Cited by 193Per- and polyfluoroalkyl substances researchFluorine in Organic ChemistryPeroxisome Proliferator-Activated Receptors

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Perfluorooctane Sulfonate (PFOS) Induces Reactive Oxygen Species (ROS) Production in Human Microvascular Endothelial Cells: Role in Endothelial Permeability

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Qian, Yong, Ducatman, Alan, Ward, Rebecca, Leonard, Steve, Bukowski, Valerie, Lan Guo, Nancy, Shi, Xianglin, Vallyathan, Val, Castranova, Vincent·2010·Journal of Toxicology and Environmental Health, Part A

DOI 10.1080/15287391003689317PMC PMC3107001

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Abstract

Perfluorooctane sulfonate (PFOS) is a member of the perfluoroalkyl acids (PFAA) containing an eight-carbon backbone. PFOS is a man-made chemical with carbon-fluorine bonds that are among the strongest in organic chemistry, and PFOS is widely used in industry. Human occupational and environmental exposure to PFOS occurs globally. PFOS is non-biodegradable and is persistent in the human body and environment. In this study, data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations. Morphologically, it was found that exposure to PFOS induced actin filament remodeling and endothelial permeability changes in HMVEC. Furthermore, data demonstrated that the production of ROS plays a regulatory role in PFOS-induced actin filament remodeling and the increase in endothelial permeability. Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level.

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Authors: Qian, Y., Ducatman, A., Ward, R., Leonard, S., Bukowski, V., Lan Guo, N., Shi, X., Vallyathan, V., & Castranova, V.
Affiliations: National Institute for Occupational Safety and Health (US)
West Virginia University (US)
University of Kentucky (US)
Corresponding author: Qian, Yong
ORCID: Qian, Yong
Ducatman, Alan
Ward, Rebecca
Shi, Xianglin
Venue: Journal of Toxicology and Environmental Health, Part A
Publisher: Informa UK Limited
Published: 2010-04-14
Volume: 73
Issue: 12
Pages: 819-836
ISSN: 0098-4108 (ISSN-L)
1528-7394
1087-2620
DOI: 10.1080/15287391003689317
PMC: PMC3107001
OpenAlex: W2089669600
Cited by: 191
References: 69
Citations by year: 2026: 20 · 2025: 19 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 14 · 2014: 6 · 2013: 5 · 2012: 9
FWCI: 6.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Toxicology and Environmental Health (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. National Library of Medicine (R01LM009500)
National Center for Research Resources (P20 RR16440, P20RR016440)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: PFOS, perfluoroalkyl acids, reactive oxygen species, endothelial permeability, human microvascular endothelial cells, actin filament remodeling, endothelial barrier dysfunction, PFOS toxicity, environmental exposure
MeSH terms: Animals, Capillary Permeability, Cell Line, Cell Membrane Permeability, Electron Spin Resonance Spectroscopy, Endothelium, Vascular, Environmental Pollutants, Fluorocarbons, Humans, Macrophages, Actin Cytoskeleton, Regeneration, Electric Impedance, Reactive Oxygen Species, Alkanesulfonic Acids, Microscopy, Confocal, Mice, Microvessels

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Perfluorooctane Sulfonate (PFOS) Induces Reactive Oxygen Species (ROS) Production in Human Microvascular Endothelial Cells: Role in Endothelial Permeability

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