Cited by 188Epigenetics and DNA MethylationAir Quality and Health ImpactsHealth, Environment, Cognitive Aging

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIR ON AGE birth cohort study

Open access

Janssen, Bram G, Byun, Hyang-Min, Gyselaers, Wilfried, Lefebvre, Wouter, Baccarelli, Andrea A, Nawrot, Tim S·2015·Epigenetics

DOI 10.1080/15592294.2015.1048412PMC PMC4623402

Open this paper in CoChat — free account Open PDF

Abstract

Most research to date has focused on epigenetic modifications in the nuclear genome, with little attention devoted to mitochondrial DNA (mtDNA). Placental mtDNA content has been shown to respond to environmental exposures that induce oxidative stress, including airborne particulate matter (PM). Damaged or non-functioning mitochondria are specifically degraded through mitophagy, exemplified by lower mtDNA content, and could be primed by epigenetic modifications in the mtDNA. We studied placental mtDNA methylation in the context of the early life exposome. We investigated placental tissue from 381 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. We determined mtDNA methylation by bisulfite-pyrosequencing in 2 regions, i.e., the D-loop control region and 12S rRNA (MT-RNR1), and measured mtDNA content by qPCR. PM2.5 exposure was calculated for each participant's home address using a dispersion model. An interquartile range (IQR) increment in PM2.5 exposure over the entire pregnancy was positively associated with mtDNA methylation (MT-RNR1: +0.91%, P = 0.01 and D-loop: +0.21%, P = 0.05) and inversely associated with mtDNA content (relative change of -15.60%, P = 0.001) in placental tissue. mtDNA methylation was estimated to mediate 54% [P = 0.01 (MT-RNR1)] and 27% [P = 0.06 (D-loop)] of the inverse association between PM2.5 exposure and mtDNA content. This study provides new insight into the mechanisms of altered mitochondrial function in the early life environment. Epigenetic modifications in the mitochondrial genome, especially in the MT-RNR1 region, substantially mediate the association between PM2.5 exposure during gestation and placental mtDNA content, which could reflect signs of mitophagy and mitochondrial death.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/15592294.2015.1048412

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Figure 1. Location of mitochondrial targets in the human mitochondrial genome. The double stranded, circular mtDNA (16569 bp) contains 37 genes, specifying 13 polypeptides (blue boxes), 2 rRNAs, i.e., 12S rRNA and 16S rRNA (orange boxes), and 22 tRNAs (yellow boxes). The single letter codon associated with the yellow box refers to the amino acid. The D-loop region (green box) contains the origin of replication and is the place where promoters initiate transcription of the H-strand. The target location for DNA methylation analysis in the D-loop and MT-RNR1 region are denoted by the black arcs, with magnified pyrograms. The red arcs depict the targets for mtDNA content analysis (MTF3212/R3319 and ND1). NADH dehydrogenase (ND); Cytochrome c oxidase (COX); F1F0-ATP synthase (ATPase); Cytochrome b (Cyt b).CC BY-NC · PubMed Central

Figure 2. Correlation of mtDNA methylation and mtDNA content in placental tissue. Placental mtDNA content is log10-transformed. Methylation levels are indicated as absolute percentage levels. (A) MT-RNR1 methylation levels. (B) D-loop methylation levels.CC BY-NC · PubMed Central

