Cited by 188Epigenetics and DNA MethylationAir Quality and Health ImpactsHealth, Environment, Cognitive Aging

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIR ON AGE birth cohort study

Open access

Janssen, Bram G, Byun, Hyang-Min, Gyselaers, Wilfried, Lefebvre, Wouter, Baccarelli, Andrea A, Nawrot, Tim S·2015·Epigenetics

DOI 10.1080/15592294.2015.1048412PMC PMC4623402

Open this paper in CoChat — free account Open PDF

Abstract

Most research to date has focused on epigenetic modifications in the nuclear genome, with little attention devoted to mitochondrial DNA (mtDNA). Placental mtDNA content has been shown to respond to environmental exposures that induce oxidative stress, including airborne particulate matter (PM). Damaged or non-functioning mitochondria are specifically degraded through mitophagy, exemplified by lower mtDNA content, and could be primed by epigenetic modifications in the mtDNA. We studied placental mtDNA methylation in the context of the early life exposome. We investigated placental tissue from 381 mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. We determined mtDNA methylation by bisulfite-pyrosequencing in 2 regions, i.e., the D-loop control region and 12S rRNA (MT-RNR1), and measured mtDNA content by qPCR. PM2.5 exposure was calculated for each participant's home address using a dispersion model. An interquartile range (IQR) increment in PM2.5 exposure over the entire pregnancy was positively associated with mtDNA methylation (MT-RNR1: +0.91%, P = 0.01 and D-loop: +0.21%, P = 0.05) and inversely associated with mtDNA content (relative change of -15.60%, P = 0.001) in placental tissue. mtDNA methylation was estimated to mediate 54% [P = 0.01 (MT-RNR1)] and 27% [P = 0.06 (D-loop)] of the inverse association between PM2.5 exposure and mtDNA content. This study provides new insight into the mechanisms of altered mitochondrial function in the early life environment. Epigenetic modifications in the mitochondrial genome, especially in the MT-RNR1 region, substantially mediate the association between PM2.5 exposure during gestation and placental mtDNA content, which could reflect signs of mitophagy and mitochondrial death.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/15592294.2015.1048412

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Figure 1. Location of mitochondrial targets in the human mitochondrial genome. The double stranded, circular mtDNA (16569 bp) contains 37 genes, specifying 13 polypeptides (blue boxes), 2 rRNAs, i.e., 12S rRNA and 16S rRNA (orange boxes), and 22 tRNAs (yellow boxes). The single letter codon associated with the yellow box refers to the amino acid. The D-loop region (green box) contains the origin of replication and is the place where promoters initiate transcription of the H-strand. The target location for DNA methylation analysis in the D-loop and MT-RNR1 region are denoted by the black arcs, with magnified pyrograms. The red arcs depict the targets for mtDNA content analysis (MTF3212/R3319 and ND1). NADH dehydrogenase (ND); Cytochrome c oxidase (COX); F1F0-ATP synthase (ATPase); Cytochrome b (Cyt b).CC BY-NC · PubMed Central

Figure 2. Correlation of mtDNA methylation and mtDNA content in placental tissue. Placental mtDNA content is log10-transformed. Methylation levels are indicated as absolute percentage levels. (A) MT-RNR1 methylation levels. (B) D-loop methylation levels.CC BY-NC · PubMed Central

