How autophagy both activates and inhibits cellular senescence
Open accessAbstract
Autophagy and cellular senescence are stress responses essential for homeostasis. While recent studies indicate a genetic relationship between autophagy and senescence, whether autophagy acts positively or negatively on senescence is still subject to debate. Although autophagy was originally recognized as a nonspecific lysosomal degradation pathway (general autophagy), increasing evidence supports a selective form of autophagy that mediates the degradation of specific targets (selective autophagy). Our recent study revealed distinctive roles of selective autophagy and general autophagy in the regulation of senescence, at least in part resolving apparently contradictory reports regarding the relationship between these 2 important homeostatic stress responses.
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Senescent cells are generally characterized by increased lysosomal content occurring as a consequence of defective lysosomal turnover or of multi-faceted changes in autophagy.
“Senescent cells are generally characterized by increased lysosomal content occurring as a consequence of defective lysosomal turnover24 or of multi-faceted changes in autophagy25.”
From Algorithmic assessment of cellular senescence in experimental and clinical specimens (2021) · cites this paper as [25]
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Self-citationThe metabolic roots of senescence: mechanisms and opportunities for intervention
Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00483-8 · Cited by 691 · see citing works
Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works
Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy
Saleh, T., Bloukh, S., Carpenter, V. J., Alwohoush, E., Bakeer, J., Darwish, S., Azab, B., & Gewirtz, D. A. (2020) · Cancers · doi:10.3390/cancers12040822 · Cited by 289 · see citing works
Molecular mechanisms of aging and anti-aging strategies
Li, Y., Tian, X., Luo, J., Bao, T., Wang, S., & Wu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01663-1 · Cited by 333 · see citing works
“Increasing evidence indicates that intracellular lysosomal proteolytic function is impaired with aging in various model organisms, which impairs autophagic flux, exacerbates cell damage, and promotes the occurrence of aging-related diseases [155].”
BackgroundCavinato, M., & Jansen-Dürr, P. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.009 · Cited by 284 · see citing works
Molecular mechanisms of renal aging
Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235 · see citing works
“The level of autophagic flux, on the other hand, might directly regulate crucial senescence features, such as the SASP.(90) In addition, the consequences of autophagy for senescence induction are highly variable: ablation of Atg5 limited to the S3 segment of the proximal tubule resulted in protection from postischemic…”
BackgroundInfluentialWang, Y., Wang, L., Wen, X., Hao, D., Zhang, N., He, G., & Jiang, X. L. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111160 · Cited by 231 · see citing works
The multifaceted role of autophagy in cancer and the microenvironment
Folkerts, H., Hilgendorf, S., Vellenga, E., Bremer, E., & Wiersma, V. R. (2018) · Medicinal Research Reviews · doi:10.1002/med.21531 · Cited by 201 · see citing works
“An important process in ageing is cellular senescence, a stress response of damaged or aged cells characterized by permanent cell cycle arrest.(313) Like senescence, autophagy is a pathway that is activated upon cellular stress, and both pathways appear connected.”
BackgroundSpermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
Xu, T., Li, H., Dai, Z., Lau, G. K., Li, B., Zhu, W., Liu, X.-Q., Liu, H.-F., Cai, W.-W., Huang, S., et al. (2020) · Aging · doi:10.18632/aging.103035 · Cited by 204 · see citing works
“com 6402 AGING disease and anti-aging [15].”
Senescence in osteoarthritis: from mechanism to potential treatment
Liu, Y., Zhang, Z., Li, T., Xu, H., & Zhang, H. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02859-x · Cited by 206 · see citing works
Algorithmic assessment of cellular senescence in experimental and clinical specimens
Kohli, J., Wang, B., Brandenburg, S. M., Basisty, N., Evangelou, K., Varela-Eirin, M., Campisi, J., Schilling, B., Gorgoulis, V., & Demaria, M. (2021) · Nature Protocols · doi:10.1038/s41596-021-00505-5 · Cited by 196 · see citing works
Senescence in the pathogenesis of age-related macular degeneration
Blasiak, J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03420-x · Cited by 183 · see citing works
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188 · see citing works
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives
Zhang, M., Salas, S. S., Damba, T., Borghesan, M., Demaria, M., & Moshage, H. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111572 · Cited by 180 · see citing works
“The role of macroautophagy in senescence is complex, which is underscored by the phenomenon that both increasing as well as decreasing autophagy induces senescence (Kang and Elledge, 2016).”
