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Cited by 43Autophagy in Disease and TherapyLiver physiology and pathologyTelomeres, Telomerase, and Senescence

Autophagy and senescence: the molecular mechanisms and implications in liver diseases

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Li, Qiao, Lin, Yan, Liang, Guangyu, Xiao, Nanyin, Zhang, Heng, Yang, Xiao, Yang, Jiankun, Liu, Anding·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms242316880PMC PMC10706096
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Abstract

The liver is the primary organ accountable for complex physiological functions, including lipid metabolism, toxic chemical degradation, bile acid synthesis, and glucose metabolism. Liver function homeostasis is essential for the stability of bodily functions and is involved in the complex regulation of the balance between cell proliferation and cell death. Cell proliferation-halting mechanisms, including autophagy and senescence, are implicated in the development of several liver diseases, such as cholestasis, viral hepatitis, nonalcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma. Among various cell death mechanisms, autophagy is a highly conserved and self-degradative cellular process that recycles damaged organelles, cellular debris, and proteins. This process also provides the substrate for further metabolism. A defect in the autophagy machinery can lead to premature diseases, accelerated aging, inflammatory state, tumorigenesis, and cellular senescence. Senescence, another cell death type, is an active player in eliminating premalignant cells. At the same time, senescent cells can affect the function of neighboring cells by secreting the senescence-associated secretory phenotype and induce paracrine senescence. Autophagy can promote and delay cellular senescence under different contexts. This review decodes the roles of autophagy and senescence in multiple liver diseases to achieve a better understanding of the regulatory mechanisms and implications of autophagy and senescence in various liver diseases.

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Cited by

Sorted by citations

Authors
Li, Q., Lin, Y., Liang, G., Xiao, N., Zhang, H., Yang, X., Yang, J., & Liu, A.
Affiliations
  • Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430100, China
  • Tongji Hospital (CN)
Corresponding author
Liu, Anding
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-11-28
Volume
24
Issue
23
Pages
16880
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms242316880
PMC
PMC10706096
OpenAlex
W4389080766
Cited by
43
References
26
Citations by year
2026: 10 · 2025: 19 · 2024: 14
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
the National Natural Science Fund of China (NSFC) (82071590, 82271596)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
autophagy, cellular senescence, liver disease, senescence-associated secretory phenotype, paracrine senescence, hepatocellular carcinoma, non-alcoholic fatty liver disease, liver fibrosis, cholestasis, viral hepatitis, cell death, liver homeostasis
MeSH terms
Aging, Autophagy, Humans, Cellular Senescence, Non-alcoholic Fatty Liver Disease

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