Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide
Open accessAbstract
In the mid 1990s a number of research groups recognized that mitochondrial oxygen consumption could be reversibly inhibited by nitric oxide at the level of the enzyme cytochrome c oxidase. The inhibition was apparently competitive with respect to the oxygen concentration. This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase.
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Based on the amount of NO required to inhibit cytochrome c oxidase, there is likely a few hundred nanomolar cytochrome c in cells.
“Based on the amount of NO required to inhibit cytochrome c oxidase, there is likely a few hundred nanomolar cytochrome c in cells [80].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [80]
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., Cooper, C. E., & Knowles, R. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570593 · Cited by 4,106 · see citing works
Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241 · see citing works
Ignarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,164 · see citing works
Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works
Does nitric oxide modulate mitochondrial energy generation and apoptosis?
Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works
Thomas, D. D., Liu, X., Kantrow, S. P., & Lancaster, J. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.355 · Cited by 760 · see citing works
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602 · see citing works
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
Brown, G. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00763-y · Cited by 540 · see citing works
Nitric oxide and iron proteins
Cooper, C. E. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00021-3 · Cited by 510 · see citing works
Bolaños, J. P., Heales, S., Land, J. M., & Clark, J. B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64051965.x · Cited by 492 · see citing works
Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes
Bolaños, J. P., Peuchen, S., Heales, S., Land, J. M., & Clark, J. B. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030910.x · Cited by 413 · see citing works
Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension
Schweizer, M., & Richter, C. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2441 · Cited by 331 · see citing works
Control of mitochondrial and cellular respiration by oxygen
Gnaiger, E., Steinlechner-Maran, R., Méndez, G., Eberl, T., & Margreiter, R. (1995) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02111656 · Cited by 316 · see citing works
Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00901-2 · Cited by 298 · see citing works
On the mechanism by which vascular endothelial cells regulate their oxygen consumption
Clementi, E., Brown, G. C., Foxwell, N., & Moncada, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1559 · Cited by 296 · see citing works
Reactions of nitric oxide with cytochrome c oxidase
Brudvig, G. W., Stevens, T. H., & Chan, S. I. (1980) · Biochemistry · doi:10.1021/bi00564a020 · Cited by 237 · see citing works
Ignarro, L. J. (1990) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1990.tb00772.x · Cited by 229 · see citing works
Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?
Cooper, C. E. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)02035-7 · Cited by 223 · see citing works
Shiva, S., Brookes, P. S., Patel, R. P., Anderson, P. G., & Darley-Usmar, V. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131128898 · Cited by 212 · see citing works
Torres, J., Darley-Usmar, V. M., & Wilson, M. T. (1995) · Biochemical Journal · doi:10.1042/bj3120169 · Cited by 206 · see citing works
Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration
Brown, G. C., Bolaños, J. P., Heales, S., & Clark, J. B. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11703-y · Cited by 205 · see citing works
Gegg, M. E., Beltrán, B., Salas-Pino, S., Bolaños, J. P., Clark, J. B., Moncada, S., & Heales, S. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01821.x · Cited by 168 · see citing works
Nitric Oxide and Cytochrome c Oxidase: Mechanisms of Inhibition and NO Degradation
Sarti, P., Giuffrè, A., Forte, E., Mastronicola, D., Barone, M. C., & Brunori, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3117 · Cited by 168 · see citing works
Characterization and function of mitochondrial nitric-oxide synthase
Giulivi, C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01298-4 · Cited by 144 · see citing works
On the Mechanism of Inhibition of Cytochrome c Oxidase by Nitric Oxide
Giuffrè, A., Sarti, P., D’Itri, E., Buse, G., Soulimane, T., & Brunori, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33404 · Cited by 144 · see citing works
Brookes, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00805-x · Cited by 137 · see citing works
Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase
Sharpe, M. A., & Cooper, C. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30961 · Cited by 133 · see citing works
Self-citationKinetics of the inhibition of mitochondrial respiration by NO
Koivisto, A., Matthias, A., Bronnikov, G. E., & Nedergaard, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01258-1 · Cited by 126 · see citing works
Studies of the primary oxygen intermediate in the reaction of fully reduced cytochrome oxidase.
