p21 governs p53's repressive side
Open accessAbstract
The tumor suppressor p53 is the most studied gene and protein in literature. Before p53 became the best known tumor suppressor, it was mistakenly discovered as an oncogene.1 Cancer typically evades...
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In general, p21 is required for p53-dependent gene downregulation.
“Recent results from p21-knockout cells show that, in general, p21 is required for p53-dependent gene downregulation.18, 116”
From Census and evaluation of p53 target genes (2017) · cites this paper as [116]
Gene downregulation by p53 is indirect and requires p21.
“Gene downregulation by p53 is indirect and requires p21. 18, 116”
From Census and evaluation of p53 target genes (2017) · cites this paper as [116]
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Cites
The first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967 · see citing works
MicroRNAs in the p53 network: micromanagement of tumour suppression
Hermeking, H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3318 · Cited by 518 · see citing works
Fischer, M., Grossmann, P., Padi, M., & DeCaprio, J. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw523 · Cited by 330 · see citing works
Self-citationThe p53-p21-DREAM-CDE/CHR pathway regulates G 2 /M cell cycle genes
Fischer, M., Quaas, M., Steiner, L., & Engeland, K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv927 · Cited by 324 · see citing works
Self-citationThe transcription factor p53: Not a repressor, solely an activator.
Fischer, M., Steiner, L., & Engeland, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.949083 · Cited by 153 · see citing works
Self-citationExpanding the p53 regulatory network: LncRNAs take up the challenge
Grossi, E., Sánchez, Y., & Huarte, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.011 · Cited by 78 · see citing works
Fischer, M., Quaas, M., Nickel, A., & Engeland, K. (2015) · Oncotarget · doi:10.18632/oncotarget.6356 · Cited by 59 · see citing works
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Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
Self-citationYeo-Teh, N. S. L., Ito, Y., & Jha, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061706 · Cited by 279 · see citing works
SOG1 activator and MYB3R repressors regulate a complex DNA damage network in Arabidopsis
Bourbousse, C., Vegesna, N., & Law, J. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810582115 · Cited by 152 · see citing works
Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway
Fischer, M., Uxa, S., Stanko, C., Magin, T. M., & Engeland, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-02831-9 · Cited by 108 · see citing works
Self-citationPuzio‐Kuter, A. M., Xu, L., McBrayer, M. K., Dominique, R., Li, H. H., Fahr, B. J., Brown, A. M., Wiebesiek, A. E., Russo, B. M., Mulligan, C. L., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-1421 · Cited by 71 · see citing works
TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation
Fischer, M., Schwarz, R. J., Riege, K., DeCaprio, J. A., & Hoffmann, S. (2022) · NAR Cancer · doi:10.1093/narcan/zcac009 · Cited by 47 · see citing works
Self-citationCommon Functions of Disordered Proteins across Evolutionary Distant Organisms
Wallmann, A., & Kesten, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062105 · Cited by 42 · see citing works
Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer
Chen, M.-C., Tsai, Y.-C., Tseng, J.-H., Liou, J., Horng, S., Wen, H.-C., Fan, Y.-C., Zhong, W.-B., & Hsu, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122690 · Cited by 32 · see citing works
Indeglia, A., & Murphy, M. E. (2024) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2024.2344465 · Cited by 27 · see citing works
Puf-A promotes cancer progression by interacting with nucleophosmin in nucleolus
Cho, H.-C., Huang, Y., Hung, J., Hung, T., Cheng, K., Liu, Y., Kuo, M.-W., Wang, S.-H., Yu, A. L.-T., & Yu, J. (2022) · Oncogene · doi:10.1038/s41388-021-02138-0 · Cited by 9 · see citing works
Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape
Liang, S., Ezerskyte, M., Wang, J., Pelechano, V., & Dreij, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-70412-4 · Cited by 3 · see citing works
The Tumor Suppressor p53 Downregulates p107 (RBL1) Through p21–RB/E2F Signaling and Tandem E2F Sites
Azzahrani, K., & Alqahtani, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209903 · Cited by 2 · see citing works
- Authors
- Fischer, M.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Fischer, Martin
- ORCID
- Fischer, Martin
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2016-07-27
- Volume
- 15
- Issue
- 21
- Pages
- 2852-2853
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC5105911
- OpenAlex
- W2473945701
- Cited by
- 12
- References
- 7
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2020: 2 · 2018: 2 · 2017: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- p21, p53, tumor suppressor, transcriptional repression, cell cycle regulation
- MeSH terms
- Tumor Suppressor Protein p53, Cyclin-Dependent Kinase Inhibitor p21
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