Cited by 220Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyRespiratory Support and Mechanisms

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Dyspnea and Activity Limitation in COPD: Mechanical Factors

O'Donnell, Denis E., Laveneziana, Pierantonio·2007·COPD: Journal of Chronic Obstructive Pulmonary Disease

DOI 10.1080/15412550701480455

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Abstract

Dyspnea and activity limitation are the primary symptoms of chronic obstructive pulmonary disease and progress relentlessly as the disease advances. In COPD, dyspnea is multifactorial but abnormal dynamic ventilatory mechanics are believed to be important. Dynamic lung hyperinflation occurs during exercise in the majority of flow-limited patients with chronic obstructive pulmonary disease and may have serious sensory and mechanical consequences. This proposition is supported by several studies, which have shown a close correlation between indices of dynamic lung hyperinflation and measures of both exertional dyspnea and exercise performance. The strength of this association has been further confirmed by studies that have therapeutically manipulated this dependent variable. Relief of exertional dyspnea and improved exercise endurance following bronchodilator therapy correlate well with reduced lung hyperinflation. The mechanisms by which dynamic lung hyperinflation give rise to exertional dyspnea and exercise intolerance are complex. However, recent mechanistic studies suggest that dynamic lung hyperinflation-induced volume restriction and consequent neuromechanical uncoupling of the respiratory system are key mechanisms. This review examines, in some detail, the derangements of ventilatory mechanics that are peculiar to chronic obstructive pulmonary disease and attempts to provide a mechanistic rationale for the attendant respiratory discomfort and activity limitation.

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Self-citation
Pain intensity processing within the human brain: a bilateral, distributed mechanism
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Self-citation
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O'DONNELL, D. E., LAM, M., & WEBB, K. A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9804004 · Cited by 532 · cited 3×
“The rate and magnitude of DH during exercise is generally measured in the laboratory setting by serial inspiratory capacity (IC) measurements (3, 14, 25).”
BackgroundMethodSelf-citation
Spirometric Correlates of Improvement in Exercise Performance after Anticholinergic Therapy in Chronic Obstructive Pulmonary Disease
O'DONNELL, D. E., LAM, M., & WEBB, K. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.2.9901038 · Cited by 485
Self-citation
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O’Donnell, D. E., Bertley, J. C., Chau, L. K. L., & Webb, K. A. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001298 · Cited by 432
Self-citation

Show all 91 references

Research works printed but not linked: 13

O'Donnell D E, 1995, Current Therapy in Sports Medicine, 3rd ed, 678
Pride N B, 1986, Handbook of Physiology, Section 3, Vol III, Part 2: The Respiratory System, 659
Druz W S, 1981, J Appl Physiol, 51, 1522
Dodd D S, 1984, Am Rev Respir Dis, 129, 33
10.1183/09031936.04.00072703 · DOI · Paper page
Light R W, 1984, Am Rev Respir Dis, 130, 391
10.1164/ajrccm/151.3_Pt_1.751 · DOI
Hong H, 1999, Am J Respir Crit Care Med, 159, A787
Altose M D, 1989, Proc Int Union Physiol Sci, 17, 288
Killian K J, 1985, Lung Biology in Health and Disease, vol 29, part B: The Thorax, 787
Grassino A, 1979, Bull Eur Pathophysiol Respir, 15, 105
Bye P T, 1985, Am Rev Respir Dis, 32, 236
Kukorelli T, 1969, Acta Physiol Acad Sci Hung, 36, 261

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Authors: O'Donnell, D. E., & Laveneziana, P.
Affiliations: Queen's University (CA)
ORCID: Laveneziana, Pierantonio
Venue: COPD: Journal of Chronic Obstructive Pulmonary Disease
Publisher: Informa UK Limited
Published: 2007-01
Volume: 4
Issue: 3
Pages: 225-236
ISSN: 1541-2555 (ISSN-L)
1541-2563
DOI: 10.1080/15412550701480455
OpenAlex: W2158320806
Cited by: 220
References: 91
Citations by year: 2026: 12 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 15 · 2020: 22 · 2019: 17 · 2018: 16 · 2017: 14 · 2016: 11 · 2015: 19 · 2014: 12 · 2013: 10 · 2012: 12
FWCI: 4.34
Type: journal article
Language: en
Open access: closed
Locations: COPD Journal of Chronic Obstructive Pulmonary Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords: chronic obstructive pulmonary disease, dyspnea, exertional dyspnea, activity limitation, respiratory mechanics, exercise intolerance, bronchodilator therapy
MeSH terms: Dyspnea, Humans, Pulmonary Ventilation, Total Lung Capacity, Respiratory Mechanics, Exercise Tolerance, Pulmonary Disease, Chronic Obstructive

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Dyspnea and Activity Limitation in COPD: Mechanical Factors

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