Figure 3. Estimated proportion of effects of PM2.5 exposure during gestation on mtDNA content mediated through changes in mtDNA methylation. The figure displays placental mtDNA methylation as mediator [(A) MT-RNR1; (B) D-loop], the estimates of indirect effect (IE), the estimates of the direct effect (DE), and proportion of mediation (IE/DE+IE). The effects are relative changes in placental mtDNA content for an IQR increment of PM2.5 exposure. The mediation model was adjusted for gender, age, gestational age, smoking, maternal education, parity, ethnicity, and season at conception.CC BY-NC · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
Hellemans, J., Mortier, G., De Paepe, A., Speleman, F., & Vandesompele, J. (2007) · Genome Biology · doi:10.1186/gb-2007-8-2-r19 · Cited by 4,023
Mediation analysis allowing for exposure–mediator interactions and causal interpretation: Theoretical assumptions and implementation with SAS and SPSS macros.
Valeri, L., & VanderWeele, T. J. (2013) · Psychological Methods · doi:10.1037/a0031034 · Cited by 2,132
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Mitophagy: mechanisms, pathophysiological roles, and analysis
Ding, W.-X., & Yin, X.-M. (2012) · bchm · doi:10.1515/hsz-2012-0119 · Cited by 1,032
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
Stern, S. T., Adiseshaiah, P. P., & Crist, R. M. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-20 · Cited by 865
Ambient Air Pollution and Pregnancy Outcomes: A Review of the Literature
Šrám, R. J., Binková, B., Dejmek, J., & Bobák, M. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.6362 · Cited by 685
Mitochondrial DNA mutations in disease and aging
Wallace, D. C. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20586 · Cited by 622
Mitochondria as a Target of Environmental Toxicants
Meyer, J. N., Leung, M. C. K., Rooney, J. P., Sendoel, A., Hengartner, M. O., Kisby, G. E., & Bess, A. S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft102 · Cited by 587
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
Shock, L. S., Thakkar, P. V., Peterson, E. J., Moran, R. G., & Taylor, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012311108 · Cited by 555

Show all 45 references

Research works printed but not linked: 2

Chistiakov DA, 2014, BioMed Res Int, 2014, Article ID 2384
Feng S, 2012, Mol Med Rep, 6, 125

