The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911 · see citing works

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

Pagano, M., Tam, S. W., Theodoras, A. M., Beer‐Romero, P., Sal, G. D., Chau, V., Yew, P. R., Draetta, G. F., & Rolfe, M. (1995) · Science · doi:10.1126/science.7624798 · Cited by 1,815 · see citing works

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Carrano, A. C., Eytan, E., Hershko, A., & Pagano, M. (1999) · Nature Cell Biology · doi:10.1038/12013 · Cited by 1,544 · see citing works

Autophagy maintains stemness by preventing senescence

García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355 · see citing works

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,211 · see citing works

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00220-x · Cited by 1,043 · see citing works

Satellite cells as the source of nuclei in muscles of growing rats

Moss, F. P., & Leblond, C. P. (1971) · The Anatomical Record · doi:10.1002/ar.1091700405 · Cited by 1,025 · see citing works

Geriatric muscle stem cells switch reversible quiescence into senescence

Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010 · see citing works

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Liang, J., Zubovitz, J., Petrocelli, T., Kotchetkov, R., Connor, M. K., Han, K. C.-Z., Lee, J.-H., Ciarallo, S., Catzavelos, C., Beniston, R., et al. (2002) · Nature Medicine · doi:10.1038/nm761 · Cited by 947 · see citing works

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924 · see citing works

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B. T., Ding, Z., Larrea, M. D., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1537 · Cited by 868 · see citing works

AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860 · see citing works

The aged niche disrupts muscle stem cell quiescence

Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851 · see citing works

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824 · see citing works

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., et al. (2014) · Nature · doi:10.1038/nature13255 · Cited by 776 · see citing works

Pax7 is critical for the normal function of satellite cells in adult skeletal muscle

von Maltzahn, J., Jones, A. E., Parks, R. J., & Rudnicki, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307680110 · Cited by 602 · see citing works

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formationPreprint

Montagnoli, A., FIORE, F., Eytan, E., Carrano, A. C., Draetta, G. F., Hershko, A., & Pagano, M. (1999) · Genes & Development · doi:10.1101/gad.13.9.1181 · Cited by 596 · see citing works

Autophagy: The spotlight for cellular stress responses

Ravanan, P., Florance, I., & Talwar, P. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.029 · Cited by 578 · see citing works

The central role of muscle stem cells in regenerative failure with aging

Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437 · see citing works

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

Fry, C. S., Lee, J. D., Mula, J., Kirby, T. J., Jackson, J. R., Liu, F., Yang, L., Mendias, C. L., Dupont-Versteegden, E. E., McCarthy, J. J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3710 · Cited by 432 · see citing works

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

Cerletti, M., Jang, Y. C., Finley, L. W. S., Haigis, M. C., & Wagers, A. J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.002 · Cited by 397 · see citing works

A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging

Collins, C. A., Zammit, P. S., Ruiz, A. P., Morgan, J. E., & Partridge, T. A. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0372 · Cited by 320 · see citing works

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

Tang, A. H., & Rando, T. A. (2014) · The EMBO Journal · doi:10.15252/embj.201488278 · Cited by 294 · see citing works

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

Hong, F., Larrea, M. D., Doughty, C. A., Kwiatkowski, D. J., Squillace, R. M., & Slingerland, J. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.027 · Cited by 252 · see citing works

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle

White, J. P., Gao, S., Puppa, M., Sato, S., Welle, S. L., & Carson, J. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.019 · Cited by 250 · see citing works

AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway

Sanli, T., Steinberg, G. R., Singh, G., & Tsakiridis, T. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.26726 · Cited by 220 · see citing works

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27Kip1

Hiromura, K., Pippin, J. W., Fero, M. L., Roberts, J. M., & Shankland, S. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5461 · Cited by 212 · see citing works

Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise

Shefer, G., Rauner, G., Yablonka‐Reuveni, Z., & Benayahu, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013307 · Cited by 211 · see citing works

A link between cell cycle and cell death: Bax and Bcl‐2 modulate Cdk2 activation during thymocyte apoptosis

Gil‐Gómez, G., Berns, A. J. M., & Brady, H. J. M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7209 · Cited by 183 · see citing works

Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state

Chakkalakal, J. V., Christensen, J., Xiang, W., Tierney, M. T., Boscolo, F. S., Sacco, A., & Brack, A. S. (2014) · Development · doi:10.1242/dev.100842 · Cited by 148 · see citing works

Regenerative decline of stem cells in sarcopenia

Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147 · see citing works

AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis

Théret, M., Gsaier, L., Schaffer, B. E., Juban, G., Larbi, S. B., Weiss‐Gayet, M., Bultot, L., Collodet, C., Foretz, M., Dominique Desplanches, C., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695273 · Cited by 138 · see citing works

Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis

Jejurikar, S. S., Henkelman, E., Cederna, P. S., Marcelo, C. L., Urbanchek, M. G., & Kuzon, W. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.053 · Cited by 133 · see citing works

Reduction of Cytosolic p27Kip1 Inhibits Cancer Cell Motility, Survival, and Tumorigenicity

Wu, F. Y., Wang, S. E., Sanders, M. E., Shin, I., Rojo, F., Baselga, J. M., & Arteaga, C. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3304 · Cited by 130 · see citing works

Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative FunctionPreprint

Jang, Y. C., Sinha, M., Cerletti, M., Dall’Osso, C., & Wagers, A. J. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010652 · Cited by 127 · see citing works

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, J. P., Wrann, C. D., Rao, R. R., Nair, S. K., Jedrychowski, M. P., You, J.-S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417898111 · Cited by 123 · see citing works

Complex Regulation of the Cyclin-Dependent Kinase Inhibitor p27kip1 in Thyroid Cancer Cells by the PI3K/AKT Pathway

Motti, M. L., Califano, D., Troncone, G., Marco, C. D., Migliaccio, I., Palmieri, E. A., Pezzullo, L., Palombini, L., Fusco, A., & Viglietto, G. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62295-x · Cited by 98 · see citing works

Human and Mouse Skeletal Muscle Stem Cells: Convergent and Divergent Mechanisms of Myogenesis

Bareja, A., Holt, J. A., Luo, G., Chang, C. K. W., Lin, J., Hinken, A. C., Freudenberg, J., Kraus, W. E., Evans, W. J., & Billin, A. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090398 · Cited by 96 · see citing works

AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration

Fu, X., Zhu, M. J., Dodson, M. V., & Du, ‬. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.665232 · Cited by 96 · see citing works

Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals

Machida, S., & Booth, F. W. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.009 · Cited by 87 · see citing works

Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging

García-Prat, L., Muñoz-Cánoves, P., & Martinez-Vicente, M. (2016) · Autophagy · doi:10.1080/15548627.2016.1143211 · Cited by 70 · see citing works

Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury.

White, J., Baltgalvis, K. A., Sato, S., Wilson, L., & Carson, J. A. (2009) · Journal of applied physiology · doi:10.1152/japplphysiol.00668.2009 · Cited by 62 · see citing works

Aging Changes in Satellite Cells and Their Functions

Hikida, R. S. (2011) · Current Aging Science · doi:10.2174/1874609811104030279 · Cited by 54 · see citing works

Immuno-Analysis and FACS Sorting of Adult Muscle Fiber-Associated Stem/Precursor Cells

Conboy, M. J., Cerletti, M., Wagers, A. J., & Conboy, I. M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-063-2_11 · Cited by 52 · see citing works

FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell‐cycle progression

Rathbone, C. R., Booth, F. W., & Lees, S. J. (2007) · Muscle & Nerve · doi:10.1002/mus.20897 · Cited by 47 · see citing works

Dual role of the caspase enzymes in satellite cells from aged and young subjects

Fulle, S., Sancilio, S., Mancinelli, R., Gatta, V., & Pietro, R. D. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.472 · Cited by 46 · see citing works

Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats

Krajnak, K., Waugh, S., Miller, R., Baker, B. A., Geronilla, K. B., Alway, S. E., & Cutlip, R. G. (2006) · Muscle & Nerve · doi:10.1002/mus.20656 · Cited by 46 · see citing works

p27 Protein Protects Metabolically Stressed Cardiomyocytes from Apoptosis by Promoting Autophagy