Figure 3. Estimated proportion of effects of PM2.5 exposure during gestation on mtDNA content mediated through changes in mtDNA methylation. The figure displays placental mtDNA methylation as mediator [(A) MT-RNR1; (B) D-loop], the estimates of indirect effect (IE), the estimates of the direct effect (DE), and proportion of mediation (IE/DE+IE). The effects are relative changes in placental mtDNA content for an IQR increment of PM2.5 exposure. The mediation model was adjusted for gender, age, gestational age, smoking, maternal education, parity, ethnicity, and season at conception.CC BY-NC · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
Hellemans, J., Mortier, G., De Paepe, A., Speleman, F., & Vandesompele, J. (2007) · Genome Biology · doi:10.1186/gb-2007-8-2-r19 · Cited by 4,023
Mediation analysis allowing for exposure–mediator interactions and causal interpretation: Theoretical assumptions and implementation with SAS and SPSS macros.
Valeri, L., & VanderWeele, T. J. (2013) · Psychological Methods · doi:10.1037/a0031034 · Cited by 2,132
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Mitophagy: mechanisms, pathophysiological roles, and analysis
Ding, W.-X., & Yin, X.-M. (2012) · bchm · doi:10.1515/hsz-2012-0119 · Cited by 1,032
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
Stern, S. T., Adiseshaiah, P. P., & Crist, R. M. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-20 · Cited by 865
Ambient Air Pollution and Pregnancy Outcomes: A Review of the Literature
Šrám, R. J., Binková, B., Dejmek, J., & Bobák, M. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.6362 · Cited by 685
Mitochondrial DNA mutations in disease and aging
Wallace, D. C. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20586 · Cited by 622
Mitochondria as a Target of Environmental Toxicants
Meyer, J. N., Leung, M. C. K., Rooney, J. P., Sendoel, A., Hengartner, M. O., Kisby, G. E., & Bess, A. S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft102 · Cited by 587
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
Shock, L. S., Thakkar, P. V., Peterson, E. J., Moran, R. G., & Taylor, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012311108 · Cited by 555

Show all 45 references

Research works printed but not linked: 2

Chistiakov DA, 2014, BioMed Res Int, 2014, Article ID 2384
Feng S, 2012, Mol Med Rep, 6, 125