Sorted by citations

Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
Environmental Influences on the Epigenome: Exposure- Associated DNA Methylation in Human Populations
Martin, E. M., & Fry, R. C. (2018) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040617-014629 · Cited by 658
Association between ambient fine particulate matter and preterm birth or term low birth weight: An updated systematic review and meta-analysis
Li, X., Huang, S., Jiao, A., Yang, X., Yun, J., Wang, Y., Xue, X., Chu, Y., Liu, F., Liu, Y., et al. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.03.055 · Cited by 409
Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339
“[192] reported in utero exposure to PM2.”
Ambient air pollution and pregnancy outcomes: A comprehensive review and identification of environmental public health challenges
Klepac, P., Locatelli, I., Korošec, S., Künzli, N., & Kukec, A. (2018) · Environmental Research · doi:10.1016/j.envres.2018.07.008 · Cited by 358
Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?
Saenen, N. D., Martens, D. S., Neven, K. Y., Alfano, R., Bové, H., Janssen, B. G., Roels, H. A., Plusquin, M., Vrijens, K., & Nawrot, T. S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0688-z · Cited by 267
Self-citation
Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children’s Environmental Health Studies: The Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group
Breton, C. V., Marsit, C. J., Faustman, E. M., Nadeau, K. C., Goodrich, J. M., Dolinoy, D. C., Herbstman, J. B., Holland, N., LaSalle, J. M., Schmidt, R. J., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp595 · Cited by 271
Impact of ambient PM2.5 on adverse birth outcome and potential molecular mechanism
Li, Z., Tang, Y., Song, X., Lazar, L., Li, Z., & Zhao, J. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.10.109 · Cited by 193
Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature
Reddam, A., McLarnan, S. M., & Kupsco, A. J. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00371-7 · Cited by 192
Mitochondrial DNA Methylation and Human Diseases
Stoccoro, A., & Coppedè, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094594 · Cited by 195
Mitochondrial DNA: Epigenetics and environment
Sharma, N., Pasala, M. S., & Prakash, A. (2019) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22319 · Cited by 171
Effects of PM2.5 exposure on reproductive system and its mechanisms
Wang, L., Luo, D., Liu, X., Zhu, J., Wang, F., Li, B., & Li, L. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128436 · Cited by 166
Evidence Suggesting Absence of Mitochondrial DNA Methylation
Mechta, M., Ingerslev, L. R., Fabre, O., Picard, M., & Barrès, R. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00166 · Cited by 157
Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms
Shukla, A., Bunkar, N., Kumar, R., Bhargava, A., Tiwari, R. R., Chaudhury, K., Goryacheva, I. Y., & Mishra, P. K. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.381 · Cited by 167
Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs
Grevendonk, L., Janssen, B. G., Vanpoucke, C., Lefebvre, W., Hoxha, M., Bollati, V., & Nawrot, T. S. (2016) · Environmental Health · doi:10.1186/s12940-016-0095-2 · Cited by 145
“In contrast, the inverse trend we observed in trimester 3 could mean that the foetus is somewhat protected from maternal-derived ROS or might be the result of an early decrease in the number of mitochondria due to mitophagy [31] with less endogenous ROS formation.”
BackgroundSelf-citation
Particulate air pollution and impaired lung function
Paulin, L. M., & Hansel, N. N. (2016) · F1000Research · doi:10.12688/f1000research.7108.1 · Cited by 138
Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line
Nääv, Å., Erlandsson, L., Isaxon, C., Frostner, E. Å., Ehinger, J. K., Sporre, M. K., Krais, A. M., Strandberg, B., Lundh, T., Elmér, E., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00075 · Cited by 129
Prenatal epigenetics diets play protective roles against environmental pollution
Li, S., Chen, M., Li, Y., & Tollefsbol, T. O. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0659-4 · Cited by 129
Placental Nitrosative Stress and Exposure to Ambient Air Pollution During Gestation: A Population Study
Saenen, N. D., Vrijens, K., Janssen, B. G., Madhloum, N., Peusens, M., Gyselaers, W., Vanpoucke, C., Lefebvre, W., Roels, H. A., & Nawrot, T. S. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww007 · Cited by 112
Self-citation
Mitochondrial toxicity of tobacco smoke and air pollution
Fetterman, J. L., Sammy, M. J., & Ballinger, S. W. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.002 · Cited by 117
Effects of Air Pollution and Blood Mitochondrial DNA Methylation on Markers of Heart Rate Variability