The role of autophagy in resistance to targeted therapies
Mele, L. L., Vecchio, V. D., Liccardo, D., Prisco, C., Schwerdtfeger, M., Robinson, N., Desiderio, V., Tirino, V., Papaccio, G., & Noce, M. L. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102043 · Cited by 178 · see citing works
Autophagy drives fibroblast senescence through MTORC2 regulation
Bernard, M., Yang, B., Migneault, F., Turgeon, J., Dieudé, M., Olivier, M., Cardin, G. B., El-Diwany, M., Underwood, K., Rodier, F., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1713640 · Cited by 174 · see citing works
“Studies on cross-talk between autophagy and senescence in fibroblasts show contradictory context-dependent results [18,19].”
BackgroundAntioxidative nanomaterials and biomedical applications
Liu, Y., & Shi, J. (2019) · Nano Today · doi:10.1016/j.nantod.2019.05.008 · Cited by 173 · see citing works
Liu, F., Yuan, Y., Bai, L., Yuan, L., Li, L., Liu, J., Chen, Y., Lu, Y., Cheng, J., & Zhang, J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101963 · Cited by 162 · see citing works
“Autophagy is an intracellular degradation system with multiple pathophysiological and physiological functions [41].”
BackgroundCellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 169 · see citing works
Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot
Yoojin, K., Kim, J. W., Jeoung, J. A., Kim, M.-S., & Kang, C. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.0151 · Cited by 150 · see citing works
“…a major lysosomal degradation pathway, was originally recognized as a response to starvation, recycling cellular components to maintain energy homeostasis (Boya et al., 2013; Choi et al., 2013; Kang and Avery, 2008; 2009a; 2009b; Kang et al., 2007; Klionsky and Codogno, 2013; Kroemer et al., 2010).”
BackgroundSelf-citationCortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, C., Maciel-Barón, L. A., Konigsberg, M., Massieu, L., & Castro-Obregón, S. (2019) · Aging · doi:10.18632/aging.102181 · Cited by 128 · see citing works
Autophagy and senescence: A new insight in selected human diseases
Rajendran, P., Alzahrani, A. M., Hanieh, H., Kumar, S. A., Ammar, R. B., Rengarajan, T., & Alhoot, M. A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28895 · Cited by 121 · see citing works
Kang, C. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.0298 · Cited by 125 · see citing works
“Elucidating how selective autophagy regulates GATA4 will be helpful to design for specifically targeting the GATA4-SASP pathway without disruption of its developmental roles (Kang and Elledge, 2016; Kwon et al., 2017; Mazzucco et al., 2017).”
BackgroundSelf-citationA common signature of cellular senescence; does it exist?
Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101458 · Cited by 120 · see citing works
Cellular senescence: a promising strategy for cancer therapy
Lee, S., & Lee, J. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.294 · Cited by 114 · see citing works
“observed in senescent cells, their relationship remains poorly defined (14, 57, 58).”
BackgroundRole of autophagy in aging: The good, the bad, and the ugly
TABIBZADEH, S. S. (2022) · Aging Cell · doi:10.1111/acel.13753 · Cited by 103 · see citing works
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function
Guo, J., Ren, R., Sun, K., Yao, X., Lin, J., Wang, G., Guo, Z., Xu, T., & Guo, F. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03046-z · Cited by 96 · see citing works
JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy
Lin, Z., Miao, J., Zhang, T., He, M., Wang, Z.-Y., Feng, X., & Bai, L. (2021) · Aging Cell · doi:10.1111/acel.13306 · Cited by 89 · see citing works
“…reports have implied that ERK has little effect on cartilage matrix metabolism (Latourte et al., 2017; Prasadam et al., 2010, 2013); on the contrary, autophagy can upregulate anabolism, alleviate apoptosis and downregulate catabolism in the late stage of OA (Kang & Elledge, 2016; Li et al., 2016).”
