The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
Abstract
Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a pivotal role in lipid metabolism, overall energy homeostasis, and, presumably, cellular events involving fatty acid signaling. Detailed knowledge about its structure and regulation may provide information regarding the pathogenesis of such human diseases as obesity and diabetes and may generate concepts for new treatments of these diseases. The current review summarizes the recent advances with regard to hormone-sensitive lipase structure and molecular mechanisms involved in regulating its activity and lipolysis in general. A summary of the current knowledge regarding regulation of expression, potential involvement in lipid disorders, and role in tissues other than adipose tissue is also provided.
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Cited by
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Regulation of Lipolysis in Adipocytes
Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021
The biophysics and cell biology of lipid droplets
Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3699 · Cited by 986
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Tansey, J. T., Sztalryd, C., Gruia-Gray, J., Roush, D. L., Zee, J. V., Gavrilova, O., Reitman, M. L., Deng, C.-X., Li, C., Kimmel, A. R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101042998 · Cited by 734
Metadata
- Authors
- Holm, C., Østerlund, T., Laurell, H., & Contreras, J. A.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2000-07
- Volume
- 20
- Issue
- 1
- Pages
- 365-393
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2165286872
- Cited by
- 564
- References
- 9
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holm, C., Østerlund, T., Laurell, H., & Contreras, J. A. (2000). Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.20.1.365
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
