The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Natural products for human health: an historical overview of the drug discovery approaches
Abstract
Natural products (NPs) are secondary metabolites produced and used by organisms for defending or adapting purposes. These molecules were naturally selected during thousands of years to improve the specificity and cover a very wide range of functions, depending on the origin, the habitat and the specific activity carried out in the organism of origin. Due to these intrinsic features, NPs have been used as healing agents since thousands of years and still today continue to be the most important source of new potential therapeutic preparations.The purpose of this review is to provide information about the historical evolution of the NPs investigation methods, focusing attention on the relative benefit/problems emerged after the improvement of the scientific investigations about them, especially over the last two centuries. Taken together, the reported information lead to the central role of NPs in the future of drug development for human needs.
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1 retracted
RETRACTED: Marine actinobacteria as a drug treasure house
Hassan, S. S. U., & Shaikh, A. L. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.086 · Cited by 95
RetractedNatural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
Natural products as sources of new drugs over the 30 years from 1981 to 2010
Newman, D. J., & Cragg, G. M. (2012) · Journal of Natural Products · doi:10.1021/np200906s · Cited by 4,687
Can the pharmaceutical industry reduce attrition rates?
Kola, I., & Landis, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1470 · Cited by 4,167
Natural products as sources of new drugs over the period 1981–2002
Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082
Natural products: A continuing source of novel drug leads
Cragg, G. M., & Newman, D. J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.02.008 · Cited by 2,906
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Atanasov, A. G., Waltenberger, B., Pferschy-Wenzig, E.-M., Linder, T., Wawrosch, C., Uhrin, P., Temml, V., Wang, L., Schwaiger, S., Heiss, E. H., et al. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.08.001 · Cited by 2,904
The evolving role of natural products in drug discovery
Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,572
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
Li, J. W.-H., & Vederas, J. C. (2009) · Science · doi:10.1126/science.1168243 · Cited by 2,052
The value of plants used in traditional medicine for drug discovery.
Fabricant, D. S., & Farnsworth, N. R. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s169 · Cited by 2,038
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“Natural compounds from plant extracts are often used as source of food preservatives [4,5] and pharmaceutical agents [6,7] in the food and clinical sector, mainly with antimicrobial and antioxidant purposes.”
BackgroundGinkgetin: A natural biflavone with versatile pharmacological activities
Adnan, M., Rasul, A., Hussain, G., Shah, M. A., Zahoor, M. K., Anwar, H., Sarfraz, I., Riaz, A., Manzoor, M., Adem, Ş., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111642 · Cited by 102
Journey of the Probiotic Bacteria: Survival of the Fittest
Mendonça, A. A., Pinto-Neto, W. D. P., da Paixão, G. A., Santos, D. D. S., De Morais, M. A., & De Souza, R. B. (2022) · Microorganisms · doi:10.3390/microorganisms11010095 · Cited by 82
Metadata
- Authors
- Bernardini, S., Tiezzi, A., Laghezza Masci, V., & Ovidi, E.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2017-07-27
- Volume
- 32
- Issue
- 16
- Pages
- 1926-1950
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2740619240
- Cited by
- 355
- References
- 130
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bernardini, S., Tiezzi, A., Laghezza Masci, V., & Ovidi, E. (2018). Natural products for human health: an historical overview of the drug discovery approaches. Natural Product Research. https://doi.org/10.1080/14786419.2017.1356838
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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