The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Natural products: A continuing source of novel drug leads
Open accessAbstract
1. Background Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug discovery from microbial sources occurred and diving techniques in the 1970s opened the seas. Combinatorial chemistry (late 1980s), shifted the focus of drug discovery efforts from Nature to the laboratory bench. 2. Scope of Review This review traces natural products drug discovery, outlining important drugs from natural sources that revolutionized treatment of serious diseases. It is clear Nature will continue to be a major source of new structural leads, and effective drug development depends on multidisciplinary collaborations. 3. Major Conclusions The explosion of genetic information led not only to novel screens, but the genetic techniques permitted the implementation of combinatorial biosynthetic technology and genome mining. The knowledge gained has allowed unknown molecules to be identified. These novel bioactive structures can be optimized by using combinatorial chemistry generating new drug candidates for many diseases. 4 General Significance: The advent of genetic techniques that permitted the isolation / expression of biosynthetic cassettes from microbes may well be the new frontier for natural products lead discovery. It is now apparent that biodiversity may be much greater in those organisms. The numbers of potential species involved in the microbial world are many orders of magnitude greater than those of plants and multi-celled animals. Coupling these numbers to the number of currently unexpressed biosynthetic clusters now identified (>10 per species) the potential of microbial diversity remains essentially untapped.
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Citations
Cites
Natural products as sources of new drugs over the last 25 years
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Self-citationNatural products as sources of new drugs over the 30 years from 1981 to 2010
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Self-citationEnvironmental genome shotgun sequencing of the sargasso sea
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Drugs for bad bugs: confronting the challenges of antibacterial discovery
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Impact of high-throughput screening in biomedical research
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Isolation of Artemisinin (Qinghaosu) from Artemisia annua Growing in the United States
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BackgroundInfluentialConfronting the challenges of natural product-based antifungal discovery
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Cited by
Natural products as sources of new drugs from 1981 to 2014
Newman, D. J., & Cragg, G. M. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b01055 · Cited by 5,858
Self-citationTechniques for extraction and isolation of natural products: A comprehensive review
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SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping
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Metadata
- Authors
- Cragg, G. M., & Newman, D. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 1830
- Issue
- 6
- Pages
- 3670-3695
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W1965694039
- Cited by
- 2,906
- References
- 9
- FWCI
- 121.84
- Type
- journal article
- Language
- en
- Open access
- green
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