Cited by 727RNA modifications and cancerRNA and protein synthesis mechanismsRNA regulation and disease

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Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

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Sloan, Katherine E., Warda, Ahmed S., Sharma, Sunny, Entian, Karl-Dieter, Lafontaine, Denis L. J., Bohnsack, Markus T.·2017·RNA Biology

DOI 10.1080/15476286.2016.1259781PMC PMC5699541

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Abstract

rRNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilize the structure of the ribosome. However, they also cluster at functionally important sites of the ribosome, such as the peptidyltransferase center and the decoding site, where they facilitate efficient and accurate protein synthesis. The recent identification of sites of substoichiometric 2'-O-methylation and pseudouridylation has overturned the notion that all rRNA modifications are constitutively present on ribosomes, highlighting nucleotide modifications as an important source of ribosomal heterogeneity. While the mechanisms regulating partial modification and the functions of specialized ribosomes are largely unknown, changes in the rRNA modification pattern have been observed in response to environmental changes, during development, and in disease. This suggests that rRNA modifications may contribute to the translational control of gene expression.

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Figure 1. Structures of box C/D and box H/ACA sRNP complexes. (A) Structural model of an H/ACA box sRNP from Pyrococcus furiosus (PDB 3HAY)154 A surface view of the protein components is shown and sRNA and rRNA are indicated in dark gray and red, respectively. (B) Structural model of a Sulfolobus solfataricus box C/D sRNP (PDB 3PLA)155 is shown as in A. The modified nucleotide is shown in surface view. Note, that archaeal L7Ae is an ortholog of eukaryotic Snu13 and in eukaryotes, Nop56 and Nop58 are orthologous to archaeal Nop5.CC BY-NC-ND · PubMed Central

Figure 2. Base modifications in rRNA and the enzymes that install them. (A) Chemical structures of the 4 nucleotides and the modifications that are added in yeast rRNAs. The additional chemical groups are marked in red and the enzymes that introduce them in yeast are indicated above the arrow (yellow) and in humans below the arrow (green). (B) Three-step modification pathway for U1191 of the 18S rRNA in yeast.CC BY-NC-ND · PubMed Central

Figure 3. Distribution of rRNA modifications on the yeast ribosome. The S. cerevisiae 80S ribosome (PBD 4V88)6 is shown – 40S in teal and 60S in gray. The positions of 2′-O-methylations (purple), pseudouridines (blue) and base modification installed by stand-alone enzymes (orange) are indicated. Three functionally important regions of the ribosome, the peptidyltransferase center (PTC), the decoding site and the intersubunit bridge eB14, are also shown in a magnified view.CC BY-NC-ND · PubMed Central

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Fu, Y., Dominissini, D., Rechavi, G., & He, C. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3724 · Cited by 1,961
The Structure of the Eukaryotic Ribosome at 3.0 Å Resolution
Shem, A. B., de Loubresse, N. G., Melnikov, S. V., Jenner, L. B., Yusupova, G. Z., & Yusupov, M. (2011) · Science · doi:10.1126/science.1212642 · Cited by 1,187
Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
Carlile, T. M., Rojas-Durán, M. F., Zinshteyn, B., Shin, H., Bartoli, K. M., & Gilbert, W. V. (2014) · Nature · doi:10.1038/nature13802 · Cited by 1,042
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
Schwartz, S., Bernstein, D. A., Mumbach, M. R., Jovanović, M., Herbst, R. H., León-Ricardo, B. X., Engreitz, J., Guttman, M., Satija, R., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.028 · Cited by 1,013
MODOMICS: a database of RNA modification pathways—2013 update
Machnicka, M. A., Milanowska, K., Oglou, O. O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K. M., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1007 · Cited by 1,003
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
Heiss, N. S., Knight, S. W., Vulliamy, T. J., Klauck, S. M., Wiemann, S., Mason, P. J., Poustka, A., & Dokal, I. (1998) · Nature Genetics · doi:10.1038/ng0598-32 · Cited by 976
Site-Specific Ribose Methylation of Preribosomal RNA: A Novel Function for Small Nucleolar RNAs
Kiss-László, Z., Henry, Y. A. L., Bachellerie, J., Caizergues‐Ferrer, M., & Kiss, T. (1996) · Cell · doi:10.1016/s0092-8674(00)81308-2 · Cited by 855
The RNA modification database, RNAMDB: 2011 update
Cantara, W. A., Crain, P. F., Rozenski, J., McCloskey, J. A., Harris, K. A., Zhang, X., Vendeix, F. A. P., Fabris, D., & Agris, P. F. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1028 · Cited by 822
Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae
Woolford, J. L., & Baserga, S. J. (2013) · Genetics · doi:10.1534/genetics.113.153197 · Cited by 780
Specialized ribosomes: a new frontier in gene regulation and organismal biology
Xue, S., & Barna, M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3359 · Cited by 730

