Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

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Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs

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The RNA modification database, RNAMDB: 2011 update

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Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae

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Specialized ribosomes: a new frontier in gene regulation and organismal biology

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Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions

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Ribosome Biogenesis Alterations in Colorectal Cancer

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Ribosome biogenesis and cancer: basic and translational challenges

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Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing

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Insights into RNA-processing pathways and associated RNA-degrading enzymes in Archaea

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LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice

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Principles of human pre-60 S biogenesis

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The protective role of m1A during stress-induced granulation

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snoDB 2.0: an enhanced interactive database, specializing in human snoRNAs

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IGF2BP3 promotes mRNA degradation through internal m7G modification

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The emerging impact of tRNA modifications in the brain and nervous system

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Genes with 5′ terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 Nsp1 protein

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uORF-mediated translational control: recently elucidated mechanisms and implications in cancer

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The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation

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Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function

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A roadmap for rRNA folding and assembly during transcription

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m1A RNA Modification in Gene Expression Regulation

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The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA

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A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes

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RNA dysregulation in neurodegenerative diseases

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Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA

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Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function

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N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis

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RNA Polymerases I and III in development and disease

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The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

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NHP2 deficiency impairs rRNA biogenesis and causes pulmonary fibrosis and Høyeraal–Hreidarsson syndrome

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Classification and function of RNA –protein interactions

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SnoRNA signatures in cartilage ageing and osteoarthritis

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RNA Modifications: Reversal Mechanisms and Cancer

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N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance

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TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA

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m7GHub V2.0: an updated database for decoding the N7-methylguanosine (m7G) epitranscriptome

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RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives

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Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation

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Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs

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Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo

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Mettl5 mediated 18S rRNA N6-methyladenosine (m6A) modification controls stem cell fate determination and neural function

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Detecting the epitranscriptome

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The Functions of Non-coding RNAs in rRNA Regulation

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METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression

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Constitutive and variable 2’-O-methylation (Nm) in human ribosomal RNA

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Maturation of small nucleolar RNAs: from production to function

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Modificaomics: deciphering the functions of biomolecule modifications

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The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?

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Ribosome Biogenesis in Archaea

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Formation and removal of 1,N6-dimethyladenosine in mammalian transfer RNA

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Nucleotide resolution sequencing of N4-acetylcytidine in RNA

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The role of OncoSnoRNAs and Ribosomal RNA 2’-O-methylation in Cancer

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Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

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Quantifying RNA modifications by mass spectrometry: a novel source of biomarkers in oncology

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Comprehensive Evaluation and Analysis of the Mechanism of Cold Tolerance Based on the Transcriptome of Weedy Rice Seedlings

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Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions

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RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes

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Hypoxia re-programs 2′-O-Me modifications on ribosomal RNA

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Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing

Zhou, K. I., Clark, W. C., Pan, D. W., Eckwahl, M. J., Dai, Q., & Pan, T. (2018) · RNA Biology · doi:10.1080/15476286.2018.1462654 · Cited by 43

N 1-methyladenosine (m1A) RNA modification: the key to ribosome control

Shima, H., & Igarashi, K. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa026 · Cited by 43

LncRNAs: the good, the bad, and the unknown

Arunkumar, G. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2023-0155 · Cited by 42

The emerging importance of METTL5-mediated ribosomal RNA methylation

Turkalj, E. M., & Vissers, C. B. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00869-y · Cited by 40

Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance

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Single-particle mass analysis of intact ribosomes by mass photometry and Orbitrap-based charge detection mass spectrometry

Lai, S., Tamara, S., & Heck, A. J. R. (2021) · iScience · doi:10.1016/j.isci.2021.103211 · Cited by 46

Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes

Ali, A. T., Idaghdour, Y., & Hodgkinson, A. (2020) · Communications Biology · doi:10.1038/s42003-020-0879-3 · Cited by 41

METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue

Laptev, I. G., Shvetsova, E., Левицкий, С. А., Serebryakova, M. V., Rubtsova, M. P., Zgoda, V. G., Bogdanov, A. A., Kamenski, P. A., Владимирович, С. П., & Dontsova, O. А. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa522 · Cited by 40

A Census and Categorization Method of Epitranscriptomic Marks

Mathlin, J., Pera, L. L., & Colombo, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134684 · Cited by 41

A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome

Yelland, J. N., Bravo, J. P. K., Black, J. J., Taylor, D. W., & Johnson, A. M. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00891-8 · Cited by 46

Soybean Oil and Protein: Biosynthesis, Regulation and Strategies for Genetic Improvement

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A subcellular map of translational machinery composition and regulation at the single-molecule level

Zhang, Z., Xu, A., Bai, Y., Chen, Y., Cates, K., Kerr, C. H., Bermudez, A., Susanto, T. T., Wysong, K., Garcia-Marques, F. J., et al. (2025) · Science · doi:10.1126/science.adn2623 · Cited by 38

The Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy and Drug Resistance

Wood, S., Willbanks, A. R., & Cheng, J. X. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621666210127092828 · Cited by 37

Widespread genetic heterogeneity of human ribosomal RNA genes

Fan, W., Eklund, E., Sherman, R. M., Liu, H., Pitts, S. C., Ford, B. L., Rajeshkumar, N. V., & Laiho, M. (2022) · RNA · doi:10.1261/rna.078925.121 · Cited by 38

Visualizing the Role of 2’-OH rRNA Methylations in the Human Ribosome Structure

Natchiar, S. K., Myasnikov, A. G., Hazemann, I., & Klaholz, B. P. (2018) · Biomolecules · doi:10.3390/biom8040125 · Cited by 44

Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins

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Mapping rRNA 2’-O-methylations and identification of C/D snoRNAs in Arabidopsis thaliana plants

Azevedo, J., Gaspin, C., Ayadi, L., Montacié, C., Marchand, V., Jobet, E., Rompais, M., Carapito, C., Motorin, Y., & Sáez‐Vasquez, J. (2021) · RNA Biology · doi:10.1080/15476286.2020.1869892 · Cited by 37

Ribosomal control in RNA virus-infected cells

Wang, X., Zhu, J., Zhang, D., & Liu, G. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1026887 · Cited by 37

Hypoxia induces alterations in tRNA modifications involved in translational control

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SnoRNAs and the emerging class of sdRNAs: Multifaceted players in oncogenesis

Abel, Y., & Rederstorff, M. (2019) · Biochimie · doi:10.1016/j.biochi.2019.05.006 · Cited by 38

Aging through an epitranscriptomic lens

McMahon, M. E., Forester, C. M., & Buffenstein, R. (2021) · Nature Aging · doi:10.1038/s43587-021-00058-y · Cited by 34

The role of RNA modification in hepatocellular carcinoma

Feng, Q., Wang, D., Xue, T., Lin, C., Gao, Y., Sun, L., Jin, Y., & Liu, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.984453 · Cited by 37

Dynamic rRNA modifications as a source of ribosome heterogeneity

Milenkovic, I., & Novoa, E. M. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.10.001 · Cited by 37

Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases

Bonnet, S., Boucherat, O., Paulin, R., Wu, D., Hindmarch, C. C. T., Archer, S. L., Song, R., Moore, J. B., Provencher, S., Zhang, L., et al. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00078.2019 · Cited by 34

Emerging Classes of Small Non-Coding RNAs With Potential Implications in Diabetes and Associated Metabolic Disorders

Jacovetti, C., Bayazit, M. B., & Regazzi, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.670719 · Cited by 37

The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly

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High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation

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