BackgroundZhang, Z., Yao, Z., Zhao, S., Shao, J., Chen, A., Zhang, F., & Zheng, S. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.255 · Cited by 97 · see citing works
Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy
Guo, J., Zou, Y., & Huang, L. (2023) · Small Methods · doi:10.1002/smtd.202201307 · Cited by 91 · see citing works
Błasiak, J., Piechota, M. J., Pawłowska, E., Szatkowska, M., Sikora, E., & Kaarniranta, K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5293258 · Cited by 92 · see citing works
Senescence of alveolar epithelial progenitor cells: a critical driver of lung fibrosis
Parimon, T., Chen, P., Stripp, B. R., Liang, J., Jiang, D., Noble, P. W., Parks, W. C., & Yao, C. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00239.2023 · Cited by 92 · see citing works
mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
Cayo, Á., Segovia, R., Venturini, W., Moore‐Carrasco, R., Valenzuela, C. A., & Brown, N. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158149 · Cited by 92 · see citing works
Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential
He, Y., Xie, W., Li, H., Jin, H., Zhang, Y., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.793088 · Cited by 82 · see citing works
“Moreover, a key regulator of the SASP, GATA4, whose degradation can be mediated by autophagic receptor protein SQSTM1/p62, would accumulate by escaping from autophagic inhibition through decreased interaction between GATA4 and SQSTM1, and eventually initiate the SASP by activating NF-κB (Kang and Elledge, 2016).”
BackgroundInfluentialD’Adamo, S., Cetrullo, S., Guidotti, S., Silvestri, Y., Minguzzi, M., Santi, S., Cattini, L., Filardo, G., Flamigni, F., & Borzı̀, R. M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.029 · Cited by 81 · see citing works
“Despite recent work has warned that autophagy might play both anti-senescence and pro-senescence roles, in a context specific manner [28,29], in most cases autophagy plays cell protective and anti-inflammatory effects, provided the functionality of downstream autophagic flux.”
BackgroundNan, L., Guo, P., Hui, W., Xia, F., & Yi, C. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1592596 · Cited by 84 · see citing works
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Sahu, M. R., Rani, L., Subba, R., & Mondal, A. C. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111675 · Cited by 75 · see citing works
The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death
Prokhorova, E. A., Egorshina, A. Y., Zhivotovsky, B., & Kopeina, G. S. (2019) · Oncogene · doi:10.1038/s41388-019-0980-6 · Cited by 77 · see citing works
Coordinate regulation of the senescent state by selective autophagy
Lee, Y., Kim, J., Kim, M.-S., Yoojin, K., Shin, S., Yi, H., Kim, H., Chang, M. J., Chang, C. B., Kang, S., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.008 · Cited by 75 · see citing works
Self-citationAdipose Tissue Senescence and Inflammation in Aging is Reversed by the Young Milieu
Ghosh, A. K., O’Brien, M., Mau, T., Qi, N., & Yung, R. L. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly290 · Cited by 72 · see citing works
Beauvarlet, J., Bensadoun, P., Darbo, E., Labrunie, G., Rousseau, B., Richard, E., Draskovic, I., Londono-Vallejo, A., Dupuy, J.-W., Nath Das, R., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz095 · Cited by 73 · see citing works
The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal
Ashraf, H. M., Fernandez, B., & Spencer, S. L. (2023) · Nature Communications · doi:10.1038/s41467-023-40132-0 · Cited by 74 · see citing works
Yanagi, S., Tsubouchi, H., Miura, A., Matsuo, A., Matsumoto, N., & Nakazato, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030503 · Cited by 69 · see citing works
Liu, A., Guo, E., Yang, J., Yang, Y., Liu, S., Jiang, X., Hu, Q. Z., Dirsch, O., Dahmen, U., Zhang, C., et al. (2017) · Aging Cell · doi:10.1111/acel.12708 · Cited by 70 · see citing works
“A similar “rejuvenating” effect of young blood has been demonstrated in other organs, including the spinal cord (Ruckh et al., 2012), heart (Loffredo et al., 2013), brain (Katsimpardi et al., 2014) (Villeda et al., 2014), b-cells (Salpeter et al., 2013), and hair follicles (Keyes et al., 2013).”