Blackmore, R. S., Greenwood, C., & Gibson, Q. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54989-9 · Cited by 125 · see citing works
Bellamy, T. C., Griffiths, C., & Garthwaite, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205936200 · Cited by 124 · see citing works
Control of Mitochondrial Respiration by NO., Effects of Low Oxygen and Respiratory State
Brookes, P. S., Kraus, D. W., Shiva, S., Doeller, J. E., Barone, M.-C., Patel, R. P., Lancaster, J. R., & Darley-Usmar, V. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211784200 · Cited by 118 · see citing works
Cooper, C. E., Torres, J., Sharpe, M. A., & Wilson, M. T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01009-0 · Cited by 108 · see citing works
Dissociation of Nitric Oxide from Soluble Guanylate Cyclase
Kharitonov, V. G., Russwurm, M., Magde, D., Sharma, V. S., & Koesling, D. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7470 · Cited by 101 · see citing works
Kinetic trapping of oxygen in cell respiration
Verkhovsky, M. I., Morgan, J. E., Puustinen, A., & Wikström, M. K. F. (1996) · Nature · doi:10.1038/380268a0 · Cited by 98 · see citing works
REACTIONS OF CYTOCHROME OXIDASE
Wainio, W. W. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71011-9 · Cited by 81 · see citing works
Cooper, C. E., Davies, N. A., Psychoulis, M., Canevari, L., Bates, T. E., Dobbie, M. S., Casley, C. S., & Sharpe, M. A. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.08.003 · Cited by 70 · see citing works
Cooper, C. E., Delpy, D. T., & Nemoto, E. M. (1998) · Biochemical Journal · doi:10.1042/bj3320627 · Cited by 65 · see citing works
Quaresima, V., Springett, R., Cope, M., Wyatt, J. S., Delpy, D. T., Ferrari, M., & Cooper, C. E. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00129-7 · Cited by 53 · see citing works
Letellier, T., Bédes, F., Malgat, M., Korzeniewski, B., Jouaville, L. S., & Morkūnienė, R. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006875517267 · Cited by 52 · see citing works
Measurement of Cytochrome Oxidase Redox State by Near Infrared Spectroscopy
Cooper, C. E., Cope, M., Quaresima, V., Ferrari, M., Nemoto, E. M., Springett, R., Matcher, S. J., Amess, P., Penrice, J., Tyszczuk, L., et al. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-0056-2_7 · Cited by 48 · see citing works
EPR studies of the photodissociation reactions of cytochrome c oxidase-nitric oxide complexes
Boelens, R., Rademaker, H., Pel, R., & Wever, R. (1982) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(82)90258-4 · Cited by 47 · see citing works
Edmunds, N. J., Moncada, S., & Marshall, J. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023663 · Cited by 43 · see citing works
Nitric Oxide Reacts with the Single-electron Reduced Active Site of Cytochrome c Oxidase
Giuffrè, A., Barone, M. C., Brunori, M., D’Itri, E., Ludwig, B., Malatesta, F., Müller, H.-W., & Sarti, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201514200 · Cited by 32 · see citing works
Nitric oxide synthase does not contribute to cerebral autoregulatory phenomenon in anesthetized dogs
Saito, S., Wilson, D. A., Hanley, D. F., & Traystman, R. J. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90091-4 · Cited by 26 · see citing works
Visscher, G. D., Springett, R., Delpy, D. T., Reempts, J. V., Borgers, M. J., & van Rossem, K. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200205000-00002 · Cited by 24 · see citing works
Petersen, L. C., Degn, H., & Nicholls, P. J. (1977) · Canadian Journal of Biochemistry · doi:10.1139/o77-102 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Hall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451 · see citing works
“…into the slice, c is the concentration of O2, D is its diffusion coefficient in brain at 37°C (1.54 10 9 m 2/s) (Ganfield et al., 1970), Km 1 M is the EC50 for O2 activating oxidative phosphorylation (Cooper, 2003), and Vmax is the maximum rate of oxidative phosphorylation at saturating [O2].”
