The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The Central Role of Perilipin A in Lipid Metabolism and Adipocyte Lipolysis
Open accessAbstract
The related disorders of obesity and diabetes are increasing to epidemic proportions. The role of neutral lipid storage and hydrolysis, and hence the adipocyte, is central to understanding this phenomenon. The adipocyte holds the major source of stored energy in the body in the form of triacylglycerols (TAG). It has been known for over 35 years that the breakdown of TAG and release of free (unesterified) fatty acids and glycerol from fat tissue can be regulated by a cAMP‐mediated process. However, beyond the initial signaling cascade, the mechanistic details of this lipolytic reaction have remained unclear. Work in recent years has revealed that both hormone‐sensitive lipase (HSL), generally thought to be the rate‐limiting enzyme, and perilipin, a lipid droplet surface protein, are required for optimal lipid storage and fatty acid release. There are multiple perilipin proteins encoded by mRNA splice variants of a single perilipin gene. The perilipin proteins are polyphosphorylated by protein kinase A and phosphorylation is necessary for translocation of HSL to the lipid droplet and enhanced lipolysis. Hence, the surface of the lipid storage droplet has emerged as a central site of regulation of lipolysis. This review will focus on adipocyte lipolysis with emphasis on hormone signal transduction, lipolytic enzymes, the lipid storage droplet, and fatty acid release from the adipocyte. IUBMB Life, 56: 379‐385, 2004
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Cites
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038
Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790
Life without white fat: a transgenic mouse
Moitra, J., Mason, M. M., Olive, M., Krylov, D., Gavrilova, O., Marcus-Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 782
Tansey, J. T., Sztalryd, C., Gruia-Gray, J., Roush, D. L., Zee, J. V., Gavrilova, O., Reitman, M. L., Deng, C.-X., Li, C., Kimmel, A. R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101042998 · Cited by 734
Self-citationBrasaemle, D. L., Barber, T., Wolins, N. E., Serrero, G., Blanchette-Mackie, E. J., & Londos, C. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34939-7 · Cited by 644
Self-citationAbsence of perilipin results in leanness and reverses obesity in Leprdb/db mice
Martinez-Botas, J., Anderson, J. B., Tessier, D., Lapillonne, A., Chang, B. H.-J., Quast, M. J., Gorenstein, D., Chen, K.-H., & Chan, L. (2000) · Nature Genetics · doi:10.1038/82630 · Cited by 581
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
Holm, C., Østerlund, T., Laurell, H., & Contreras, J. A. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.365 · Cited by 564
Sztalryd, C., Xu, G., Dorward, H., Tansey, J. T., Contreras, J. A., Kimmel, A. R., & Londos, C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210169 · Cited by 535
Self-citationNatriuretic peptides: a new lipolytic pathway in human adipocytes
Sengenès, C., Berlan, M., de Glisezinski, I., Lafontan, M., & Galitzky, J. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1345 · Cited by 532
Anthonsen, M. W., Rönnstrand, L., Wernstedt, C., Degerman, E., & Holm, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.215 · Cited by 468
Cited by
Regulation of Lipolysis in Adipocytes
Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021
Gene networks driving bovine milk fat synthesis during the lactation cycle
Bionaz, M., & Loor, J. J. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-366 · Cited by 785
Regulatory role for the arginine–nitric oxide pathway in metabolism of energy substrates
Jobgen, W. S., Fried, S. K., Fu, W. J., Meininger, C. J., & Wu, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.12.001 · Cited by 710
Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800031-jlr200 · Cited by 576
Koerner, A., Kratzsch, J., & Kiess, W. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.008 · Cited by 471
Metadata
- Authors
- Tansey, J., Sztalryd, C., Hlavin, E., Kimmel, A., & Londos, C.
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 56
- Issue
- 7
- Pages
- 379-385
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W1976879072
- Cited by
- 275
- References
- 37
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- green
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