Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging
Open accessAbstract
Regeneration of skeletal muscle relies on its resident stem cells, also known as satellite cells, which are normally quiescent. With aging, satellite cell quiescence is lost concomitant with a muscle regenerative decline. Here we demonstrate that autophagy sustains quiescence over time and that its failure with age drives senescence, which accounts for stem cell loss of function. Pharmacological and genetic reestablishment of autophagy restores homeostasis and regenerative functions in geriatric satellite cells, which has relevance for the elderly population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The decreased activity of myogenic regulatory factors is due to dysregulated autophagy concerning inflammation and insulin resistance, also leading to a reduction in satellite cells.
“The decreased activity of MRF is due to dysregulated autophagy concerning inflammation and IR, also leading to a reduction in satellite cells [92, 116, 126, 127].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [126]
Satellite cells in obesity and overweight have a minor expression and activity of myogenic regulatory factors such as MyoD, Myf5, and Myf6.
“Furthermore, satellite cells in obesity and overweight have a minor expression and activity of myogenic regulatory factors (MRFs) such as MyoD, Myf5, and Myf6.”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Still being checked.
Cited by
Sorted by citations
NAD+ metabolism, stemness, the immune response, and cancer
Navas, L. E., & Carnero, A. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00354-w · Cited by 529 · see citing works
The quest to slow ageing through drug discovery
Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works
Doblado, L., Lueck, C., Rey, C., Samhan-Arias, A. K., Priéto, I., Stacchiotti, A., & Monsalve, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083903 · Cited by 229 · see citing works
A Futile Battle? Protein Quality Control and the Stress of Aging
Higuchi‐Sanabria, R., Frankino, P. A., Paul, J. W., Tronnes, S. U., & Dillin, A. G. (2018) · Developmental Cell · doi:10.1016/j.devcel.2017.12.020 · Cited by 149 · see citing works
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy
Lang, A., Anand, R., Altinoluk-Hambüchen, S., Ezzahoini, H., Stefanski, A., Iram, A., Bergmann, L., Urbach, J., Böhler, P., Hänsel, J., et al. (2017) · Aging · doi:10.18632/aging.101307 · Cited by 145 · see citing works
Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease
Xia, M., Xie, X., Ding, J., Du, R., & Hu, G. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01791-8 · Cited by 138 · see citing works
Pleiotropic Effects of mTOR and Autophagy During Development and Aging
Schmeißer, K., & Parker, J. A. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00192 · Cited by 117 · see citing works
Satellite cells in ageing: use it or lose it
Chen, W., Datzkiw, D., & Rudnicki, M. A. (2020) · Open Biology · doi:10.1098/rsob.200048 · Cited by 116 · see citing works
Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia
Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., Lezza, A. M. S., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Biological Chemistry · doi:10.1515/hsz-2017-0331 · Cited by 116 · see citing works
Muñoz‐Cánoves, P., Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15182 · Cited by 111 · see citing works
Self-citationMoorefield, E., Andres, S. F., Blue, R. E., Landeghem, L. V., Mah, A. T., Santoro, M. A., & Ding, S. (2017) · Aging · doi:10.18632/aging.101279 · Cited by 110 · see citing works
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104 · see citing works
The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells
Sbrana, F. V., Cortini, M., Avnet, S., Perut, F., Columbaro, M., Milito, A. D., & Baldini, N. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9690-4 · Cited by 103 · see citing works
Rong, S., Wang, L., Peng, Z., Liao, Y., Li, D., Yang, X., Nussler, A. K., Liu, L., Bao, W., & Yang, W. Q. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12536 · Cited by 104 · see citing works