Sorted by citations

Items 101–188 of 188

Association between prenatal exposure to cooking oil fumes and full-term low birth weight is mediated by placental weight
Hu, P., Fan, L., Ding, P., He, Y., Xie, C., Niu, Z., Tian, F., Yuan, S., Jia, D., & Chen, W. (2018) · Environmental Research · doi:10.1016/j.envres.2018.08.014 · Cited by 24
Association between mitochondrial DNA methylation and internal exposure to polycyclic aromatic hydrocarbons (PAHs), nitrated-PAHs (NPAHs) and oxygenated-PAHs (OPAHs) in young adults from Tianjin, China
Guo, L., Liu, Z., Li, P., Ji, Y., Song, S., Zheng, N., Zhao, L., Jia, Y., Fang, J., Wang, H., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113799 · Cited by 21
Self-citation
Targeted Mitochondrial Epigenetics: A New Direction in Alzheimer’s Disease Treatment
Song, Y., Zhu, X., Zhang, X.-M., & Xiong, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179703 · Cited by 21
The prenatal environment and its influence on maternal and child mitochondrial DNA copy number and methylation: A review of the literature
Smith, A. R., Briseño, A. H., Picard, M. A., & Cárdenas, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115798 · Cited by 20
Prenatal exposure to environmental pro-oxidants induces mitochondria-mediated epigenetic changes: a cross-sectional pilot study
Mishra, P. K., Kumari, R., Bhargava, A., Bunkar, N., Chauhan, P., Tiwari, R. R., Shandilya, R., Srivastava, R. K., & Singh, R. D. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-21059-3 · Cited by 20
Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA)
Peng, C., den Dekker, M. A. M., Cárdenas, A., Rifas‐Shiman, S. L., Luttmann‐Gibson, H., Agha, G., Harris, M. H., Coull, B. A., Schwartz, J. D., Litonjua, A. A., et al. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2034 · Cited by 20
Self-citation
Association of Prenatal Ambient Air Pollution Exposure With Placental Mitochondrial DNA Copy Number, Telomere Length and Preeclampsia
Mandakh, Y., Oudin, A., Erlandsson, L., Isaxon, C., Hansson, S. R., Bröberg, K., & Malmqvist, E. (2021) · Frontiers in Toxicology · doi:10.3389/ftox.2021.659407 · Cited by 18
Maternal Fructose Intake, Programmed Mitochondrial Function and Predisposition to Adult Disease
Smith, E. V. L., Dyson, R. M., Weth, F. R., Berry, M. J., & Gray, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012215 · Cited by 20
Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats
Miller, C. N., Kodavanti, U. P., Stewart, E. J., Schaldweiler, M., Richards, J. H., Ledbetter, A. D., Jarrell, L. T., Snow, S. J., Henriquez, A. R., Farraj, A. K., et al. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.12.002 · Cited by 18
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL
Zhang, J., Shang, J., Wang, F., Huo, X., Sun, R., Ren, Z., Wang, W., Yang, M., Li, G., Gao, D., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-021-01225-z · Cited by 18
Fetal and obstetrics manifestations of mitochondrial diseases
Adelizzi, A., Anastasia, G., Donfrancesco, A. D., Boito, S., Prigione, A., Bottani, E., Bollati, V., Tiranti, V., Persico, N., & Brunetti, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05633-6 · Cited by 18
Air pollution and placental mitochondrial DNA copy number: Mechanistic insights and epidemiological challenges
Li, Z., Fu, J., Zhou, L., Tang, Y., Hua, Q., Liu, L., & Zhao, J. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113266 · Cited by 19
Prenatal PM2.5 exposure and the risk of adverse births outcomes: Results from Project ELEFANT
Fang, J., Kang, C., Osorio-Yáñez, C., Barrow, T. M., Zhang, R., Zhang, Y., Li, C., Liu, H., Li, P., Guo, L., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110232 · Cited by 17
Self-citation
Effects of fine particulate matter mass and chemical components on oxidative DNA damage in human early placenta
Chu, M., Yang, J., Gong, C., Li, X., Wang, M., Han, B., Huo, Y., Wang, J., Bai, Z., & Zhang, Y. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120136 · Cited by 16
Gestational exposure to air pollutants perturbs metabolic and placenta-fetal phenotype
Ganguly, A., Ghosh, S., Shin, B., Touma, M., Wadehra, M., & Devaskar, S. U. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108657 · Cited by 15
Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns
Nazzari, S., Cagliero, L., Grumi, S., Pisoni, E., Mallucci, G., Bergamaschi, R. C., Maccarini, J., Giorda, R., & Provenzi, L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02206-9 · Cited by 18