Sun, X., Momen, A., Wu, J., Noyan, H., Li, R., von Harsdorf, R., & Husain, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.542795 · Cited by 44 · see citing works

Interplay between autophagy and programmed cell death in mammalian neural stem cells

Chung, K. M., & Yu, S.-W. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.8.164 · Cited by 30 · see citing works

No change in skeletal muscle satellite cells in young and aging rat soleus muscle

Brooks, N. E., Schuenke, M. D., & Hikida, R. S. (2009) · The Journal of Physiological Sciences · doi:10.1007/s12576-009-0058-2 · Cited by 27 · see citing works

Editorial: Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Merlini, L., Bonaldo, P., & Marzetti, E. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00153 · Cited by 12 · see citing works

Biological Functions of Autophagy Genes: A Disease Perspective

Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832 · see citing works

Control of satellite cell function in muscle regeneration and its disruption in ageing

Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works

The landscape of aging

Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works

Perspectives on skeletal muscle stem cells

Relaix, F., Bencze, M., Borok, M. J., Vartanian, A. D., Gattazzo, F., Mademtzoglou, D., Perez-Diaz, S., Prola, A., Fernandez, P. C. R., Rotini, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20760-6 · Cited by 389 · see citing works

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

Hong, X., Isern, J., Campanario, S., Perdiguero, E., Ramírez-Pardo, I., Segalés, J., Hernansanz-Agustín, P., Curtabbi, A., Deryagin, O., Pollán, A., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.009 · Cited by 213 · see citing works

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism

Baht, G., Bareja, A., Lee, D. E., Rao, R. R., Huang, R., Huebner, J., Bartlett, D. B., Hart, C., Gibson, J. R., Lanza, I., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0184-y · Cited by 168 · see citing works

Divergent Roles of Inflammation in Skeletal Muscle Recovery From Injury

Howard, E. E., Pasiakos, S. M., Blesso, C. N., Fussell, M. A., & Rodriguez, N. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00087 · Cited by 176 · see citing works

Stem Cell Aging in Skeletal Muscle Regeneration and Disease

Yamakawa, H., Kusumoto, D., Hashimoto, H., & Yuasa, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051830 · Cited by 178 · see citing works

p27 as a Transcriptional Regulator: New Roles in Development and Cancer

Razavipour, S. F., Harikumar, K. B., & Slingerland, J. M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3663 · Cited by 152 · see citing works

p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth

Nowosad, A., Jeannot, P., Callot, C., Creff, J., Perchey, R. T., Joffre, C., Codogno, P., Manenti, S., & Besson, A. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0554-4 · Cited by 144 · see citing works

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00451-9 · Cited by 134 · see citing works

p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation

Nowosad, A., Creff, J., Jeannot, P., Culerrier, R. M., Codogno, P., Manenti, S., Nguyen, L., & Besson, A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03759-9 · Cited by 125 · see citing works

Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

Muñoz‐Cánoves, P., Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15182 · Cited by 111 · see citing works

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Yu, M., Zhang, H., Wang, B. Z., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021) · Cells · doi:10.3390/cells10030660 · Cited by 114 · see citing works

Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin‐Deficient mdx Mice

Sebori, R., Kuno, A., Hosoda, R., Hayashi, T., & Horio, Y. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9179270 · Cited by 113 · see citing works

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Rong, S., Wang, L., Peng, Z., Liao, Y., Li, D., Yang, X., Nussler, A. K., Liu, L., Bao, W., & Yang, W. Q. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12536 · Cited by 104 · see citing works

Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Zhuang, Y., Jiang, S., Deng, X., Lao, A., Hua, X., Xie, Y., Jiang, L., Wang, X., & Lin, K. (2024) · Science Advances · doi:10.1126/sciadv.adl0372 · Cited by 91 · see citing works

Autophagy in muscle regeneration: potential therapies for myopathies

Chen, W., Chen, Y., Liu, Y., & Wang, X. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13000 · Cited by 77 · see citing works