Show all 155 references

Research works printed but not linked: 2

Enright CA, 1996, RNA, 2, 1094
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Yang, J., Wang, Y., Huang, Z., Jiang, Y., Pan, X., Dong, X., & Yang, G. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3891 · Cited by 5
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Meng, Z., Li, X., Lu, S., Hua, Y., Yin, B., Qian, B., Li, Z., Zhou, Y., Sergeeva, I., Fu, Y., et al. (2024) · European journal of medical research · doi:10.1186/s40001-024-01928-y · Cited by 5
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Fluke, K. A., Dai, N., Wolf, E. J., Fuchs, R. T., Ho, P. S., Talbott, V., Elkins, L., Tsai, Y.-L., Schiltz, J., Febvre, H. P., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405999121 · Cited by 4
The non-canonical nucleotides and prebiotic evolution
Ruzov, A. S., & Ermakov, A. S. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105411 · Cited by 4
Analysis and Comparison of RNA Pseudouridine Site Prediction Tools
Chen, W., & Liu, K. (2019) · Current Bioinformatics · doi:10.2174/1574893614666191018171521 · Cited by 4
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Han, B., Xi, W., Hong, Y., Gu, L., Chao, Y., Li, L., Liu, C., Li, Y., Chao, J., & Yao, H. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108254 · Cited by 4
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Kapinová, A., Mazuráková, A., Halášová, E., Daňková, Z., Büsselberg, D., Costigliola, V., Golubnitschaja, O., & Kubatka, P. (2023) · The EPMA Journal · doi:10.1007/s13167-023-00323-7 · Cited by 4
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Kawata, K., & Akimitsu, N. (2021) · RNA technologies · doi:10.1007/978-3-030-71612-7_8 · Cited by 4
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Thomé, C. C., Lemus-Diaz, N., von Blottnitz, K. I. B., Tagnères, S., Helmkamp, M. K., Honemann‐Capito, M., Hackert, P., Moshkovskii, S. A., Lenz, C., Bohnsack, M. T., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag154 · Cited by 3
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Chen, J., Li, Y., Wang, Y., Wang, H., Yang, J., Pan, X., Zhao, Y. S., Xu, H., Jiang, P., Qian, P., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00315-x · Cited by 3
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Qiu, X., Tian, J., Zhao, X., Wang, L., Wang, L., Bai, Y., Sun, A., & Zhuang, G. (2025) · Transboundary and Emerging Diseases · doi:10.1155/tbed/8542827 · Cited by 3
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Gao, Y., Karasawa, M., Quan, Z., Mori, T., Kanaida, M., Townsend, C. A., Terada, T., Abe, I., & Awakawa, T. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c08367 · Cited by 3
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Åsman, A. K. M., Curtis, B. A., & Archibald, J. M. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz064 · Cited by 3
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Yang, J., Watzinger, P., & Sharma, S. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2501-9_11 · Cited by 3
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Kilar, A., Fajkus, P., & Fajkus, J. (2022) · GigaScience · doi:10.1093/gigascience/giad080 · Cited by 3
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Solari, C. A., Martínez, M. C. O., Fernández, J. M., Bates, C., Cueto, G., Valacco, P., Morales-Polanco, F., Moreno, S., Rossi, S., Ashe, M., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108727 · Cited by 3
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Neumann, S. A., Gaspin, C., & Sáez‐Vasquez, J. (2024) · RNA Biology · doi:10.1080/15476286.2024.2417152 · Cited by 3
Small nucleolar RNAs: the hidden precursors of cancer ribosomes.
Faucher‐Giguère, L., de Préval, B. S., Rivera, A., Scott, M. S., & Elela, S. A. (2025) · PubMed · doi:10.1098/rstb.2023.0376 · Cited by 3
Pervasive Small RNAs in Cardiometabolic Research: Great Potential Accompanied by Biological and Technical Barriers
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Authors: Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T.
Affiliations: Universitätsmedizin Göttingen (DE)
Université Libre de Bruxelles (BE)
Goethe University Frankfurt (DE)
Corresponding author: Bohnsack, Markus T.
ORCID: Sharma, Sunny
Lafontaine, Denis L. J.
Bohnsack, Markus T.
Venue: RNA Biology
Publisher: Informa UK Limited
Published: 2016-12-18
Volume: 14
Issue: 9
Pages: 1138-1152
ISSN: 1547-6286 (ISSN-L)
1555-8584
DOI: 10.1080/15476286.2016.1259781
PMC: PMC5699541
OpenAlex: W2557904026
Cited by: 707
References: 155
Citations by year: 2026: 63 · 2025: 64 · 2024: 81 · 2023: 101 · 2022: 90 · 2021: 90 · 2020: 96 · 2019: 57 · 2018: 47 · 2017: 15
FWCI: 3.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: RNA Biology (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: rRNA modification, ribosome biogenesis, 80S ribosome, 2'-O-methylation, pseudouridylation, peptidyl transferase center, decoding site, translational regulation, ribosome structure, nucleolus
MeSH terms: Acetylation, Animals, Disease Susceptibility, Eukaryotic Cells, Humans, Methylation, Ribosomes, RNA, Ribosomal, Structure-Activity Relationship, RNA, Small Nucleolar

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Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

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