Methodology for Accurate Detection of Mitochondrial DNA Methylation
Mechta, M., Ingerslev, L. R., & Barrès, R. (2018) · Journal of Visualized Experiments · doi:10.3791/57772 · Cited by 15
From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases
Donato, L., Mordà, D., Scimone, C., Alibrandi, S., D’Angelo, R., & Sidoti, A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.03.025 · Cited by 15
Global research trends on the human exposome: a bibliometric analysis (2005–2024)
Petit, P., & Vuillerme, N. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-36197-7 · Cited by 16
Epigenetic Alterations and Exposure to Air Pollutants: Protocol for a Birth Cohort Study to Evaluate the Association Between Adverse Birth Outcomes and Global DNA Methylation
Maghbooli, Z., Hossein‐Nezhad, A., Ramezani, M., & Moattari, S. (2017) · JMIR Research Protocols · doi:10.2196/resprot.7114 · Cited by 13
Lupus, DNA Methylation, and Air Pollution: A Malicious Triad
Rasking, L., Roelens, C., Sprangers, B., Thienpont, B., Nawrot, T. S., & Vusser, K. D. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192215050 · Cited by 13
Self-citation
Identification of key genes in the tumor microenvironment of lung adenocarcinoma
Long, W., Li, Q., Zhang, J., & Xie, H. (2021) · Medical Oncology · doi:10.1007/s12032-021-01529-3 · Cited by 11
Association between Maternal Short-Term Exposure to Ambient Air Pollution and the Risk of Fetal Distress: A Matched Case-Control Study
Xiao, H., Yao, C., Qi, Z., Liu, J., Liu, X., Zhou, Y., Tang, E., Hu, Y.-G., Jiang, Y., Li, D., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.160438 · Cited by 10
The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates
Lees, J. J., Pértille, F., Løtvedt, P. K., Jensen, P., & Guerrero‐Bosagna, C. (2023) · BMC Genomics · doi:10.1186/s12864-023-09668-9 · Cited by 11
Small but Mighty: Prenatal Ultrafine Particle Exposure Linked to Childhood Asthma Incidence
Wright, R. J., & Coull, B. A. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0506ed · Cited by 10
Diet, Trimethylamine Metabolism, and Mitochondrial DNA: An Observational Study
Bordoni, L., Malinowska, A. M., Petracci, I., Szwengiel, A., Gabbianelli, R., & Chmurzyńska, A. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200003 · Cited by 10
Nutrition, Other Environmental Influences, and Genetics in the Determination of Human Stature
Lui, J. C. K., Palmer, A., & Christian, P. S. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061121-091112 · Cited by 10
Air pollution-linked epigenetic modifications in placental DNA: Prognostic potential for identifying future foetal anomalies
Kumar, S. H., Acharyya, S., Chouksey, A., Soni, N., Nazeer, N., & Mishra, P. K. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108675 · Cited by 9
Polyurethane foam induces epigenetic modification of mitochondrial DNA during different metamorphic stages of Tenebrio molitor
Guo, B., Yin, J., Hao, W., & Jiao, M. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109461 · Cited by 12
Maternal Fructose Intake Causes Developmental Reprogramming of Hepatic Mitochondrial Catalytic Activity and Lipid Metabolism in Weanling and Young Adult Offspring
Smith, E. V. L., Dyson, R. M., Vanderboor, C., Sarr, O., Anderson, J., Berry, M. J., Regnault, T. R. H., Peng, L., & Gray, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020999 · Cited by 11
Epigenetics and the Exposome
Plusquin, M., Saenen, N. D., & Nawrot, T. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-89321-1_5 · Cited by 9
Self-citation
Mitochondrial Quality Control in Bovine Oocyte Maturation: Mechanisms, Challenges, and Prospects for Enhancing Reproductive Efficiency
Zhang, Y.-R., & Xu, D. (2025) · Animals · doi:10.3390/ani15132000 · Cited by 8
Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation
Li, W.-X., Guo, L.-Q., Fang, J., Zhao, L., Song, S., Fang, T., Li, C., Wang, L., & Li, P.-H. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1108555 · Cited by 10
Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review
Mishra, S., Stukken, C. V. D., Drury, S., Nawrot, T. S., & Martens, D. S. (2024) · Environmental Research · doi:10.1016/j.envres.2023.117990 · Cited by 7
Self-citation
RACK1 may participate in placental development at mid‐gestation via regulating trophoblast cell proliferation and migration in pigs