The critical role of oxidative stress in sarcopenic obesity
Gonzalez, A., Simon, F., Achiardi, O., Vilos, C., Cabrera, D., & Cabello-Verrugio, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4493817 · Cited by 79 · see citing works
Hassanpour, M., Rezabakhsh, A., Pezeshkian, M., Rahbarghazi, R., & Nouri, M. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1060-5 · Cited by 80 · see citing works
Overweight in elderly people induces impaired autophagy in skeletal muscle
Potes, Y., de Luxán-Delgado, B., Rodriguez-González, S., Guimarães, M. R. M., Solano, J. J., Fernández-Fernández, M., Bermúdez, M., Boga, J. A., Vega-Naredo, I., & Coto-Montes, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.018 · Cited by 67 · see citing works
Tumor-derived cytokines impair myogenesis and alter the skeletal muscle immune microenvironment
Hogan, K. A., Cho, D. S., Arneson‐Wissink, P. C., Samani, A., Palines, P. A., Yang, Y., & Doles, J. D. (2017) · Cytokine · doi:10.1016/j.cyto.2017.11.006 · Cited by 57 · see citing works
Stem Cell Aging in Lifespan and Disease: A State-of-the-Art Review
Sameri, S., Samadi, P., Dehghan, R., Salem, E., Hosseini, N. F., & Amini, R. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200213105155 · Cited by 55 · see citing works
Molecular Insights into Muscle Homeostasis, Atrophy and Wasting
Scicchitano, B. M., Dobrowolny, G., Sica, G., & Musarò, A. (2018) · Current Genomics · doi:10.2174/1389202919666180101153911 · Cited by 50 · see citing works
The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells
McKay, L. K., & White, J. P. (2021) · Cells · doi:10.3390/cells10061430 · Cited by 36 · see citing works
Sharma, M., Hunter, K. D., Fonseca, F. P., & Radhakrishnan, R. A. (2021) · Head & Neck · doi:10.1002/hed.26805 · Cited by 36 · see citing works
Intimate Relations—Mitochondria and Ageing
Webb, M., & Sideris, D. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207580 · Cited by 36 · see citing works
Aging, metabolism and stem cells: Spotlight on muscle stem cells
García-Prat, L., & Muñoz-Cánoves, P. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.021 · Cited by 34 · see citing works
Self-citationGoljanek‐Whysall, K., Iwanejko, L., Vasilaki, A., Pekovic‐Vaughan, V., & McDonagh, B. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9643-x · Cited by 31 · see citing works
Marzetti, E., Lozanoska‐Ochser, B., Calvani, R., Landi, F., Coelho‐Júnior, H. J., & Picca, A. (2024) · Biomolecules · doi:10.3390/biom14040415 · Cited by 33 · see citing works
Autophagy, Aging, and Longevity
Luo, L., & Qin, Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0602-4_24 · Cited by 33 · see citing works
Altered myogenesis and premature senescence underlie human TRIM32-related myopathy
Servián‐Morilla, E., Cabrera‐Serrano, M., Rivas, E., Carvajal, A., Lamont, P. J., Pelayo‐Negro, A. L., Ravenscroft, G., Junckerstorff, R. C., Dyke, J. M., Fletcher, S., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0683-9 · Cited by 32 · see citing works
Picca, A., Lozanoska‐Ochser, B., Calvani, R., Coelho‐Júnior, H. J., Leewenburgh, C., & Marzetti, E. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112204 · Cited by 30 · see citing works
Skeletal muscle aging – Stem cells in the spotlight
Henze, H., Jung, M. J., Ahrens, H. E., Steiner, S., & von Maltzahn, J. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111283 · Cited by 28 · see citing works
Li, B., Hu, X., Yang, Y., Zhu, M., Zhang, J., Wang, Y., Pei, X., Zhou, H., & Wu, J. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.06.012 · Cited by 28 · see citing works
Bi, S., Wang, H., & Kuang, W. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.005 · Cited by 27 · see citing works
Deaccelerated Myogenesis and Autophagy in Genetically Induced Pulmonary Emphysema
Balnis, J., Drake, L. A., Singer, D. V., Vincent, C. E., Korponay, T. C., D’Armiento, J., Lee, C. G., Elias, J. A., Singer, H. A., & Jaitovich, A. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0351oc · Cited by 27 · see citing works