BackgroundLiang, S., Wu, Y.-S., Li, D.-Y., Tang, J., & Liu, H. (2022) · Aging and Disease · doi:10.14336/ad.2021.1027 · Cited by 66 · see citing works
“Because of autophagy could both activate and inhibit cellular senescence [145], which probably causing the opposite results about the role of RTECs autophagy in renal fibrosis in different mouse model.”
BackgroundResultInfluentialDual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence
Rastaldo, R., Vitale, E., & Giachino, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00276 · Cited by 66 · see citing works
Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies
Jiang, X., Li, W., Ge, L., & Lü, M. (2023) · Aging and Disease · doi:10.14336/ad.2023.0208 · Cited by 67 · see citing works
“Autophagy inhibits MSC senescence and promotes it by regulating rapamycin, optineurin, and p53 [69].”
BackgroundModerate hyperoxia induces senescence in developing human lung fibroblasts
You, K., Parikh, P., Khandalavala, K., Wicher, S. A., Manlove, L. J., Yang, B., Roesler, A., Roos, B. B., Teske, J. J., Britt, R. D., et al. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00067.2019 · Cited by 60 · see citing works
“Alterations in autophagy and ER stress have been reported in models of cellular senescence previously (3, 17).”
BackgroundZhang, D., Chen, Y., Xu, X., Xiang, H., Shi, Y., Gao, Y., Wang, X., Jiang, X., Li, N., & Pan, J. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13207 · Cited by 59 · see citing works
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Demirci, D., Dayanc, B., Mazi, F. A., & Şentürk, Ş. (2021) · Cells · doi:10.3390/cells10020208 · Cited by 60 · see citing works
Gut microbiota and anti-aging: Focusing on spermidine
Yu, L., Pan, J., Guo, M., Duan, H., Zhang, H., Narbad, A., Zhai, Q., Tian, F., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2224867 · Cited by 62 · see citing works
“Autophagy maintains overall cellular proteo-stasis and is directly involved in the decomposition of damaged, possibly toxic organelles and harmful protein aggregates, eliminating and recycling cytoplasmic waste that accumulates with aging (Kang and Elledge et al. 2016; Kim et al. 2021).”
Targeting normal and cancer senescent cells as a strategy of senotherapy
Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100941 · Cited by 57 · see citing works
Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
Zhou, S., Zhu, J., Zhou, P., & Gu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999600 · Cited by 57 · see citing works
“SASP develops gradually, triggering chronic inflammation and loss of tissue function, culminating in AT2 cell senescence and lung fibrosis (Kuilman et al., 2010; Kang and Elledge 2016; Liu et al., 2021).”
BackgroundVoronina, M. V., Frolova, A. S., Kolesova, E. P., Kuldyushev, N. A., Parodi, A., & Zamyatnin, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074087 · Cited by 57 · see citing works
“[162].”
BackgroundChakrabarty, A., Chakraborty, S., Bhattacharya, R., & Chowdhury, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.674354 · Cited by 56 · see citing works
“Similar to senescence, autophagy is stimulated by radiation, chemotherapy, telomere shortening, and oncogene activation, shares some common features, and serves similar cytoprotective roles (80, 81).”
BackgroundIncomplete autophagy: Trouble is a friend
Zhang, Q., Cao, S., Qiu, F., & Kang, N. (2022) · Medicinal Research Reviews · doi:10.1002/med.21884 · Cited by 54 · see citing works
Hou, J., Yun, Y. J., Xue, J., Jeon, B.-M., & Kim, S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6636 · Cited by 53 · see citing works
Zhou, L., Huo, M., Qian, X., Ding, L., Yu, L., Feng, W., Cui, X., & Chen, Y. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00855-y · Cited by 53 · see citing works
Neuronal Senescence in the Aged Brain
Chou, S.-M., Yen, Y., Yuan, F., Zhang, S., & Chong, C. (2023) · Aging and Disease · doi:10.14336/ad.2023.0214 · Cited by 54 · see citing works
McRobb, L. S., McKay, M. J., Gamble, J. R., Grace, M., Moutrie, V., Santos, E. D., Lee, V. S., Zhao, Z., Molloy, M. P., & Stoodley, M. A. (2017) · Aging · doi:10.18632/aging.101225 · Cited by 47 · see citing works
“While autophagy and senescence are often regarded as separate survival pathways, autophagy blockade can induce senescence in various cell types [32].”