Wu, Z., Hu, G., Gong, T., Hu, Q., Hong, L., Zhang, Y., & Ao, Z. (2023) · Molecular Reproduction and Development · doi:10.1002/mrd.23680 · Cited by 8
Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months
Miller, R. L., Rivera, J. A., Lichtiger, L., Govindarajulu, U. S., Jung, K. H., Lovinsky‐Desir, S., Perera, F. P., Balcer-Whaley, S. L., Newman, M. G., Grant, T. L., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117342 · Cited by 7
Global warming, pollution and cognitive developments
Horvath, D., & Borgonovi, F. (2022) · OECD social employment and migration working papers · doi:10.1787/319b9a1f-en · Cited by 12
Unveiling the Interconnected Dynamics of Mitochondrial Dysfunction Associated With Age-Related Cardiovascular Risk: A Cross-Sectional Pilot Study
Soni, N., Kaur, P., Gurjar, V., Bhargava, A., Tiwari, R. R., Chouksey, A., Srivastava, R. K., & Mishra, P. K. (2025) · Cureus · doi:10.7759/cureus.82961 · Cited by 8
Alterations in the placental proteome in association with the presence of black carbon particles: A discovery study
Millen, J. L., Luyten, L. J., Dieu, M., Bové, H., Ameloot, M. M., Bongaerts, E., Demazy, C., Fransolet, M., Martens, D. S., Renard, P., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120214 · Cited by 6
Self-citation
Comparison between D-loop methylation and mtDNA copy number in patients with Aicardi-Goutières Syndrome
Dragoni, F., Garau, J., Orcesi, S., Varesio, C., Bordoni, M., Scarian, E., Gerlando, R. D., Fazzi, E. M., Battini, R., Gjurgjaj, A., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1152237 · Cited by 6
Framing Fetal and Early Life Exposome Within Epidemiology
Laine, J. E., & Robinson, O. (2018) · Springer eBooks · doi:10.1007/978-3-319-89321-1_4 · Cited by 6
Air pollutants in bronchoalveolar lavage fluid and pulmonary tuberculosis: A mediation analysis of gene-specific methylation
Liu, Q., Ji, Y., Wang, L., Li, Z., Tao, B., Zhu, L., Lu, W., Martínez, L., Zeng, Y., & Wang, J. (2023) · iScience · doi:10.1016/j.isci.2023.108391 · Cited by 5
Analysis of mitochondrial genome methylation using Nanopore single-molecule sequencingPreprint
Lüth, T., Klein, C., Schaake, S., Tse, R., Pereira, S. L., Laß, J., Sinkkonen, L., Grünewald, A., & Trinh, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.05.429923 · Cited by 5
DNA damage and its association with early-life exposome: Gene-environment analysis in Colombian children under five years old
Marín, D., Narváez, D. M., Sierra, A., Molina, J. S., Ortiz, I. C., Builes, J. J., Morales, O., Cuellar, M., Corredor, A., Villamil‐Osorio, M., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108907 · Cited by 4
Mitochondrial DNA content and methylation in sperm of patients with asthenozoospermia
Geng, Q., Gao, R., Sun, Y., Chen, S., Sun, L., Li, W., Li, Z., Zhao, Y., Zhao, F., Zhang, Y., et al. (2024) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-024-03236-0 · Cited by 5
Associations between Circulating Biomarkers of One-Carbon Metabolism and Mitochondrial D-Loop Region Methylation Levels
Stoccoro, A., Lari, M., Migliore, L., & Coppedè, F. (2024) · Epigenomes · doi:10.3390/epigenomes8040038 · Cited by 4
The association of prenatal ambient air pollution with placental epigenetic gestational age at birth
He, Z., Song, A., Schrott, R., Feinberg, J. I., Bakulski, K. M., Benke, K. S., Croen, L., Hertz‐Picciotto, I., Schmidt, R. J., Lyall, K., et al. (2025) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000384 · Cited by 4
Air Pollution Effects in Pregnancy
Marca, L. L., & Gava, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-62731-1_26 · Cited by 4
Associations between antenatal maternal asthma status and placental DNA methylation
Lee, A., Tignor, N. L., Cowell, W., Colicino, E., Bozack, A. K., Baccarelli, A., Wang, P., & Wright, R. J. (2022) · Placenta · doi:10.1016/j.placenta.2022.06.008 · Cited by 4
Self-citation
Biomarkers and omics of health effects associated with traffic-related air pollution
Demetriou, C. A., & Vineis, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818122-5.00011-9 · Cited by 4
Low lung function in the developing world is analogous to stunting: a review of the evidence
Mishra, N., Salvi, S., Lyngdoh, T., & Agrawal, A. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15929.1 · Cited by 5
From exposure to outcomes: How air pollutants impact maternal and foetal health
Parikh, G., & Patel, B. M. (2025) · Reproductive Toxicology · doi:10.1016/j.reprotox.2025.109080 · Cited by 3