Byun, H., Colicino, E., Trevisi, L., Fan, T., Christiani, D. C., & Baccarelli, A. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003218 · Cited by 111
Self-citation
Cohort Profile: The ENVIRonmental influenceONearly AGEing (ENVIRONAGE): a birth cohort study
Janssen, B. G., Madlhoum, N., Gyselaers, W., Bijnens, E. M., Clemente, D. B. P., Cox, B., Hogervorst, J. G. F., Luyten, L. J., Martens, D. S., Peusens, M., et al. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyw269 · Cited by 113
Self-citation
Decreased Methylation of the Mitochondrial D-Loop Region in Late-Onset Alzheimer’s Disease
Stoccoro, A., Siciliano, G., Migliore, L., & Coppedè, F. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170139 · Cited by 109
Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta
Luyten, L. J., Saenen, N. D., Janssen, B. G., Vrijens, K., Plusquin, M., Roels, H. A., Debacq‐Chainiaux, F., & Nawrot, T. S. (2018) · Environmental Research · doi:10.1016/j.envres.2018.03.025 · Cited by 112
Self-citation
Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach
Tsamou, M., Vrijens, K., Madhloum, N., Lefebvre, W., Vanpoucke, C., & Nawrot, T. S. (2018) · Epigenetics · doi:10.1080/15592294.2016.1155012 · Cited by 107
Self-citation
Particulate matter exposure shapes DNA methylation through the lifespan
Ferrari, L., Carugno, M., & Bollati, V. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0726-x · Cited by 107
Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression
Breton, C. V., Song, A., Xiao, J., Kim, S., Mehta, H. H., Wan, J., Yen, K., Sioutas, C., Lurmann, F. W., Xue, S., et al. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.04.001 · Cited by 108
Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIR ON AGE Cohort
Saenen, N. D., Vrijens, K., Janssen, B. G., Roels, H. A., Neven, K. Y., Vanden Berghe, W., Gyselaers, W., Vanpoucke, C., Lefebvre, W., De Boever, P., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp38 · Cited by 104
Self-citation
Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health
Ladd‐Acosta, C., Feinberg, J. I., Brown, S. C., Lurmann, F., Croen, L., Hertz‐Picciotto, I., Newschaffer, C. J., Feinberg, A. P., Fallin, M. D., & Volk, H. E. (2019) · Environment International · doi:10.1016/j.envint.2019.02.028 · Cited by 101
Exposure to ambient air pollution in the first 1000 days of life and alterations in the DNA methylome and telomere length in children: A systematic review
Isaevska, E., Moccia, C., Asta, F., Cibella, F., Gagliardi, L., Ronfani, L., Rusconi, F., Stazi, M. A., & Richiardi, L. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110504 · Cited by 100
Mitochondrial Dysfunction as a Hallmark of Environmental Injury
Tête, A., Brial, F., Benoit, L., Koual, M., Tomkiewicz, C., Kim, M. J., Blanc, É., Coumoul, X., & Bortoli, S. (2021) · Cells · doi:10.3390/cells11010110 · Cited by 99
DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology
Saini, S. K., Mangalhara, K. C., Prakasam, G., & Bamezai, R. N. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-01743-y · Cited by 98
Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study
Eze, I. C., Jeong, A., Schaffner, E., Rezwan, F. I., Ghantous, A., Foraster, M., Vienneau, D., Kronenberg, F., Herceg, Z., Vineis, P., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6174 · Cited by 89
Maternal residential proximity to major roadways, birth weight, and placental DNA methylation
Kingsley, S. L., Eliot, M. N., Whitsel, E. A., Huang, Y.-T., Kelsey, K. T., Marsit, C. J., & Wellenius, G. A. (2016) · Environment International · doi:10.1016/j.envint.2016.03.020 · Cited by 88
Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility
Ghazi, T., Naidoo, P., Naidoo, R. N., & Chuturgoon, A. A. (2021) · Cells · doi:10.3390/cells10113025 · Cited by 92
Pre‐natal brain development as a target for urban air pollution
Sunyer, J., & Dadvand, P. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13226 · Cited by 83
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries
Jia, L., Li, J., He, B., Jia, Y., Niu, Y., Wang, C., & Zhao, R. (2016) · Scientific Reports · doi:10.1038/srep19436 · Cited by 82
Fetal growth and air pollution - A study on ultrasound and birth measures
Malmqvist, E., Liew, Z., Källén, K., Rignell‐Hydbom, A., Rittner, R., Rylander, L., & Ritz, B. R. (2016) · Environmental Research · doi:10.1016/j.envres.2016.09.017 · Cited by 74
The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review)
Alfano, R., Herceg, Z., Nawrot, T. S., Chadeau‐Hyam, M., Ghantous, A., & Plusquin, M. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0218-8 · Cited by 78
Self-citation
A Scoping Review on the Characteristics of Human Exposome Studies
Haddad, N., Andrianou, X. D., & Makris, K. C. (2019) · Current Pollution Reports · doi:10.1007/s40726-019-00130-7 · Cited by 79
Mitoepigenetics and Neurodegenerative Diseases
