B (209), and polyporoid C (210) are all isolated from the plant Polyporus umbellatus145,146.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [145]
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- Authors
- Sun, Y., & Yasukawa, K.
- Affiliations
- Nihon University (JP)
- Corresponding author
- Yasukawa, Ken
- ORCID
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 18
- Issue
- 11
- Pages
- 3417-3420
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W1992625181
- Cited by
- 69
- References
- 15
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 5 · 2016: 2 · 2015: 6 · 2013: 5 · 2012: 10
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nihon University
- Topics
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- Polyporus umbellatus, sclerotia, anti-inflammatory activity, TPA-induced ear edema, fungal natural products, structure elucidation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Ergosterol, Polyporaceae, Structure-Activity Relationship, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Inhibitory Concentration 50, Combinatorial Chemistry Techniques, Ecdysteroids, Mice
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