“Whole genome bisulfite sequencing of serum extracellular vesicle DNA identifies alterations in mitochondrial DNA methylation in early onset preeclampsia”
Shinde, U., Khambata, K., Raut, S., Rao, A. A., Bansal, V., Mayadeo, N., Das, D. K., Madan, T., Gunasekaran, V. P., & Balasinor, N. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120168 · Cited by 3
MitoepigenomeKB a comprehensive resource for human mitochondrial epigenetic data
Ghosh, S., Ranawat, A. S., Tolani, P., & Scaria, V. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.11.001 · Cited by 3
Cross‐Cohort Mixture Analysis: A Data Integration Approach With Applications on Gestational Age and DNA‐Methylation‐Derived Gestational Age Acceleration Metrics
Colicino, E., Ascari, R., Saddiki, H., Merced‐Nieves, F. M., Pedretti, N. F., Huddleston, K., Wright, R. O., Wright, R. J., & Outcomes, P. C. F. E. I. O. C. H. (2024) · Biometrical Journal · doi:10.1002/bimj.202300270 · Cited by 3
Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring
Zhang, K., Tian, L., Sun, Q., Lv, J., Ding, R., Yu, Y., Yang, L., & Duan, J. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104585 · Cited by 4
The effects of air pollution toxicants on the mitochondria
Kochi, C., Ahmad, S., & Salim, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-88462-4.00004-3 · Cited by 3
Maternal mitochondrial DNA copy number and methylation as possible predictors of pregnancy outcomes in a Michigan pregnancy cohort
Cinzori, M. E., Nicol, M., Dewald, A., Goodrich, J. M., Zhou, Z., Gardiner, J. C., Kerver, J. M., Dolinoy, D. C., Talge, N. M., & Strakovsky, R. S. (2024) · Current Zoology · doi:10.1093/eep/dvae021 · Cited by 2
Impacts of PM 2.5 on stillbirth and the potential mechanism: a narrative review
Li, Z., Liu, R., & Zhang, E. (2025) · Reviews on Environmental Health · doi:10.1515/reveh-2025-0090 · Cited by 2
Associations between prenatal exposure to ambient air pollutants and preterm birth in the Atlanta African American maternal-child cohort
Tan, Y., Li, Z., Dunlop, A. L., Ren, M., Chang, H. H., Jin, Z., Sarnat, J. A., Huels, A., Eick, S. M., Ekenga, C. C., et al. (2026) · Environmental Health · doi:10.1186/s12940-026-01264-0 · Cited by 2
Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings
Hahad, O., Kuntić, M., Al-Kindi, S. G., Lelieveld, J., Cheng, Y., Schmitt, V. H., Hobohm, L. H., Keller, K., Kerahrodi, J. G., Faridi, S., et al. (2026) · Journal of Environmental Health Science and Engineering · doi:10.1007/s40201-026-00990-4 · Cited by 2
Causal Mediation Analysis in Pregnancy Studies: the Case of Environmental Epigenetics
Valeri, L. (2017) · Current Epidemiology Reports · doi:10.1007/s40471-017-0112-1 · Cited by 2
The potential role of environmental factors in modulating mitochondrial DNA epigenetic marks
Ryva, B. A., Zhou, Z., Goodrich, J. M., & Strakovsky, R. S. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.01.011 · Cited by 2
Omega-3 reverses the metabolic and epigenetically regulated placental phenotype acquired from preconceptional and peri-conceptional exposure to air pollutants
Ganguly, A., Ghosh, S., Jin, P., Wadehra, M., & Devaskar, S. U. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109735 · Cited by 2
Association of PPARGC1A gene polymorphism and mtDNA methylation with coal-burning fluorosis: a case–control study
Song, J., Zhao, A., Li, R., Luo, Y., Dong, Y., Wang, C., Zhang, T., Deng, J., Qi, X., Guan, Z., et al. (2024) · BMC Genomics · doi:10.1186/s12864-024-10819-9 · Cited by 2
Associations of maternal PM2.5 exposure with preterm birth and miscarriage in women undergoing in vitro fertilization: a retrospective cohort study
Chen, M., Chen, Q., Liao, G., Sun, C., Liu, C., Meng, X., Li, W., Qiu, A., Bükülmez, O., Kan, H., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1460976 · Cited by 2
Effects of periconceptional ethanol on mitochondrial content and oxidative stress in maternal liver and placentas from male and female fetuses in rats
Steane, S. E., Das, T., Kalisch-Smith, J. I., Mahaliyanage, D. T., Akison, L. K., Moritz, K. M., & Cuffe, J. S. M. (2025) · The Journal of Physiology · doi:10.1113/jp287566 · Cited by 2
Epigenetic Epidemiology for Cancer Risk
Barrow, T. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809552-2.00008-5 · Cited by 2
Ambient air pollution and human epigenetic modifications
Xu, R., Li, S., Abramson, M. J., & Guo, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820951-6.00010-7 · Cited by 2
