Cited by 113Child and Adolescent Psychosocial and Emotional DevelopmentNeuroendocrine regulation and behaviorNeural and Behavioral Psychology Studies

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Social scaffolding of human amygdala-mPFCcircuit development

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Tottenham, Nim·2015·Social Neuroscience

DOI 10.1080/17470919.2015.1087424PMC PMC4890612

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Abstract

Strong evidence indicates that reciprocal connections between the amygdala and the medial prefrontal cortex (mPFC) support fundamental aspects of emotional behavior in adulthood. However, this circuitry is slow to develop in humans, exhibiting immaturity in childhood. The argument is made that the development of this circuitry in humans is intimately associated with caregiving, such that parental availability during childhood provides important and enduring scaffolding of neuroaffective processes that ultimately form of the nature of the adult phenotype.

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“The rate of developmental improvement is notable such that across many domains of behavior, PI children begin to more closely resemble children without a history of caregiving adversity (Nelson et al., 2007; Rutter, 1998).”
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Ayyash, S., Sunderji, A., Gallant, H. D., Hall, A., Davis, A. D., Pokhvisneva, I., Meaney, M. J., Silveira, P. P., Sassi, R. B., & Hall, G. B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1066373 · Cited by 1
Serotonin transporter (5-HTT) gene network moderates the impact of prenatal maternal adversity on orbitofrontal cortical thickness in middle childhood
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Introduction
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0001 · Cited by 1
Central Neural Circuits Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0005 · Cited by 1
Alloparental Behavior and Paternal Behavior in Nonhuman Mammals
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Emotion Regulation Strategy Usage Explains Links Between Institutional Caregiving and Elevated Internalizing SymptomsPreprint
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Molecular Specification of Claustro-Amygdalar and Paleocortical Neurons and ConnectivityPreprint
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A sudden and lasting separation from a parent can permanently alter brain development
Dębiec, J. (2018) · doi:10.64628/aai.knau6nft3 · Cited by 1
Evolutionary Perspectives on the Parental Brain
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Anxiety Reduction and Maternal Aggression in Postpartum Nonhuman Mammals
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Development of the Parental Brain in Nonhuman Mammals
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Development of the Parental Brain in Humans
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Brain Mechanisms Regulating Maternal Behavior in Nonhuman Mammals
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Neuroscientific Approaches to the Study of Self and Social Emotion Regulation During Development
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An epigenetic mechanism for differential maturation of amygdala-prefrontal connectivity in childhood socio-emotional developmentPreprint
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Influence of Parenting on Child Emotion Regulation
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Preface
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Copyright Page
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003

Authors: Tottenham, N.
Affiliations: Columbia University (US)
Corresponding author: Tottenham, Nim
ORCID: Tottenham, Nim
Venue: Social Neuroscience
Publisher: Informa UK Limited
Published: 2015-09-03
Volume: 10
Issue: 5
Pages: 489-499
ISSN: 1747-0919 (ISSN-L)
1747-0927
DOI: 10.1080/17470919.2015.1087424
PMC: PMC4890612
OpenAlex: W1892826918
Cited by: 112
References: 94
Citations by year: 2026: 6 · 2025: 12 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 7 · 2020: 33 · 2019: 10 · 2018: 4 · 2017: 8 · 2016: 3
FWCI: 0.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Social Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Division of Behavioral and Cognitive Sciences (BCS-1439258)
NIMH (R01MH091864)
Topics: Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: amygdala, medial prefrontal cortex, social scaffolding, caregiving, parental availability, emotional development, brain development, childhood, emotional behavior
MeSH terms: Adolescent, Adult, Amygdala, Animals, Emotions, Humans, Magnetic Resonance Imaging, Parents, Social Behavior, Prefrontal Cortex

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Social scaffolding of human amygdala-mPFCcircuit development

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