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Perfluorooctane Sulfonate (PFOS) Induces Reactive Oxygen Species (ROS) Production in Human Microvascular Endothelial Cells: Role in Endothelial Permeability
Open accessAbstract
Perfluorooctane sulfonate (PFOS) is a member of the perfluoroalkyl acids (PFAA) containing an eight-carbon backbone. PFOS is a man-made chemical with carbon-fluorine bonds that are among the strongest in organic chemistry, and PFOS is widely used in industry. Human occupational and environmental exposure to PFOS occurs globally. PFOS is non-biodegradable and is persistent in the human body and environment. In this study, data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations. Morphologically, it was found that exposure to PFOS induced actin filament remodeling and endothelial permeability changes in HMVEC. Furthermore, data demonstrated that the production of ROS plays a regulatory role in PFOS-induced actin filament remodeling and the increase in endothelial permeability. Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level.
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“Another mechanism by which PFAS disrupt the endothelial barrier of the BBB is through generation of reactive oxygen species (ROS), that are ultimately able to induce remodeling of actin filaments (Qian et al., 2010).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Qian et al., 2010
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“in vivo and in vitro experiments have demonstrated that PFAS exposure can lead to severe inflammation in organs, including the liver, kidneys, and nervous system”
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Metadata
- Authors
- Qian, Y., Ducatman, A., Ward, R., Leonard, S., Bukowski, V., Lan Guo, N., Shi, X., Vallyathan, V., & Castranova, V.
- Affiliations
- National Institute for Occupational Safety and Health (US)
- West Virginia University (US)
- University of Kentucky (US)
- Corresponding author
- Qian, Yong
- Venue
- Journal of Toxicology and Environmental Health, Part A
- Publisher
- Informa UK Limited
- Published
- 2010-04-14
- Volume
- 73
- Issue
- 12
- Pages
- 819-836
- ISSN
- 0098-4108 (ISSN-L)
- 1528-7394
- 1087-2620
- PMC
- PMC3107001
- OpenAlex
- W2089669600
- Cited by
- 191
- References
- 69
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 14 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Toxicology and Environmental Health (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. National Library of Medicine (R01LM009500)
- National Center for Research Resources (P20 RR16440, P20RR016440)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- PFOS, perfluoroalkyl acids, reactive oxygen species, endothelial permeability, human microvascular endothelial cells, actin filament remodeling, endothelial barrier dysfunction, PFOS toxicity, environmental exposure
- MeSH terms
- Animals, Capillary Permeability, Cell Line, Cell Membrane Permeability, Electron Spin Resonance Spectroscopy, Endothelium, Vascular, Environmental Pollutants, Fluorocarbons, Humans, Macrophages, Actin Cytoskeleton, Regeneration, Electric Impedance, Reactive Oxygen Species, Alkanesulfonic Acids, Microscopy, Confocal, Mice, Microvessels
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