A global systematic review and meta-analysis on preterm birth and air pollution exposure
Kermani, M., Kashani, H., & Nakhjirgan, P. (2026) · Public Health · doi:10.1016/j.puhe.2026.106394 · Cited by 1
Once we were bacteria... mitochondria to infinity and beyond
Bardanzellu, F., Pintus, M. C., Fanos, V., & Marcialis, M. A. (2018) · Journal of pediatric and neonatal individualized medicine · doi:10.7363/080106 · Cited by 2
Interplay between environmental exposure and mitochondrial DNA methylation in disease susceptibility and cancer: a comprehensive review
Sanyal, T., Das, A., Bhowmick, P., & Bhattacharjee, P. (2022) · The Nucleus · doi:10.1007/s13237-022-00392-5 · Cited by 1
Toxicity of environmental pollutants for mitochondrialDNA alteration
Zheng, J. J., Liu, Y., & Wang, H. (2022) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2022-0614 · Cited by 1
INVESTIGATING THE PRESENCE OF MITOCHONDRIAL DNA METHYLATION, ITS ALTERATION AND ASSOCIATION WITH MITOCHONDRIAL TRANSCRIPTION AND MITOCHONDRIAL FUNCTION
Roy, N. (2015) · KU ScholarWorks (University of Kansas)
Introduction: Mitochondria, the Cell Furnaces
Oliveira, P. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_1
Faculty Opinions recommendation of Developmental programming of mitochondrial biology: a conceptual framework and review.
Gunnar, M. R. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737847338.793583368
RACK1 may participate in placental development via regulating proliferation and migration of trophoblast cell in pigs following intrauterine growth restrictionPreprint
Wu, Z., Hu, G., Gong, T., Hu, Q., Hong, L., Zhang, Y., & Ao, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.29.510071
Assessment of the expression patterns of ZNF667-AS1, LINC00662, and ZFP36 and their association with breast cancer patients’ clinicopathologicalPreprint
Baboukani, N. S., Pour-Rouholamin, A., Hounejani, A. E., Rabeh, M., Omidghaemi, S., & Azadeh, M. (2023) · Research Square · doi:10.21203/rs.3.rs-2693492/v1
Additional file 1 of The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates
Lees, J. J., Pértille, F., Løtvedt, P. K., Jensen, P., & Guerrero‐Bosagna, C. (2023) · Figshare · doi:10.6084/m9.figshare.24186085
Reduction in mitochondrial DNA methylation leads to compensatory increase in mitochondrial DNA content: novel blood-borne biomarkers for monitoring occupational noise
Yang, J.-H., Li, Z.-R., Tan, Z.-Z., Liu, W., Hou, Q., Sun, P., & Zhang, X.-T. (2025) · Environmental Health and Preventive Medicine · doi:10.1265/ehpm.25-00006
Study of liana's response to drought stress and assessment of air remediation potential using different experimental models
Hanus-Fajerska, E., Kamińska, I., Kruszyna, C., Kępka, K., Zygmuntowicz, K., Berent, K., Przybysz, A., & Ciarkowska, K. (2025) · Plant and Soil · doi:10.1007/s11104-025-07647-5
Additional file 1 of Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL
Zhang, J., 尚俊奎, Wang, F., Huo, X., Sun, R., Ren, Z., Wang, W., Yang, M., Li, G., Gao, D., et al. (2022) · Figshare · doi:10.6084/m9.figshare.17870239
Additional file 1 of Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C. H., Pendleton, D., Harvey, N., Shore, R. A., Li, Y., Chen, J., Tian, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14966363
Associations of exposure to PM2.5 and its constituents during pregnancy with the risk of premature rupture of membranes in twin pregnancies
Li, Z., Ma, H., Shi, T., Zou, Z., Wang, T., Li, R., & Ren, X. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119611
Maternal PM2.5 exposure causes fetal growth restriction and alters placental morphology: Role of uterine inflammation
Wang, S., Chen, H., Singh, A., Ghevariya, N., & Ying, Z. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109177
Preconception Folic Acid Supplementation Associated with Attenuated Effects of Air Pollution on Birthweight Outcomes
Ge, Y., ZHANG, Y., Liao, J., Lin, Y., Yang, Z., Berhane, K. T., Bai, Z., Han, B., Xu, J., Gilliland, F. D., et al. (2026) · Environment & Health · doi:10.1021/envhealth.5c00779
Low-to-moderate arsenic exposure and DNA methylation: A review of life-course evidence and mechanistic insights
Xiao, H., Peshkova, Y., Wang, L., Lima, F. R., & Guidez, F. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125928
The effects of air pollution toxicants on the mitochondria
Kochi, C., Ahmad, S., & Salim, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00014-2