Coppedè, F., & Stoccoro, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00086 · Cited by 73
Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma
Fang, L., Sun, Q., & Roth, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030757 · Cited by 71
The Respiratory Risks of Ambient/Outdoor Air Pollution
Adamkiewicz, G., Liddie, J. M., & Gaffin, J. M. (2020) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2020.08.013 · Cited by 79
Developmental programming of mitochondrial biology: a conceptual framework and review
Gyllenhammer, L. E., Entringer, S., Buß, C., & Wadhwa, P. D. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2713 · Cited by 75
Wildfire Smoke Exposure during Pregnancy: A Review of Potential Mechanisms of Placental Toxicity, Impact on Obstetric Outcomes, and Strategies to Reduce Exposure
Basilio, E., Chen, R., Fernandez, A. C., Padula, A. M., Robinson, J. F., & Gaw, S. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192113727 · Cited by 70
Prenatal Nitrate Exposure and Childhood Asthma. Influence of Maternal Prenatal Stress and Fetal Sex
Bose, S., Chiu, Y.-H. M., Hsu, H. L., Di, Q., Rosa, M. J., Lee, A., Kloog, I., Wilson, A., Schwartz, J. D., Wright, R. O., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201702-0421oc · Cited by 69
Technical adequacy of bisulfite sequencing and pyrosequencing for detection of mitochondrial DNA methylation: Sources and avoidance of false-positive detection
Owa, C., Poulin, M. L., Yan, L., & Shioda, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192722 · Cited by 68
The effect of prenatal temperature and PM2.5 exposure on birthweight: Weekly windows of exposure throughout the pregnancy
Yitshak‐Sade, M., Kloog, I., Schwartz, J. D., Novack, V., Erez, O., & Just, A. C. (2021) · Environment International · doi:10.1016/j.envint.2021.106588 · Cited by 68
Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight
Janssen, B. G., Gyselaers, W., Byun, H., Roels, H. A., Cuypers, A., Baccarelli, A., & Nawrot, T. S. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-016-1113-4 · Cited by 63
Self-citation
Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency
Novielli, C., Mandò, C., Tabano, S. M., Anelli, G. M., Fontana, L., Antonazzo, P. G. M., Miozzo, M. R., & Cetin, I. (2017) · Placenta · doi:10.1016/j.placenta.2017.05.008 · Cited by 63
The Mitochondrion as Potential Interface in Early-Life Stress Brain Programming
Hoffmann, A., & Spengler, D. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00306 · Cited by 69
Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways: YUE et al.
Yue, C., Ji, C., Zhang, H., Zhang, L. W., Tong, J., Jiang, Y., & Chen, T. (2017) · Environmental Toxicology · doi:10.1002/tox.22448 · Cited by 58
Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis
Stoccoro, A., Smith, A. R., Mosca, L., Marocchi, A., Gerardi, F., Lunetta, C., Cereda, C., Gagliardi, S., Lunnon, K., Migliore, L., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00933-2 · Cited by 57
Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort
Brunst, K. J., Tignor, N. L., Just, A. C., Liu, Z., Lin, X., Hacker, M. R., Enlow, M. B., Wright, R. O., Wang, P., Baccarelli, A., et al. (2018) · Epigenetics · doi:10.1080/15592294.2018.1497387 · Cited by 57
Self-citation
Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution
Ding, R., Jin, Y., Liu, X., Ye, H., Zhu, Z., Zhang, Y., Wang, T., & Xu, Y. (2017) · Scientific Reports · doi:10.1038/srep43737 · Cited by 55
The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
Dabravolski, S. A., Khotina, V. A., Sukhorukov, V. N., Kalmykov, V. A., Михалева, Л. М., & Orekhov, A. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020952 · Cited by 56
Mitochondrial Epigenetics and Environmental Exposure
Lambertini, L., & Byun, H. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0103-2 · Cited by 51
Self-citation
Occupational exposure to particles and mitochondrial DNA - relevance for blood pressure
Xu, Y., Li, H., Hedmer, M., Hossain, M. B., Tinnerberg, H., Bröberg, K., & Albin, M. C. (2017) · Environmental Health · doi:10.1186/s12940-017-0234-4 · Cited by 50
Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
Cantarella, C. D., Ragusa, D., Giammanco, M., & Tosi, S. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0560-8 · Cited by 52
Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity
Corsi, S., Iodice, S., Vigna, L., Çayır, A., Mathers, J. C., Bollati, V., & Byun, H. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00825-5 · Cited by 52
Self-citation
Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors
Vos, S., Nawrot, T. S., Martens, D. S., Byun, H., & Janssen, B. G. (2020) · Epigenetics · doi:10.1080/15592294.2020.1790923 · Cited by 50
Self-citation
Prenatal PM2.5 exposure and vitamin D–associated early persistent atopic dermatitis via placental methylation