Contribution of muscle satellite cells to sarcopenia

Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74 · see citing works

A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation

Miao, Z., Adkins-Threats, M., Burclaff, J., Osaki, L. H., Sun, J.-X., Kefalov, Y., He, Z., Wang, Z.-N., & Mills, J. C. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.03.006 · Cited by 68 · see citing works

Stem cell aging in the skeletal muscle: The importance of communication

Hong, X., Campanario, S., Ramírez‐Pardo, I., Grima-Terrén, M., Isern, J., & Muñoz‐Cánoves, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101528 · Cited by 69 · see citing works

Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

Lee, D. E., Bareja, A., Bartlett, D. B., & White, J. P. (2019) · Cells · doi:10.3390/cells8020183 · Cited by 64 · see citing works

Autophagy in sarcopenia: Possible mechanisms and novel therapies

Xie, G., Jin, H., Mikhail, H., Pavel, V., Yang, G., Ji, B., Lu, B., & Li, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115147 · Cited by 57 · see citing works

Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling

Lee, D. E., McKay, L. K., Bareja, A., Li, Y., Khodabukus, A., Bursac, N., Taylor, G. A., Baht, G. S., & White, J. P. (2022) · Nature Communications · doi:10.1038/s41467-022-35390-3 · Cited by 52 · see citing works

Pathogenesis of Hepatocellular Carcinoma: The Interplay of Apoptosis and Autophagy

Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2023) · Biomedicines · doi:10.3390/biomedicines11041166 · Cited by 47 · see citing works

Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer

Ganesan, T., Sinniah, A., Chik, Z., & Alshawsh, M. A. (2020) · Nutrients · doi:10.3390/nu12082430 · Cited by 40 · see citing works

p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties

Bencivenga, D., Stampone, E., Roberti, D., Ragione, F. D., & Borriello, A. (2021) · Cells · doi:10.3390/cells10092254 · Cited by 37 · see citing works

The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells

McKay, L. K., & White, J. P. (2021) · Cells · doi:10.3390/cells10061430 · Cited by 36 · see citing works

p27, The Cell Cycle and Alzheimer´s Disease

García‐Osta, A., Dong, J., Moreno-Aliaga, M. J., & Ramírez, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031211 · Cited by 34 · see citing works

Regulatory role of exercise-induced autophagy for sarcopenia

Liang, J., Zeng, Z., Zhang, Y., & Chen, N. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2019.110789 · Cited by 33 · see citing works

The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer

Ziegler, D. V., Huber, K., & Lluis Fajas, A. (2021) · Cancers · doi:10.3390/cancers14010153 · Cited by 33 · see citing works

A carotenoid-enriched extract from pumpkin delays cell proliferation in a human chronic lymphocytic leukemia cell line through the modulation of autophagic flux

Moccia, S., Russo, M., Durante, M., Lenucci, M. S., Mita, G., & Russo, G. L. (2020) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2020.05.001 · Cited by 30 · see citing works

From cyclins to CDKIs: Cell cycle regulation of skeletal muscle stem cell quiescence and activation

Mademtzoglou, D., & Relaix, F. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113275 · Cited by 32 · see citing works

Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice

Li, F., Zhang, F., Shi, H., Xia, H., Wei, X., Liu, S., Wu, T., Li, Y., Feng, S., Chen, M., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13526 · Cited by 27 · see citing works

Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy

Kobayashi, Y., Tanaka, T. N., Mulati, M., Ochi, H., Sato, S., Kaldis, P., Yoshii, T., Okawa, A., & Inose, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.564581 · Cited by 28 · see citing works

A cancer‐associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss‐of‐function

Bencivenga, D., Stampone, E., Aulitto, A., Tramontano, A., Barone, C., Negri, A., Roberti, D., Perrotta, S., Ragione, F. D., & Borriello, A. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12881 · Cited by 27 · see citing works

The Regulation of the AMPK/mTOR Axis Mitigates Tendon Stem/Progenitor Cell Senescence and Delays Tendon Aging

Dai, G.-C., Li, Y., Zhang, M., Lu, P., Zhang, Y., Wang, H., Shi, L., Cao, M., Shen, R., & Rui, Y. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10526-0 · Cited by 27 · see citing works

Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo

Arjona, M., Goshayeshi, A., Rodríguez-Mateo, C., Brett, J. O., Both, P., Ishak, H. D., & Rando, T. A. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.012 · Cited by 25 · see citing works

Autophagy in adult stem cell homeostasis, aging, and disease therapy

Zhao, K., Chan, I. T. C., Tse, E. H. Y., Xie, Z., Cheung, T. H., & Zeng, Y. A. (2025) · Cell Regeneration · doi:10.1186/s13619-025-00224-2 · Cited by 22 · see citing works

Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge

Galasso, L., Cappella, A., Mulè, A., Castelli, L., Ciorciari, A. M., Stacchiotti, A., & Montaruli, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129798 · Cited by 23 · see citing works

Programmed cell death and tissue regeneration: a link that should be resolved

Kopeina, G. S., Efimenko, A. Y., Va, T., & Zhivotovsky, B. (2025) · Physiological Reviews · doi:10.1152/physrev.00036.2024 · Cited by 20 · see citing works

NAD+: An old but promising therapeutic agent for skeletal muscle ageing

Xu, Y., & Xiao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102106 · Cited by 19 · see citing works

Transcriptional regulation of autophagy in skeletal muscle stem cells

Krishnan, P. D. G., Lee, W. X., Goh, K. Y., Choy, S. M., Turqueza, L. R. R., Lim, Z. H., & Tang, H.-W. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052007 · Cited by 19 · see citing works

Regulation of p27Kip1 and p57Kip2 Functions by Natural Polyphenols

Russo, G. L., Stampone, E., Cervellera, C., & Borriello, A. (2020) · Biomolecules · doi:10.3390/biom10091316 · Cited by 17 · see citing works

Autophagy and polyphenol intervention strategy in aging

Gu, Y., & Han, J. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.12.013 · Cited by 19 · see citing works

Adult Muscle Stem Cells: Exploring the Links Between Systemic and Cellular Metabolism

Purohit, G., & Dhawan, J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00312 · Cited by 17 · see citing works

Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Sousa‐Victor, P., Neves, J., & Muñoz‐Cánoves, P. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111246 · Cited by 18 · see citing works

Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age

Ramírez‐Pardo, I., Campanario, S., Chavda, B., Santiago‐Fernández, O., Flández, M., Grima-Terrén, M., Cisneros, A., Calls, A., Itzhak, D. N., Ngo, B., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01411-w · Cited by 14 · see citing works

Aging‐Related Rotator Cuff Tears: Molecular Mechanisms and Implications for Clinical Management

Wang, N., Wang, H., Shen, L., Liu, X., Ma, Y., & Wang, C. (2024) · Advanced Biology · doi:10.1002/adbi.202300331 · Cited by 14 · see citing works

Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms

Martins, S. G., Ribeiro, V., Melo, C., Paulino-Cavaco, C., Antonini, D., Naidu, S. D., Murtinheira, F., Fonseca, I. T. E., Saget, B., Pita, M., et al. (2024) · Life Science Alliance · doi:10.26508/lsa.202402829 · Cited by 15 · see citing works

Autophagy in Muscle Regeneration: Mechanisms, Targets, and Therapeutic Perspective

Chu, Y., Yuan, X., Tao, Y., Yang, B. T., & Luo, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211901 · Cited by 16 · see citing works

Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review

Wang, L., Guo, D., Huang, Y., Long, P., Zhang, X., Bai, L., Liu, J., Hu, X., Pang, R., & Gou, X. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1472413 · Cited by 14 · see citing works

Muscle regeneration and muscle stem cells in metabolic disease

Chung, J. D., Porrello, E. R., & Lynch, G. S. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.041 · Cited by 15 · see citing works

Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis

Huffman, K. M., Andonian, B. J., Abraham, D., Bareja, A., Lee, D. E., Katz, L. H., Huebner, J. L., Kraus, W. E., & White, J. P. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00576.2020 · Cited by 14 · see citing works

Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle

Bareja, A., Draper, J. A., Katz, L. H., Lee, D. E., Grimsrud, P. A., & White, J. P. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111443 · Cited by 13 · see citing works