BackgroundInfluentialEndothelial Mitochondria: Contributing to Vascular Function and Disease
Davidson, S. M., & Duchen, M. R. (2007) · Circulation Research · doi:10.1161/01.res.0000261970.18328.1d · Cited by 381 · see citing works
Dranka, B. P., Hill, B. G., & Darley-Usmar, V. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.015 · Cited by 329 · see citing works
“An important physiologically relevant modulator of mitochondrial respiration is NO [41].”
BackgroundMitochondrial respiratory chain and free radical generation in stroke
Moro, M. Á., Almeida, Á., Bolaños, J. P., & Lizasoaín, I. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.07.010 · Cited by 240 · see citing works
Nitrite-driven anaerobic ATP synthesis in barley and rice root mitochondria
Stoimenova, M., Igamberdiev, A. U., Gupta, K. J., & Hill, R. D. (2007) · Planta · doi:10.1007/s00425-007-0496-0 · Cited by 238 · see citing works
“…but the saturating oxygen concentrations required may be higher than expected if NO is present due to the sensitivity of the oxidase to NO at both the heme and copper sites of the complex (Mason et al. 2006) occurring at nanomolar concentrations of NO (Brown and Cooper 1994; Cooper 2003).”
BackgroundMason, M. G., Nicholls, P., Wilson, M. T., & Cooper, C. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506562103 · Cited by 233 · see citing works
Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism
Somasundaram, V., Basudhar, D., Bharadwaj, G., No, J. H., Ridnour, L. A., Cheng, R. Y. S., Fujita, M., Thomas, D. D., Anderson, S. K., McVicar, D. W., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7527 · Cited by 215 · see citing works
“Sustained high NO level would lead to chronic mitochondrial depolarization through direct chemical interaction of NO with the Fe–S clusters of the respiratory complex proteins (16, 31, 136).”
BackgroundShaw, K., Bell, L., Boyd, K., Grijseels, D. M., Clarke, D., Bonnar, O., Crombag, H. S., & Hall, C. N. (2021) · Nature Communications · doi:10.1038/s41467-021-23508-y · Cited by 184 · see citing works
Mechanisms of nitrite bioactivation
Kim-Shapiro, D. B., & Gladwin, M. T. (2014) · Nitric Oxide · doi:10.1016/j.niox.2013.11.002 · Cited by 157 · see citing works
“Based on the amount of NO required to inhibit cytochrome c oxidase, there is likely a few hundred nanomolar cytochrome c in cells [80].”
BackgroundThe Haemoglobin/Nitric Oxide Cycle: Involvement in Flooding Stress and Effects on Hormone Signalling
Igamberdiev, A. U., Baron, K. N., Manac'h, N., STOIMENOVA, M., & Hill, R. D. (2005) · Annals of Botany · doi:10.1093/aob/mci210 · Cited by 155 · see citing works
“The physiological situation is more complex, however, as cytochrome c oxidase is capable of converting NO to nitrite (Pearce et al., 2002; Cooper, 2003).”
BackgroundBolaños, J. P., Moro, M. Á., Lizasoaín, I., & Almeida, Á. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.009 · Cited by 119 · see citing works
McDonald, A. E., & Vanlerberghe, G. C. (2004) · IUBMB Life · doi:10.1080/1521-6540400000876 · Cited by 118 · see citing works
Anoxic nitric oxide cycling in plants: participating reactions and possible mechanisms
Igamberdiev, A. U., Bykova, N. V., Shah, J. K., & Hill, R. D. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01314.x · Cited by 110 · see citing works
Cancer cell metabolism and the modulating effects of nitric oxide
Chang, C.-F., Diers, A. R., & Hogg, N. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.012 · Cited by 101 · see citing works
Zhang, J., Jin, B., Li, L., Block, E. R., & Patel, J. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00325.2004 · Cited by 102 · see citing works
“This short-term exposure to physiological concentrations of NO rapidly inhibits complex IV in a reversible manner that is competitive with oxygen (15, 18).”
BackgroundNitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression
Basudhar, D., Somasundaram, V., de Oliveira, G. A., Kesarwala, A., Heinecke, J. L., Cheng, R. Y. S., Glynn, S., Ambs, S., Wink, D., & Ridnour, L. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6813 · Cited by 80 · see citing works
“NO regulation of O2 consumption by direct binding and reversible inhibition at the ferrous heme site of complex IV has been well documented (20).”
BackgroundAucouturier, J., Boissière, J., Pawlak-Chaouch, M., Cuvelier, G., & Gamelin, F.-X. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.05.004 · Cited by 85 · see citing works
Mitochondrial dysfunction in human pathologies
Monsalve, M. (2006) · Frontiers in bioscience · doi:10.2741/2132 · Cited by 75 · see citing works
“Cytochrome oxidase or complex IV is the terminal enzyme of the mitochondrial respiratory chain that is responsible for over 95% of cellular O 2 consumption in mammals and that is inhibitable by NO in a direct interaction with the enzyme (153, 154).”
BackgroundArmstrong, W., Beckett, P. M., Colmer, T. D., Setter, T. L., & Greenway, H. (2019) · Journal of Plant Physiology · doi:10.1016/j.jplph.2019.04.010 · Cited by 66 · see citing works
Hypothalamic Nitric Oxide in Hypoglycemia Detection and Counterregulation: A Two-Edged Sword
Fioramonti, X., Song, Z., Vazirani, R. P., Beuve, A. V., & Routh, V. H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3331 · Cited by 56 · see citing works
“A consequence of mitochondrial respiration inhibition is the production of the superoxide anion O2 (18) (Fig.”
Assessing the physiological concentration and targets of nitric oxide in brain tissue
Hall, C. N., & Attwell, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.154724 · Cited by 52 · see citing works
“…the slice, DO2 is the diffusion constant for O2 (9.54 × 10−4 cm2 min−1; Ganfield et al. 1970), K O2 is the K m for O2 consumption by CcO in tissue (1 μM; Cooper, 2003) and VO2 is the maximum rate of O2 consumption per unit volume in the slice: ∂O2 ∂t = DO2 ∂2O2 ∂x2 − VO2 O2 K O2 + O2 (1) VO2 was…”
BackgroundInfluentialNon-signalling energy use in the developing rat brain
Engl, E., Jolivet, R., Hall, C. N., & Attwell, D. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16648710 · Cited by 47 · see citing works
Nitric Oxide and Cancer: When to Give and When to Take Away?
Miranda, K. M., Ridnour, L. A., McGinity, C. L., Bhattacharyya, D., & Wink, D. A. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c02434 · Cited by 48 · see citing works
Quirk, B. J., & Whelan, H. T. (2020) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2020.4905 · Cited by 47 · see citing works
Modulation of Astroglial Energy Metabolism by Nitric Oxide
Bolaños, J. P., & Almeida, Á. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.955 · Cited by 43 · see citing works
“Since semiquinone is an effective source of O 2•”
Hyperoxia results in increased aerobic metabolism following acute brain injury
Ghosh, A., Highton, D., Kolyva, C., Tachtsidis, I., Elwell, C. E., & Smith, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16679171 · Cited by 36 · see citing works
“It is interesting to note that nitric oxide is known to increase the Km of CCO, and the proposed mechanism of action for normobaric and hyperbaric hyperoxia is the reversal of this nitric oxide effect thereby reducing the threshold at which oxygen becomes a rate limiting step in oxidative metabolism.(24) Thus, our res…”
BackgroundMancini, A., Tantucci, M., Mazzocchetti, P., de Iure, A., Durante, V., Macchioni, L., Giampà, C., Alvino, A., Gaetani, L., Costa, C., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.002 · Cited by 36 · see citing works
A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase
Cooper, C. E., Mason, M. G., & Nicholls, P. J. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.021 · Cited by 36 · see citing works
Differential regulation of metabolism by nitric oxide and<i>S</i>-nitrosothiols in endothelial cells
Diers, A. R., Broniowska, K. A., Darley-Usmar, V. M., & Hogg, N. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00210.2011 · Cited by 26 · see citing works
Fioramonti, X., Deák, Á., Deshpande, S., Carneiro, L., Zhou, C., Sayed, N., Orban, B., Berlin, J. R., Pénicaud, L., Leloup, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068709 · Cited by 24 · see citing works
“In support of this, NO inhibits mitochondrial cytochrome c and blocks mitochondrial respiration which consequently increases superoxide anion O2 N2 production [36].”