Yang, S., Lee, S., Lee, S., Kim, H., Kim, H., Kim, J., Lim, H., Park, M. J., Cho, H., Yoon, J., et al. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.09.008 · Cited by 46
Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies
Devall, M. A. M., Roubroeks, J. A. Y., Mill, J. S., Weedon, M. N., & Lunnon, K. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.013 · Cited by 46
The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases
Ruano, C. S. M., Miralles, F., Méhats, C., & Vaiman, D. (2022) · Antioxidants · doi:10.3390/antiox11010106 · Cited by 47
Genetics of the human placenta: implications for toxicokinetics
Gundacker, C., Neesen, J., Straka, E., Ellinger, I., Dolznig, H., & Hengstschläger, M. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1816-6 · Cited by 44
Exposure to landscape fire smoke reduced birthweight in low- and middle-income countries: findings from a siblings-matched case-control study
Li, J., Guan, T., Guo, Q., Geng, G., Wang, H., Guo, F., Li, J., & Xue, T. (2021) · eLife · doi:10.7554/elife.69298 · Cited by 44
Mitochondrial D-Loop Region Methylation and Copy Number in Peripheral Blood DNA of Parkinson’s Disease Patients
Stoccoro, A., Smith, A. R., Baldacci, F., Gamba, C. D., Gerfo, A. L., Ceravolo, R., Lunnon, K., Migliore, L., & Coppedè, F. (2021) · Genes · doi:10.3390/genes12050720 · Cited by 39
Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)
Fukunaga, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126634 · Cited by 41
Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: Genetic and epigenetic factors.
Lapp, H., Ahmed, S., Moore, C. L., & Hunter, R. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.01.011 · Cited by 35
Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples
Bozack, A. K., Colicino, E., Just, A. C., Wright, R. O., Baccarelli, A., Wright, R. J., & Lee, A. (2021) · Epigenetics · doi:10.1080/15592294.2021.1985300 · Cited by 39
Self-citation
Maternal exposure to ambient fine particulate matter and risk of premature rupture of membranes in Wuhan, Central China: a cohort study
Wang, K., Tian, Y., Zheng, H., Shan, S., Zhao, X., & Liu, C. (2019) · Environmental Health · doi:10.1186/s12940-019-0534-y · Cited by 37
Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage
Scarpato, R., Testi, S., Colosimo, V., García‐Crespo, C., Micheli, C., Azzarà, A., Tozzi, M. G., & Ghirri, P. (2019) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2019.108295 · Cited by 36
Maternal smoking during pregnancy is associated with mitochondrial DNA methylation
Armstrong, D. A., Green, B. B., Blair, B. A., Guerin, D. J., Litzky, J. F., Chavan, N. R., Pearson, K. J., & Marsit, C. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvw020 · Cited by 36
Cell-free circulating mitochondrial DNA: An emerging biomarker for airborne particulate matter associated with cardiovascular diseases
Rehman, A., Kumari, R., Kamthan, A., Tiwari, R. R., Srivastava, R. K., van der Westhuizen, F. H., & Mishra, P. K. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.083 · Cited by 37
Mitoepigenetics: The different shades of grey
Ghosh, S., Singh, K. K., Sengupta, S., & Scaria, V. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.09.003 · Cited by 38
Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study
Janssen, B. G., Byun, H., Roels, H. A., Gyselaers, W., Penders, J., Baccarelli, A., & Nawrot, T. S. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0366-y · Cited by 37
Self-citation
The impact of prenatal insults on the human placental epigenome: A systematic review
Palma‐Gudiel, H., Cirera, F., Crispi, F., Eixarch, E., & Fañanás, L. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.01.001 · Cited by 37
Prenatal Ambient Particulate Matter Exposure and Longitudinal Weight Growth Trajectories in Early Childhood
Rosofsky, A., Fabian, M. P., de Cuba, S. E., Sandel, M. T., Coleman, S. M., Levy, J. I., Coull, B. A., Hart, J. E., & Zanobetti, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17041444 · Cited by 37
Mitochondrial Epigenetics and Environmental Health: Making a Case for Endocrine Disrupting Chemicals
Zhou, Z., Goodrich, J. M., & Strakovsky, R. S. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa129 · Cited by 38
Placental gene networks at the interface between maternal PM2.5 exposure early in gestation and reduced infant birthweight
Deyssenroth, M. A., Rosa, M. J., Eliot, M., Kelsey, K. T., Kloog, I., Schwartz, J. D., Wellenius, G. A., Peng, S., Hao, K., Marsit, C. J., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111342 · Cited by 40
Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures
Wāng, Y. (2024) · Environment International · doi:10.1016/j.envint.2024.109193 · Cited by 35
Gender Differences in the Outcome of Offspring Prenatally Exposed to Drugs of Abuse
Traccis, F., Frau, R., & Melis, M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00072 · Cited by 37
Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood
Breton, C. V., Gao, L., Yao, J., Siegmund, K. D., Lurmann, F. W., & Gilliland, F. D. (2016) · Current Zoology · doi:10.1093/eep/dvw005 · Cited by 33
Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort
Winckelmans, E., Vrijens, K., Tsamou, M., Janssen, B. G., Saenen, N. D., Roels, H. A., Kleinjans, J. C. S., Lefebvre, W., Vanpoucke, C., de Kok, T. M. C. M., et al. (2017) · Environmental Health · doi:10.1186/s12940-017-0264-y · Cited by 33
Self-citation
Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA†
Jia, L., Zeng, Y., Hu, Y., Liu, J., Yin, C., Niu, Y., Wang, C., Li, J., Jia, Y., Hong, J., et al. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy238 · Cited by 35
Impact of air pollution on low birth weight in Spain: An approach to a National Level Study
Arroyo, V., Díaz, J., Salvador, P., & Linares, C. (2019) · Environmental Research · doi:10.1016/j.envres.2019.01.030 · Cited by 33
The effect of paternal methyl-group donor intake on offspring DNA methylation and birth weight
Pauwels, S., Truijen, I., Ghosh, M., Duca, R. C., Langie, S. A. S., Bekaert, B., Freson, K., Huybrechts, I., Koppen, G., Devlieger, R., et al. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000046 · Cited by 34
Exposure to Metals, Pesticides, and Air Pollutants: Focus on Resulting DNA Methylation Changes in Neurodegenerative Diseases
Stoccoro, A., & Coppedè, F. (2024) · Biomolecules · doi:10.3390/biom14111366 · Cited by 33
Association of maternal exposure to ambient particulate pollution with incident spontaneous pregnancy loss
Wang, H., Li, J., Liu, H., Guo, F., Xue, T., Guan, T., & Li, J. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112653 · Cited by 31
Lung function growth trajectories in non-asthmatic children aged 4–9 in relation to prenatal exposure to airborne particulate matter and polycyclic aromatic hydrocarbons – Krakow birth cohort study
Majewska, R., Pac, A., Mróz, E., Spengler, J. D., Camann, D., Mrozek‐Budzyn, D., Sowa, A., Jacek, R., Wheelock, K., & Perera, F. P. (2018) · Environmental Research · doi:10.1016/j.envres.2018.05.037 · Cited by 29
Maternal exposure to fine particulate matter and the risk of fetal distress
Liu, H., Liao, J., Jiang, Y., Zhang, B., Yu, H., Kang, J., Hu, C., Li, Y., & Xu, S. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.068 · Cited by 29
Neurodevelopmental toxicity induced by airborne particulate matter
Shang, M., Tang, M. X., & Xue, Y. (2022) · Journal of Applied Toxicology · doi:10.1002/jat.4382 · Cited by 30
Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review
Desai, G. S., Chu, L., Guo, Y., Myneni, A. A., & Mu, L. (2017) · Biomarkers · doi:10.1080/1354750x.2017.1339294 · Cited by 29
Temporal variability of global DNA methylation and hydroxymethylation in buccal cells of healthy adults: Association with air pollution
Nys, S. D., Duca, R. C., Nawrot, T. S., Hoet, P., MEERBEEK, B. V., LANDUYT, K. L. V., & Godderis, L. (2017) · Environment International · doi:10.1016/j.envint.2017.11.002 · Cited by 29
Self-citation
Epigenome-Wide Cross-Tissue Predictive Modeling and Comparison of Cord Blood and Placental Methylation in a Birth Cohort
Carli, M. M. D., Baccarelli, A., Trevisi, L., Pantic, I., Brennan, K. J. M., Hacker, M. R., Loudon, H., Brunst, K. J., Wright, R. O., Wright, R. J., et al. (2017) · Epigenomics · doi:10.2217/epi-2016-0109 · Cited by 27
Self-citation
Chronic sun exposure is associated with distinct histone acetylation changes in human skin
Ding, S., Chen, J., Zeng, Q., Lu, J., Tan, L., Guo, A., Kang, J., Yang, S., Xiang, Y., Zuo, C., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16129 · Cited by 27
Effects of prenatal exposure to particulate air pollution on newborn mitochondrial DNA copy number
Hu, C., Sheng, X., Li, Y., Xia, W., Zhang, B., Chen, X., Xing, Y., Li, X., Liu, H., Sun, X., et al. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126592 · Cited by 25
Prenatal exposures and DNA methylation in newborns: a pilot study in Durban, South Africa
Goodrich, J. M., Reddy, P., Naidoo, R. N., Asharam, K., Batterman, S., & Dolinoy, D. C. (2016) · Environmental Science Processes & Impacts · doi:10.1039/c6em00074f · Cited by 24
Glomerular function in relation to fine airborne particulate matter in a representative population sample
Feng, Y.-M., Thijs, L., Zhang, Z.-Y., Bijnens, E., Yang, W.-Y., Wei, F.-F., Janssen, B., Nawrot, T., & Staessen, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-94136-1 · Cited by 18
Self-citation
Mitochondrial DNA oxidation, methylation, and copy number alterations in major and bipolar depression
Ceylan, D., Karaçiçek, B., Tufekci, K., Aksahin, I. C., Şenol, Ş. H., & Genç, Ş. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1304660 · Cited by 24