Metabolic Regulation of Stem Cells in Aging

Keller, A. R., Temple, T., Sayanjali, B., & Mihaylova, M. M. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00186-6 · Cited by 13 · see citing works

Targeting autophagy drug discovery: Targets, indications and development trends

Jiang, M., Wu, W., Xiong, Z., Ye, Z., Ye, Z., & Wu, Z. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116117 · Cited by 13 · see citing works

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT

Bareja, A., Lee, D. E., Ho, T., Waitt, G. M., McKay, L. K., Hannou, S. A., Orenduff, M. C., McGreevy, K. M., Binder, A. M., Ryan, C. P., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113881 · Cited by 12 · see citing works

Androgen depletion alters the diurnal patterns to signals that regulate autophagy in the limb skeletal muscle

Rossetti, M. L., Tomko, R. J., & Gordon, B. S. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03963-9 · Cited by 13 · see citing works

AMPK Phosphorylation Impacts Apoptosis in Differentiating Myoblasts Isolated from Atrophied Rat Soleus Muscle

Vilchinskaya, N. A., Rozhkov, S. V., Turtikova, O. V., Mirzoev, T. M., & Shenkman, B. S. (2023) · Cells · doi:10.3390/cells12060920 · Cited by 11 · see citing works

Satellite Cells are Activated in a Rat Model of Radiation-Induced Muscle Fibrosis

Zeng, X., Xie, L., Ge, Y., Zhou, Y., Wang, H., Chen, Y., Zhu, X., Liu, H., Liao, Q., Kong, Y., et al. (2022) · Radiation Research · doi:10.1667/rade-21-00183.1 · Cited by 10 · see citing works

A Reassessment of Sarcopenia from a Redox Perspective as a Basis for Preventive and Therapeutic Interventions

Arcaro, A., Lepore, A., Cetrangolo, G. P., Paventi, G., Ames, P. R. J., & Gentile, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167787 · Cited by 10 · see citing works

Skeletal muscle-specific inducible AMPKα1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy

Petrocelli, J. J., Liu, J., Yee, E. M., Ferrara, P. J., Bourrant, P., de Hart, N. M. M. P., Tatum, S. M., Holland, W. J., Funai, K., & Drummond, M. J. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00261.2023 · Cited by 10 · see citing works

Exploring the potential regulation of DUOX in thyroid hormone‑autophagy signaling via IGF‑1 in the skeletal muscle (Review)

Then, A. H., Goenawan, H., Lesmana, R., Christoper, A., Sylviana, N., & Gunadi, J. W. (2024) · Biomedical Reports · doi:10.3892/br.2024.1917 · Cited by 9 · see citing works

Mechanisms of Exercise in Improving Sarcopenia

Su, M., Shao, Y., Fang, Q., Li, Y., Qiu, F., Che, T., & Zhang, S. (2025) · Comprehensive physiology · doi:10.1002/cph4.70030 · Cited by 8 · see citing works

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Plessis‐Belair, J., Russo, T., Rießland, M., & Sher, R. B. (2025) · Aging Cell · doi:10.1111/acel.70091 · Cited by 7 · see citing works

The cellular ecosystem of skeletal muscle regeneration: molecular mechanisms, pathological disorders, and potential therapeutic strategies

Gong, J., Hong-yi, X., Yao, X., Wei, Y. J., Li, X., Shen, Y., Chen, B., & Sun, H. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05060-y · Cited by 6 · see citing works

Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair

Qiu, M., Li, Y., Wang, Q., Jian, X., Huang, J.-W., Gui, W., Hu, J., & Liao, H. (2025) · Aging and Disease · doi:10.14336/ad.2024.1501 · Cited by 6 · see citing works

δ-Catenin promotes cell migration and invasion via Bcl-2-regulated suppression of autophagy in prostate cancer cells.