BackgroundPotential Role of Cellular Senescence in Asthma
Wang, Z.-N., Su, R., Yang, B.-Y., Yang, K., Yang, L., Yan, Y., & Chen, Z. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00059 · Cited by 45 · see citing works
Valenti, M. T., Carbonare, L. D., Zipeto, D., & Mottes, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052700 · Cited by 47 · see citing works
“Although autophagy is generally considered to suppress cellular senescence, various studies have suggested that it may also promote it [92,93].”
BackgroundThe autophagic response to oxidative stress in osteoarthritic chondrocytes is deregulated
Goutas, A., Syrrou, C., Papathanasiou, I. V., Tsezou, A., & Trachana, V. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.003 · Cited by 46 · see citing works
Glioblastoma: Targeting the autophagy in tumorigenesis
Yang, K., Niu, L., Bai, Y., & Le, W. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.09.012 · Cited by 44 · see citing works
Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies
Xiao, M., Benoit, A., Hasmim, M., Duhem, C., Vogin, G., Berchem, G., Noman, M. Z., & Janji, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626309 · Cited by 44 · see citing works
“Indeed, the process of autophagy seems to both activates and inhibits cellular senescence (144), and chronic inhibition of autophagy appears to increase permanently the risk of cancer (145).”
BackgroundPantelis, P., Theocharous, G., Lаgopati, N., Veroutis, D., Thanos, D.-F., Lampoglou, G.-P., Pippa, Ν., Gatou, Μ.-A., Tremi, I., Papaspyropoulos, A., et al. (2023) · Antioxidants · doi:10.3390/antiox12010169 · Cited by 41 · see citing works
Autophagy and senescence: the molecular mechanisms and implications in liver diseases
Li, Q., Lin, Y., Liang, G., Xiao, N., Zhang, H., Yang, X., Yang, J., & Liu, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316880 · Cited by 43 · see citing works
“Autophagy can both activate and inhibit senescence [176].”
BackgroundConnecting chaperone-mediated autophagy dysfunction to cellular senescence
Moreno-Blas, D., Gorostieta-Salas, E., & Castro‐Obregón, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.11.001 · Cited by 42 · see citing works
Khalil, H., Maksoud, A. I. A. E., Alian, A., El-Hamady, W. A., Daif, A., Awad, A. M., & Guirgis, A. A. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1635619 · Cited by 42 · see citing works
“…cellular senescence and cell surface antigen presentation, protects against genome instability, and prevents necrosis, giving it a key role in preventing diseases such as cancer, neurodegeneration, cardiomyopathy, diabetes, liver and autoimmune diseases, and infections (Kang and Elledge, 2016).”
BackgroundCellular senescence in tissue repair: every cloud has a silver lining
Yun, M. H. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180081my · Cited by 42 · see citing works
“Expression of IL1a can activate the c/EBPb and NFkΒ pathways, which cooperatively regulate SASP components in various senescence contexts (Acosta et al., 2013, Kang et al., 2015, Kuilman et al., 2008), resulting in induction of the SASP.”
BackgroundAge-Related Lysosomal Dysfunctions
Guerrero‐Navarro, L., Jansen‐Dürr, P., & Cavinato, M. S. (2022) · Cells · doi:10.3390/cells11121977 · Cited by 42 · see citing works
“The selective induction of autophagy and the elimination of GATA4, a transcription factor that regulates senescence, may be beneficial for senescence reduction [37].”