BackgroundCO Sniffing through Heme‐based Sensor Proteins
Ascenzi, P., Bocedi, A., Leoni, L., Visca, P., Zennaro, E., Milani, M., & Bolognesi, M. (2004) · IUBMB Life · doi:10.1080/10258140412331286937 · Cited by 17 · see citing works
Shaw, K., Bell, L., Boyd, K., Grijseels, D. M., Clarke, D., Bonnar, O., Crombag, H. S., & Hall, C. N. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/835728 · Cited by 10 · see citing works
5.2 Nitric Oxide in Regulation of Mitochondrial Function, Respiration, and Glycolysis
Bolaños, J. P., & Almeida, Á. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_18 · Cited by 8 · see citing works
Wang, E., Wang, M., & Gao, M. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70002 · Cited by 7 · see citing works
“41,42 In competitive inhibition, inhibitors compete with substrates for binding sites, preventing substrate binding.”
BackgroundHeme Protein Metabolism of NO and Nitrite
Kim‐Shapiro, D. B., & Gladwin, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00006-5 · Cited by 5 · see citing works
Purification of Class 1 Plant Hemoglobins and Examination of Their Functional Properties
Igamberdiev, A. U., & Hill, R. D. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)36021-2 · Cited by 2 · see citing works
NO in Cancer—Carcinogenesis, Metastasis, and Therapy
Somasundaram, V., Basudhar, D., Greer, M., Cheng, R. Y. S., Ridnour, L. A., & Wink, D. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00028-4 · Cited by 2 · see citing works
Alonso, D. P., Berg, M., Boyer, F., Fomin-Thunemann, N., Quintard, M., Davit, Y., & Lorthois, S. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011973 · Cited by 1 · see citing works
Chocobar-Ponce, S., Prado, C., Gonzalez, R. E., Rosa, M. D., & Prado, F. E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8591-9_12 · Cited by 1 · see citing works
Bonnar, O., Shaw, K., Grijseels, D. M., Clarke, D., Bell, L., Anderle, S., King, S. L., & Hall, C. N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.26.445731 · Cited by 1 · see citing works
“Menten kinetics with a Km of 1 μM, from the EC50 for oxygen at cytochrome c oxidase (Cooper, 2003), 732 and a Vmax of 2 mM/min (Gould et al.”
Nitric Oxide Regulation in Redox Signaling
Vitturi, D. A., Krzywanski, D. M., Postlethwait, E. M., & Patel, R. P. (2009) · Wiley eBooks · doi:10.1002/9783527627585.ch12
Nouhi, M. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Cellular Mechanisms of Sleep Homeostasis : Studies on Brain Energy Metabolism and Aging
Wigren, H. (2009) · Työväentutkimus Vuosikirja
Harrois, A., & Duranteau, J. (2007) · Springer eBooks · doi:10.1007/978-2-287-71152-7_7
- Authors
- Cooper, C.
- Affiliations
- University of Essex (GB)
- Corresponding author
- Cooper, Chris
- ORCID
- Cooper, Chris
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2003-01
- Volume
- 55
- Issue
- 10-11
- Pages
- 591-597
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W1977701096
- Cited by
- 46
- References
- 48
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Keywords
- nitric oxide, cytochrome c oxidase, competitive inhibition, reversible inhibition, mitochondrial oxygen consumption, enzyme inhibition, mitochondrial respiration
- MeSH terms
- Animals, Electron Transport Complex IV, Dose-Response Relationship, Drug, Hemoglobins, Humans, Kinetics, Mitochondria, Models, Chemical, Nitric Oxide, Oxygen, Oxygen Consumption
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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