Aging, Osteo-Sarcopenia, and Musculoskeletal Mechano-Transduction
Leser, J. M., Harriot, A. D., Buck, H., Ward, C. W., & Stains, J. P. (2021) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2021.782848 · Cited by 27 · see citing works
Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle
Wang, K., Gan, M., Lei, Y., Liao, T., Li, J., Niu, L., Zhao, Y., Chen, L., Wang, Y., Zhu, L., et al. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00771-1 · Cited by 33 · see citing works
Decline of regenerative potential of old muscle stem cells: contribution to muscle aging
Sahinyan, K., Lazure, F., Blackburn, D. M., & Soleimani, V. D. (2022) · FEBS Journal · doi:10.1111/febs.16352 · Cited by 25 · see citing works
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells
Nguyen-McCarty, M., & Klein, P. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177054 · Cited by 23 · see citing works
New mechanisms driving muscle stem cell regenerative decline with aging
Sousa‐Victor, P., García‐Prat, L., & Muñoz‐Cánoves, P. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180041pm · Cited by 22 · see citing works
Self-citationAutophagy in adult stem cell homeostasis, aging, and disease therapy
Zhao, K., Chan, I. T. C., Tse, E. H. Y., Xie, Z., Cheung, T. H., & Zeng, Y. A. (2025) · Cell Regeneration · doi:10.1186/s13619-025-00224-2 · Cited by 22 · see citing works
Programmed cell death and tissue regeneration: a link that should be resolved
Kopeina, G. S., Efimenko, A. Y., Va, T., & Zhivotovsky, B. (2025) · Physiological Reviews · doi:10.1152/physrev.00036.2024 · Cited by 20 · see citing works
NAD+: An old but promising therapeutic agent for skeletal muscle ageing
Xu, Y., & Xiao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102106 · Cited by 19 · see citing works
Adult Muscle Stem Cells: Exploring the Links Between Systemic and Cellular Metabolism
Purohit, G., & Dhawan, J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00312 · Cited by 17 · see citing works
Rani, L., Sahu, M. R., & Mondal, A. C. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.07.007 · Cited by 16 · see citing works
Autophagy in Muscle Regeneration: Mechanisms, Targets, and Therapeutic Perspective
Chu, Y., Yuan, X., Tao, Y., Yang, B. T., & Luo, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211901 · Cited by 16 · see citing works
Tao, H., Liu, Q., Zeng, A., & Song, L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110497 · Cited by 13 · see citing works
Kamal, M. J., Joanisse, S., & Parise, G. (2023) · GeroScience · doi:10.1007/s11357-023-00929-9 · Cited by 12 · see citing works
Rapamycin improves satellite cells’ autophagy and muscle regeneration during hypercapnia
Balnis, J., Jackson, E. L., Drake, L. A., Singer, D. V., Ramos, R. B., Singer, H. A., & Jaitovich, A. (2024) · JCI Insight · doi:10.1172/jci.insight.182842 · Cited by 10 · see citing works
“Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?
Mietsch, M., & Hinkel, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041824 · Cited by 9 · see citing works
Shaikh, S., Ahmad, K., Lim, J. H., Ahmad, S. S., Lee, E. J., & Choi, I. (2025) · Pharmaceuticals · doi:10.3390/ph18091407 · Cited by 6 · see citing works
Effects of Focused Vibrations on Human Satellite Cells
Sancilio, S., Nobilio, S., Ruggiero, A., Filippo, E. S. D., Stati, G., Fulle, S., Bellomo, R. G., Saggini, R., & Pietro, R. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116026 · Cited by 6 · see citing works
The Interactome in the Evolution From Frailty to Sarcopenic Dependence
Coto‐Montes, A. M., González‐Blanco, L., Antuña, E., Menéndez‐Valle, I., Bermejo-Millo, J. C., Caballero, B., Vega‐Naredo, I., & Potes, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.792825 · Cited by 6 · see citing works
The impact of cellular senescence on aging skeletal muscle
Kamal, M. J., Bevington, R. T., Johnson, A., & Parise, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1719279 · Cited by 5 · see citing works