BackgroundHelicobacter pylori ‐positive chronic atrophic gastritis and cellular senescence
Zheng, S., Zhu, L., Wu, L., Liu, H., Ma, X., Li, Q., Wu, M., Wang, W., Li, J., & Wu, H. (2022) · Helicobacter · doi:10.1111/hel.12944 · Cited by 40 · see citing works
Chen, F.-J., Liu, B., Wu, Q., Liu, J., Xu, Y., Zhou, S., & Shi, J. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.253310 · Cited by 41 · see citing works
“Autophagy thus plays a critical role in the prevention of neurodegenerative disorders, and dysfunction of autophagy affects cellular senescence and many other cellular signaling (Kang and Elledge, 2016).”
Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cells
Tingting, C., Yang, S., Zhang, S., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2351 · Cited by 40 · see citing works
Adenosine A2A receptor signaling promotes FoxO associated autophagy in chondrocytes
Friedman, B., Corciulo, C., Castro, C. M., & Cronstein, B. N. (2021) · Scientific Reports · doi:10.1038/s41598-020-80244-x · Cited by 41 · see citing works
Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy
Brockmueller, A., de Porras, V. R., & Shakibaei, M. (2024) · Phytotherapy Research · doi:10.1002/ptr.8220 · Cited by 43 · see citing works
“Through the connection via numerous commonly used signaling pathways, autophagy can be activated during senescence and can mediate it (Cassidy & Narita, 2022; Kang & Elledge, 2016; Young et al., 2009).”
Overexpression of Banana ATG8f Modulates Drought Stress Resistance in Arabidopsis
Li, B., Liu, G., Wang, Y., Wei, Y., & Shi, H. (2019) · Biomolecules · doi:10.3390/biom9120814 · Cited by 39 · see citing works
Sung, J. Y., Kim, S. G., Kim, J.-R., & Choi, H. C. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111394 · Cited by 38 · see citing works
Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?
Михайловна, Ж. Е., Lylova, E. S., Grigoreva, D. D., Игоревич, К. К., Osipova, A. V., Kulikov, E. P., Александрович, М. С., Belitsky, G. A., Budunova, I. V., Геннадиевна, Я. М., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179686 · Cited by 34 · see citing works
“It is tightly associated with autophagy and the intracellular degradation system indicated as the case for cellular senescence [82].”
BackgroundGuerrero‐Navarro, L., Jansen‐Dürr, P., & Cavinato, M. S. (2024) · Aging Cell · doi:10.1111/acel.14086 · Cited by 35 · see citing works
“Although the role of autophagy in senescence is debated (Kang & Elledge, 2016), autophagy has been shown to play an important role in the survival of senescent HDF generated by UVB irradiation (Cavinato et al., 2016).”
BackgroundLuo, L., Wu, J., Qiao, L., Lu, G., Li, J., & Li, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15313 · Cited by 33 · see citing works
Lin, J.-P., Brake, A., Donadieu, M., Lee, A., Smith, G., Hu, K., Nair, G., Kawaguchi, R., Sati, P., Geschwind, D. H., et al. (2025) · Science · doi:10.1126/science.adp6325 · Cited by 35 · see citing works
Cheng, P., Yu, F., Chen, S.-J., Feng, X. M., Jia, Z.-H., Hu, S., Cui, X.-L., Zhou, Y., Niu, Q., Liang, L., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123674 · Cited by 34 · see citing works
To target cellular senescence in diabetic kidney disease: the known and the unknown
Wei, Y., Mou, S., Yang, Q., Liu, F., Cooper, M. E., & Chai, Z. (2024) · Clinical Science · doi:10.1042/cs20240717 · Cited by 39 · see citing works
“Autophagy inhibition can either delay or promote cellular senescence, depending on cell type, senescence stimulus used, and the timing and duration of autophagy inhibition [101,102].”
