The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Life without white fat: a transgenic mouse
Open accessAbstract
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2 enhancer/promoter. This protein prevents the DNA binding of B-ZIP transcription factors of both the C/EBP and Jun families. The transgenic mice (named A-ZIP/F-1) have no white adipose tissue and dramatically reduced amounts of brown adipose tissue, which is inactive. They are initially growth delayed, but by week 12, surpass their littermates in weight. The mice eat, drink, and urinate copiously, have decreased fecundity, premature death, and frequently die after anesthesia. The physiological consequences of having no white fat tissue are profound. The liver is engorged with lipid, and the internal organs are enlarged. The mice are diabetic, with reduced leptin (20-fold) and elevated serum glucose (3-fold), insulin (50- to 400-fold), free fatty acids (2-fold), and triglycerides (3- to 5-fold). The A-ZIP/F-1 phenotype suggests a mouse model for the human disease lipoatrophic diabetes (Seip-Berardinelli syndrome), indicating that the lack of fat can cause diabetes. The myriad of consequences of having no fat throughout development can be addressed with this model.
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Cites
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“Lipodystrophic diabetes was recently recognized as a complication of protease inhibitor treatment of HIV infection (Carr et al. 1998).”
BackgroundImpaired Energy Homeostasis in C/EBPα Knockout Mice
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Self-citation
Cited by
Brown Adipose Tissue: Function and Physiological Significance
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Obesity and the regulation of energy balance
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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
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Leptin Inhibits Bone Formation through a Hypothalamic Relay
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Self-citationAdipose Tissue as an Endocrine Organ
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Metadata
- Authors
- Moitra, J., Mason, M. M., Olive, M., Krylov, D., Gavrilova, O., Marcus-Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., Reitman, M. L., & Vinson, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-10-15
- Volume
- 12
- Issue
- 20
- Pages
- 3168-3181
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2163125007
- Cited by
- 782
- References
- 14
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Moitra, J., Mason, M. M., Olive, M., Krylov, D., Gavrilova, O., Marcus-Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., Reitman, M. L., & Vinson, C. (1998). Life without white fat: a transgenic mouse. Genes & Development. https://doi.org/10.1101/gad.12.20.3168
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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