Chen, Z., Lee, H. J., Kim, H., Cho, S., & Kim, K. (2022) · PubMed Central · Cited by 6 · see citing works

Recent advances in cell‐based and cell‐free therapeutic approaches for sarcopenia

Wu, S., Lin, S., Zhang, X., Alizada, M., Wang, L., Zheng, Y., Ke, Q., & Xu, J. (2022) · The FASEB Journal · doi:10.1096/fj.202200675r · Cited by 6 · see citing works

The impact of cellular senescence on aging skeletal muscle

Kamal, M. J., Bevington, R. T., Johnson, A., & Parise, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1719279 · Cited by 6 · see citing works

Chronic treatment of old mice with AICAR reverses age‐related changes in exercise performance and skeletal muscle gene expression

Wilcox, S. H., Calixto, J., Dray, S. D., Rasch, D. M., Smith, A. H., Brodowski, K. D., Hill, J. T., & Thomson, D. M. (2025) · FASEB BioAdvances · doi:10.1096/fba.2024-00252 · Cited by 5 · see citing works

OR2H2 Activates CAMKKβ–AMPK–Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells

Kim, J. M., Dziobaka, S., Yoon, Y. E., Lee, H. L., Jeong, J. H., Lee, I.-R., Weidinger, D., Yang, C., Kim, D., Yalcin, G., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16091221 · Cited by 5 · see citing works

Cinnamic acid-GPR109A pathway improves skeletal muscle hypertrophy and metabolism

Ma, Z., Li, P., Feng, X., Zhu, Y., Fan, L., Xu, G., Wang, L., Wang, S., Wu, R., Zhu, C., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156851 · Cited by 4 · see citing works

Stem Cell Aging and Rejuvenation in the Skeletal Muscle System

Libergoli, M., & Almada, A. E. (2025) · Rejuvenation Research · doi:10.1089/rej.2025.0028 · Cited by 4 · see citing works

Treating age‐related loss of muscle mass and function: Where should we be focusing?

Ham, D. J., Fry, C. S., Ruparelia, A. A., Ngo, S. T., & Lamon, S. (2026) · The Journal of Physiology · doi:10.1113/jp289838 · Cited by 5 · see citing works

Prognostic significance of p27 in colorectal cancer: a meta-analysis and bioinformatics analysis

Zou, J., Wang, D., Yin, G., Lu, K., Chang, K., & Li, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1495476 · Cited by 3 · see citing works

Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis

Lee, D. E., McKay, L. K., Bareja, A., Yang, J., He, W., Hill, D. A., Bain, J. R., Kuang, S., Zhang, G.-F., Newgard, C. B., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01120-3 · Cited by 3 · see citing works

Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitis

Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00028 · Cited by 3 · see citing works

Identification of shared biomarkers for obstructive sleep apnea and sarcopenia via differential expression and WGCNA analysis

Jiang, F., Xu, Y., Zheng, B., Zhang, G.-L., & Li, R.-H. (2026) · Sleep And Breathing · doi:10.1007/s11325-026-03633-y · Cited by 2 · see citing works

Altered Expression of Cell Cycle Regulators and Factors Released by Aged Cells in Skeletal Muscle of Patients with Bone Fragility: A Pilot Study on the Potential Role of SIRT1 in Muscle Atrophy

Falvino, A., Bonanni, R., Gasperini, B., Cariati, I., Chiavoghilefu, A., Smakaj, A., Visconti, V. V., Botta, A., Iundusi, R., Gasbarra, E., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13061350 · Cited by 2 · see citing works

The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer

Zhu, M., Huang, L., Sun, S., Chen, M., Cai, J., Zhang, Y., Wang, L., Cai, L., & Peng, M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111011 · Cited by 2 · see citing works

Hemp seed extract exerts cytostatic effects through metabolic stress and autophagy modulation in malignant cells

Moccia, S., Russo, M., Cervellera, C., Crescente, G., Spagnuolo, C., & Russo, G. L. (2026) · Scientific Reports · doi:10.1038/s41598-026-37119-4 · Cited by 1 · see citing works

Suppression of neuronal p27 impairs cognitive function in middle-aged mice

Nicol, N. I., Patel, J. V., Jester, H. M., Swift, N. A., Wang, X., Wu, N., Zhou, X., Zhang, Y., & Ma, T. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107440 · Cited by 1 · see citing works

Linking mitochondrial dysfunction to sarcopenia

Alway, S. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00004-1 · Cited by 1 · see citing works