BackgroundTan, M. L. M., Parkinson, E. K., Yap, L. F., & Paterson, I. C. (2021) · Scientific Reports · doi:10.1038/s41598-020-79789-8 · Cited by 35 · see citing works
Lin, Z., Miao, J., Zhang, T., He, M., Zhou, X.-N., Zhang, H., Gao, Y., & Bai, L. (2021) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2020.111199 · Cited by 35 · see citing works
Chen, H., Zhou, J., Chen, H., Liang, J., Xie, C., Gu, X., Wang, R., Mao, Z., Zhang, Y., Li, Q., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.574 · Cited by 33 · see citing works
RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression
Liu, X., Chen, J., Long, X., Lan, J., Liu, X., Zhou, M., Zhang, S., & Zhou, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04492-z · Cited by 33 · see citing works
Zhang, G., Chen, H., Deng, Y., Liu, M.-Q., Wu, Z., Ma, Z., He, X., Gao, Y., & Kang, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9181412 · Cited by 31 · see citing works
Is cellular senescence involved in cystic fibrosis?
Bezzerri, V., Piacenza, F., Caporelli, N., Malavolta, M., Provinciali, M., & Cipolli, M. (2019) · Respiratory Research · doi:10.1186/s12931-019-0993-2 · Cited by 30 · see citing works
Ma, T., Lv, L., Yu, Y., Jia, L., Song, X., Xu, X., Li, T., Sheng, X., Wang, H., Zhang, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.783506 · Cited by 28 · see citing works
Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis
Li, L., Li, J., Li, J., Zhou, H., Zhu, X., Zhang, P., Huang, B., Zhao, W.-T., Zhao, X., & Chen, E. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1472613 · Cited by 29 · see citing works
Coroglaucigenin induces senescence and autophagy in colorectal cancer cells
Huang, Y., Lei, J., Yi, G., Huang, F., Li, Y., Wang, C., Sun, Y., Dai, H., & Tan, G. (2018) · Cell Proliferation · doi:10.1111/cpr.12451 · Cited by 27 · see citing works
Li, T., Lu, H., Zhou, L., Jia, M., Zhang, L., Wu, H., Shan, L., & Efferth, T. (2021) · Cell Proliferation · doi:10.1111/cpr.13212 · Cited by 26 · see citing works
Novais, S. M., Bermejo-Millo, J. C., Loureiro, R., Mesquita, K. A., Domingues, M. R., Maciel, E. A., Melo, T., Baldeiras, I., Erickson, J. R., Holy, J. M., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1607694 · Cited by 27 · see citing works
DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology
Xiong, H., Hua, F., Dong, Y., Lin, Y., Ying, J., Liu, J., Wang, X., Zhang, L., & Zhang, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.933015 · Cited by 26 · see citing works
“However, its role in cell senescence is still under discussion (Kuilman et al., 2010; Gewirtz, 2013; Kang and Elledge, 2016).”
Backgroundc-Jun N-terminal kinase signaling in cellular senescence
Deng, Y., Adam, V., Nepovimová, E., Heger, Z., Valko, M., Wu, Q., Wei, W., & Kuča, K. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03540-1 · Cited by 28 · see citing works
“It exists in various physiological states of the 1 3 body and is closely related to cellular senescence (Kang and Elledge 2016; Ma et al.”
BackgroundCho, S., Hong, S. J., Kang, S. H., Park, Y., & Kim, S. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810981 · Cited by 27 · see citing works
“In the cisplatin group [30,31], p62 interacted with LC3, and its level decreased because of decomposition via the production of autophagosomes [32].”
BackgroundAdvances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy
Xiang, D., Zhou, L., Yang, R., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s448715 · Cited by 26 · see citing works
“52 (5) Pyroptosis is a newly discovered mode of programmed cell death, characterized by the continuous expansion of cells until cell membrane rupture, leading to the release of cell contents and then activating a strong inflammatory reaction.”
Background
- Authors
- Kang, C., & Elledge, S. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Elledge, Stephen J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2016-04-29
- Volume
- 12
- Issue
- 5
- Pages
- 898-899
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC4854549
- OpenAlex
- W2344541663
- Cited by
- 228
- References
- 0
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 37 · 2023: 22 · 2022: 33 · 2021: 33 · 2020: 25 · 2019: 21 · 2018: 13 · 2017: 9
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, selective autophagy, lysosomal degradation, senescence regulation
- MeSH terms
- Animals, Autophagy, DNA Damage, Humans, Lysosomes, Phenotype, Cellular Senescence, GATA4 Transcription Factor
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