Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
Open accessAbstract
Aging of an organism is associated with the functional decline of tissues and organs, as well as a sharp decline in the regenerative capacity of stem cells. A prevailing view holds that the aging rate of an individual depends on the ratio of tissue attrition to tissue regeneration. Therefore, manipulations that favor the balance towards regeneration may prevent or delay aging. Skeletal muscle is a specialized tissue composed of postmitotic myofibers that contract to generate force. Satellite cells are the adult stem cells responsible for skeletal muscle regeneration. Recent studies on the biology of skeletal muscle and satellite cells in aging have uncovered the critical impact of systemic and niche factors on stem cell functionality and demonstrated the capacity of aged satellite cells to rejuvenate and increase their regenerative potential when exposed to a youthful environment. Here we review the current literature on the coordinated relationship between cell extrinsic and intrinsic factors that regulate the function of satellite cells, and ultimately determine tissue homeostasis and repair during aging, and which encourage the search for new anti‐aging strategies.
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MuSC numbers remain largely stable until a geriatric age beyond 26 months.
“Indeed MuSC numbers do not decrease appreciably until a highly advanced ‘geriatric’ age (>26 months) as determined by scoring of MuSCs in their anatomically defined niche in muscle tissue sections52,53.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [53]
Sarcopenia is associated with increased apoptosis and reduced muscle regeneration, leading to muscle wasting.
“Sarcopenia, is associated with increased levels of apoptosis (47) and reduced capabilities for muscle regeneration (41) leading to muscle wasting.”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [41]
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“INTRODUCTION Sarcopenia is associated with increased levels of apoptosis (47) and reduced capabilities for muscle regeneration (41) leading to muscle wasting.”
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New mechanisms driving muscle stem cell regenerative decline with aging
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- Authors
- García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Muñoz‐Cánoves, Pura
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2013-03-21
- Volume
- 280
- Issue
- 17
- Pages
- 4051-4062
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1977898454
- Cited by
- 152
- References
- 124
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 17 · 2014: 15 · 2013: 3
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación (PLE2009)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- aging, skeletal muscle stem cells, satellite cells, tissue regeneration, regenerative capacity, stem cell niche, external factors, intrinsic factor, tissue homeostasis, anti-aging strategies, rejuvenation
- MeSH terms
- Aging, Animals, Cell Differentiation, Humans, Stem Cells, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle
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