Characterization of Proteome Changes in Aged and Collagen VI-Deficient Human Pericyte Cultures
Moriggi, M., Torretta, E., Cescon, M., Russo, L., Gregorio, I. D., Braghetta, P., Sabatelli, P., Faldini, C., Merlini, L., Gargioli, C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137118 · Cited by 5 · see citing works
Autophagy reprogramming stem cell pluripotency and multiple-lineage differentiation
Yang, Y., Lai, W., Lin, T.-W., Lin, Y., Chien, Y., Tsai, Y., Tai, H., Wang, C.-L., Liu, Y.-Y., Huang, P., et al. (2022) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000728 · Cited by 4 · see citing works
Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation
Yeh, D.-C., & Chan, T.-M. (2018) · Stem Cell Discovery · doi:10.4236/scd.2018.82002 · Cited by 3 · see citing works
Sarcopenia: Pathophysiology and Treatment Strategies
Qiu, C., Yang, X., & Yu, P. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230518105408 · Cited by 3 · see citing works
The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
Aktas, B. H., Upcin, B., Henke, E., Padmasekar, M., Qin, X., & Ergün, S. (2019) · Stem Cells International · doi:10.1155/2019/1608787 · Cited by 2 · see citing works
Rinnerthaler, M., & Richter, K. (2018) · InTech eBooks · doi:10.5772/intechopen.76246 · Cited by 2 · see citing works
Linking mitochondrial dysfunction to sarcopenia
Alway, S. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00004-1 · Cited by 1 · see citing works
Novel strategies to overcome drug resistance in liver cancer
Wang, Y. (2018) · Figshare · Cited by 1 · see citing works
Caspase-3 is involved in nuclear remodeling of human satellite cells under stress conditionsPreprint
Sancilio, S., Pietro, R. D., Mancinelli, R., Impicciatore, G. G., Stati, G., & Fulle, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4247887/v1 · Cited by 1 · see citing works
Autophagy, Exercise, and Lifestyle Modification
CAMERA, D. M., & Smiles, W. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00025-0
Dysregulated myogenesis and autophagy in genetically induced pulmonary emphysemaPreprint
Balnis, J., Drake, L. A., Singer, D. V., Vincent, C. E., Korponay, T. C., D'Armiento, J. M., Lee, C. G., Elias, J. A., Singer, H. A., & Jaitovich, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.08.450201
Long-term DNA methylation changes induced by age and elevated CO2 in skeletal muscle
Balnis, J., Madrid, A., Jackson, E. L., Drake, L. A., Vincent, C. E., Singer, H. A., Alisch, R. S., & Jaitovich, A. (2025) · Skeletal Muscle · doi:10.1186/s13395-025-00406-1
Xia, M.-L., Xie, X.-H., Ding, J.-H., Du, R.-H., & Hu, G. (2020) · Figshare · doi:10.6084/m9.figshare.12097050
An H4K20me3-CTCF switch at stable TAD boundaries enforces reversible cell state transitionsPreprint
Atai, K., Mitra, M., Bohn, E., Hu, R., Corvalan, A. Z., Jelínek, D., Voisin, L., Ambrus, A., Sarathy, K., Sparks, W. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.29.702647
Superenhancer-mediated ferroptosis in age-related hearing loss: cochlear epigenomics
Zhang, C., Yang, T., Luo, X., Fu, X., Sun, Y., & Yuan, W. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06117-0
Non-apoptotic role of caspase enzymes in satellite cells from human skeletal muscle
Pietro, R. D., Mancinelli, R., Impicciatore, G. G., Stati, G., Fulle, S., & Sancilio, S. (2026) · Biogerontology · doi:10.1007/s10522-026-10478-1
- Authors
- García-Prat, L., Muñoz-Cánoves, P., & Martinez-Vicente, M.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2016-02-18
- Volume
- 12
- Issue
- 3
- Pages
- 612-613
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC4835950
- OpenAlex
- W2322179929
- Cited by
- 70
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 5 · 2016: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- satellite cells, muscle stem cells, aging, stem cell quiescence, cellular senescence, skeletal muscle regeneration, stem cell dysfunction
- MeSH terms
- Aging, Animals, Autophagy, Models, Biological, Regeneration, Stem Cells, Reactive Oxygen Species, Muscle, Skeletal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
