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The journey of islet cell transplantation and future development
Open accessAbstract
Intraportal islet transplantation has proven to be efficacious in preventing severe hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes. Multiple islet infusions are often required to achieve and maintain insulin independence. Many challenges remain in clinical islet transplantation, including substantial islet cell loss early and late after islet infusion. Contributions to graft loss include the instant blood-mediated inflammatory reaction, potent host auto- and alloimmune responses, and beta cell toxicity from immunosuppressive agents. Protective strategies are being tested to circumvent several of these events including exploration of alternative transplantation sites, stem cell-derived insulin producing cell therapies, co-transplantation with mesenchymal stem cells or exploration of novel immune protective agents. Herein, we provide a brief introduction and history of islet cell transplantation, limitations associated with this procedure and methods to alleviate islet cell loss as a means to improve engraftment outcomes.
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“To date, however, these alternative sites have yet to lead to improved transplant outcomes when compared to portal vein infusion in humans.149”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [149]
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“These alternative sites may also potentially circumvent the intense IBMIR response that is observed with portal vein infusion.149”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [149]
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Cited by
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Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges
Sneddon, J. B., Tang, Q., Stock, P. G., Bluestone, J. A., Roy, S., Desai, T. A., & Hebrok, M. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.016 · Cited by 252
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Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210
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Metadata
- Authors
- Gamble, A., Pepper, A. R., Bruni, A., & Shapiro, A. M. J.
- Affiliations
- University of Alberta (CA)
- Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada
- Corresponding author
- Shapiro, A. M. James
- Venue
- Islets
- Publisher
- Informa UK Limited
- Published
- 2018-02-05
- Volume
- 10
- Issue
- 2
- Pages
- 80-94
- ISSN
- 1938-2014 (ISSN-L)
- 1938-2022
- PMC
- PMC5895174
- OpenAlex
- W2791423015
- Cited by
- 171
- References
- 133
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 14 · 2023: 29 · 2022: 30 · 2021: 32 · 2020: 32 · 2019: 9 · 2018: 2
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Islets (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Research Institute Foundation
- Stem Cell Network
- Alberta Innovates
- National Institutes of Health
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- islet transplantation, type 1 diabetes, graft loss, islet engraftment, hypoglycemia prevention, insulin independence, islet autoimmunity, immunosuppressants, beta-cell toxicity, intraportal transplantation, mesenchymal stem cells, immunoprotection
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Graft Survival, Humans, Islets of Langerhans, Autoimmunity, Islets of Langerhans Transplantation, Neovascularization, Physiologic, Tissue and Organ Harvesting, Pluripotent Stem Cells, Mesenchymal Stem Cell Transplantation
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