Authors: Janssen, B. G., Byun, H.-M., Gyselaers, W., Lefebvre, W., Baccarelli, A. A., & Nawrot, T. S.
Affiliations: Hasselt University (BE)
Harvard University (US)
Ziekenhuis Oost-Limburg (BE)
Flemish Institute for Technological Research (BE)
Corresponding author: Nawrot, Tim S
ORCID: Janssen, Bram G
Byun, Hyang-Min
Gyselaers, Wilfried
Lefebvre, Wouter
Baccarelli, Andrea A
Nawrot, Tim S
Venue: Epigenetics
Publisher: Informa UK Limited
Published: 2015-05-21
Volume: 10
Issue: 6
Pages: 536-544
ISSN: 1559-2294 (ISSN-L)
1559-2308
DOI: 10.1080/15592294.2015.1048412
PMC: PMC4623402
OpenAlex: W1828742533
Cited by: 187
References: 45
Citations by year: 2026: 7 · 2025: 11 · 2024: 17 · 2023: 13 · 2022: 23 · 2021: 18 · 2020: 18 · 2019: 15 · 2018: 23 · 2017: 25 · 2016: 15 · 2015: 2
FWCI: 9.40
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Epigenetics (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Document Server@UHasselt (UHasselt) (submittedVersion, cc-by-nc)
Lirias (submittedVersion)
Funders: National Institute of Environmental Health Sciences (R21ES022694, R01ES021733, R01ES021357)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: PM2.5 exposure, airborne particulate matter, mtDNA content, mitophagy, MT-RNR1, D-loop, oxidative stress, ENVIRONAGE birth cohort, mediation analysis
MeSH terms: Environmental Exposure, Female, Humans, Infant, Newborn, Male, Mitochondria, Placenta, Pregnancy, RNA, Ribosomal, Oxidative Stress, DNA Methylation, Epigenesis, Genetic, Particulate Matter, Genome, Mitochondrial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIR ON AGE birth cohort study

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks