The DOI matches its Crossref record; 90 of the 94 references it cites were found in a registry or an index.
Social scaffolding of human amygdala-mPFCcircuit development
Open accessAbstract
Strong evidence indicates that reciprocal connections between the amygdala and the medial prefrontal cortex (mPFC) support fundamental aspects of emotional behavior in adulthood. However, this circuitry is slow to develop in humans, exhibiting immaturity in childhood. The argument is made that the development of this circuitry in humans is intimately associated with caregiving, such that parental availability during childhood provides important and enduring scaffolding of neuroaffective processes that ultimately form of the nature of the adult phenotype.
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“A comprehensive set of literature reviews (9, 32, 78, 83–86) details the hypothesis that early environmental factors, e.g., early caregiving or the lack thereof, modulate the timing and course of emotional development.”
From The Stress Acceleration Hypothesis of Nightmares (2017) · cites this paper as [86]
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Cites
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Cognitive Recovery in Socially Deprived Young Children: The Bucharest Early Intervention Project
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“The rate of developmental improvement is notable such that across many domains of behavior, PI children begin to more closely resemble children without a history of caregiving adversity (Nelson et al., 2007; Rutter, 1998).”
Background
Research works printed but not linked: 8
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- 10.1111/jcpp.1989.30.issue-1 · DOI
- 10.1111/apa.1994.83.issue-s397 · DOI
- 10.1002/dev.v57.1 · DOI
- 10.1111/nyas.1972.193.issue-1 · DOI
- 10.1111/jcpp.2013.55.issue-1 · DOI
- 10.1111/desc.2011.14.issue-2 · DOI
- Tottenham N., 2010, Frontiers in Human Neuroscience, 3, 1
Cited by
Sorted by citations
Childhood Adversity and Neural Development: A Systematic Review
McLaughlin, K. A., Weissman, D., & Bitrán, D. (2019) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-121318-084950 · Cited by 892
Early life stress and development: potential mechanisms for adverse outcomes
Smith, K. E., & Pollak, S. D. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09337-y · Cited by 500
The effects of social isolation stress and discrimination on mental health
Brandt, L., Liu, S., Heim, C. C., & Heinz, A. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02178-4 · Cited by 549
Stress and adolescence: vulnerability and opportunity during a sensitive window of development
Sisk, L. M., & Gee, D. G. (2022) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2021.10.005 · Cited by 374
Smith, K. E., & Pollak, S. D. (2020) · Perspectives on Psychological Science · doi:10.1177/1745691620920725 · Cited by 379
Metadata
- Authors
- Tottenham, N.
- Affiliations
- Columbia University (US)
- Corresponding author
- Tottenham, Nim
- ORCID
- Tottenham, Nim
- Venue
- Social Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2015-09-03
- Volume
- 10
- Issue
- 5
- Pages
- 489-499
- ISSN
- 1747-0919 (ISSN-L)
- 1747-0927
- PMC
- PMC4890612
- OpenAlex
- W1892826918
- Cited by
- 112
- References
- 94
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 7 · 2020: 33 · 2019: 10 · 2018: 4 · 2017: 8 · 2016: 3
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Social Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Division of Behavioral and Cognitive Sciences (BCS-1439258)
- NIMH (R01MH091864)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, medial prefrontal cortex, social scaffolding, caregiving, parental availability, emotional development, brain development, childhood, emotional behavior
- MeSH terms
- Adolescent, Adult, Amygdala, Animals, Emotions, Humans, Magnetic Resonance Imaging, Parents, Social Behavior, Prefrontal Cortex
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