Stem Cells and Aging

Perdiguero, E., García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00138-3 · Cited by 1 · see citing works

Defect of autophagy signaling in sarcopenic muscle

Sakuma, K., Yamaguchi, A., & Matsuo, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00001-6

Exercise-Induced Autophagy in the Prevention and Treatment of Sarcopenia

Fan, J., Mo, X., Zou, K., & Chen, N. (2021) · Springer eBooks · doi:10.1007/978-981-16-4525-9_10

OR2H2 Activation Suppresses Cellular Senescence and Aging by Activating AMPK and Inducing Senolysis in VK2/E6E7 CellsPreprint

Kim, J. M., Dziobaka, S., Yoon, Y. E., Lee, H. L., Jeong, J. H., Lee, I.-R., Weidinger, D., Yang, C., Kim, D., Yalcin, G., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2020909/v1

Autophagy in Muscle Stem Cells

Li, S., Filippelli, R. L., Nam, A. J., & Chang, N. C. (2022) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-031-17362-2_6

Role of cyclooxygenase-2 in ischemia-reperfusion injury in the liver

Fuertes‐Agudo, M. (2023) · doi:10.4995/thesis/10251/196602

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcificationPreprint

Hold, L. A., Migotsky, N., Lamia, S. N., Steltzer, S. S., Grossman, S., Chen, J. A., Bae, S.-H., Cordts, P., Phillips, T., O’Meara, M. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.31.635920

Early Taurine Administration Decreases the Levels of Receptor-Interacting Serine/Threonine Protein Kinase 1 in the Duchenne Mouse Model mdx

Dias, M., Dhuyvetter, H., Byttebier, E., Merckx, C., Bleecker, J. D., & Paepe, B. D. (2025) · Brain Sciences · doi:10.3390/brainsci15111175

NRMLncR, a myocyte-enriched long non-coding RNA, enhances myogenesis in mousePreprint

Li, Y., Zhou, Y., Li, Q. Y., Arrington, J. V., Abdelhai, M. F., Wang, Y., Ren, J., Cheng, Y.-Y., Xie, M., Tao, W. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.11.704964

Resistance-based exercise restores muscle health in dialysis patients

Srivastava, P., Singh, S. K., Nair, R. S., Jha, S., Viswakarma, N., Srivastava, D., Hachaj, G., Bartlett, S. T., Santi, I., Ejaz, A. M., et al. (2026) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-026-09727-0

Circular RNA CircMYH8 regulates muscle proliferation, apoptosis and differentiation via binding miR-221 to activate p27

Yang, S., Yang, H., Zhang, X., Yang, Y., Tang, J., Qi, A., Dong, W., Wang, D., Huang, X., Huang, B., et al. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.102970

Modulation of satellite cell function to alleviate age-related sarcopenia: Electrical stimulation & Ca²⁺ signaling combined approach

Chen, C. J., Mulat, Y., Jiang, D., & Lin, H. (2026) · iScience · doi:10.1016/j.isci.2026.116296

Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions

Chai, Y., Liu, X., Bi, J., Zeng, J., Yao, M., Shi, F., & Xu, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103204

Orchestration of Autophagy and Senescence: Kinases Take the Center Stage

Basu, A. (2026) · Cells · doi:10.3390/cells15131176

Autophagy maintains stemness by preventing senescence

García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355 · see citing works

Stemness maintenance in skeletal muscle : a focus on aging

García‐Prat, L. (2015) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors

Lukjanenko, L., Karaz, S., Stuelsatz, P., Gurriaran-Rodriguez, U., Michaud, J., Dammone, G., Sizzano, F., Mashinchian, O., Ancel, S., Migliavacca, E., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2018.12.014 · Cited by 374 · see citing works

The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells

McKay, L. K., & White, J. P. (2021) · Cells · doi:10.3390/cells10061430 · Cited by 36 · see citing works

Dysfunctional autophagy is a driver of muscle stem cell functional decline with aging

García-Prat, L., Muñoz-Cánoves, P., & Martinez-Vicente, M. (2016) · Autophagy · doi:10.1080/15548627.2016.1143211 · Cited by 70 · see citing works