The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function
Open accessAbstract
rRNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilize the structure of the ribosome. However, they also cluster at functionally important sites of the ribosome, such as the peptidyltransferase center and the decoding site, where they facilitate efficient and accurate protein synthesis. The recent identification of sites of substoichiometric 2'-O-methylation and pseudouridylation has overturned the notion that all rRNA modifications are constitutively present on ribosomes, highlighting nucleotide modifications as an important source of ribosomal heterogeneity. While the mechanisms regulating partial modification and the functions of specialized ribosomes are largely unknown, changes in the rRNA modification pattern have been observed in response to environmental changes, during development, and in disease. This suggests that rRNA modifications may contribute to the translational control of gene expression.
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“Recent data suggest that the pattern of rRNA modification may change during periods of cellular growth, including modifications catalyzed by complexes such as dyskerin (DKC1) [190,192].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [190]
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“As discussed above, snoRNAs guide site-specific cleavage and chemical modification of the 45S pre-rRNA, thereby contributing to proper ribosomal subunit maturation [190].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [190]
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“Before maturation, this precursor transcript is subject to more than 200 site-specific modifications, predominantly 2′-O-methylation and pseudouridylation [190].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [190]
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Metadata
- Authors
- Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Université Libre de Bruxelles (BE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Bohnsack, Markus T.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2016-12-18
- Volume
- 14
- Issue
- 9
- Pages
- 1138-1152
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- PMC
- PMC5699541
- OpenAlex
- W2557904026
- Cited by
- 707
- References
- 155
- Citations by year
- 2026: 63 · 2025: 64 · 2024: 81 · 2023: 101 · 2022: 90 · 2021: 90 · 2020: 96 · 2019: 57 · 2018: 47 · 2017: 15
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- RNA Biology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- rRNA modification, ribosome biogenesis, 80S ribosome, 2'-O-methylation, pseudouridylation, peptidyl transferase center, decoding site, translational regulation, ribosome structure, nucleolus
- MeSH terms
- Acetylation, Animals, Disease Susceptibility, Eukaryotic Cells, Humans, Methylation, Ribosomes, RNA, Ribosomal, Structure-Activity Relationship, RNA, Small Nucleolar
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