Authors: Janssen, B. G., Byun, H.-M., Gyselaers, W., Lefebvre, W., Baccarelli, A. A., & Nawrot, T. S.
Affiliations: Hasselt University (BE)
Harvard University (US)
Ziekenhuis Oost-Limburg (BE)
Flemish Institute for Technological Research (BE)
Corresponding author: Nawrot, Tim S
ORCID: Janssen, Bram G
Byun, Hyang-Min
Gyselaers, Wilfried
Lefebvre, Wouter
Baccarelli, Andrea A
Nawrot, Tim S
Venue: Epigenetics
Publisher: Informa UK Limited
Published: 2015-05-21
Volume: 10
Issue: 6
Pages: 536-544
ISSN: 1559-2294 (ISSN-L)
1559-2308
DOI: 10.1080/15592294.2015.1048412
PMC: PMC4623402
OpenAlex: W1828742533
Cited by: 187
References: 45
Citations by year: 2026: 7 · 2025: 11 · 2024: 17 · 2023: 13 · 2022: 23 · 2021: 18 · 2020: 18 · 2019: 15 · 2018: 23 · 2017: 25 · 2016: 15 · 2015: 2
FWCI: 9.40
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Epigenetics (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Document Server@UHasselt (UHasselt) (submittedVersion, cc-by-nc)
Lirias (submittedVersion)
Funders: National Institute of Environmental Health Sciences (R21ES022694, R01ES021733, R01ES021357)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: PM2.5 exposure, airborne particulate matter, mtDNA content, mitophagy, MT-RNR1, D-loop, oxidative stress, ENVIRONAGE birth cohort, mediation analysis
MeSH terms: Environmental Exposure, Female, Humans, Infant, Newborn, Male, Mitochondria, Placenta, Pregnancy, RNA, Ribosomal, Oxidative Stress, DNA Methylation, Epigenesis, Genetic, Particulate Matter, Genome, Mitochondrial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIR ON AGE birth cohort study

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks