Cited by 171Pancreatic function and diabetesDiabetes and associated disordersDiabetes Management and Research

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The journey of islet cell transplantation and future development

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Gamble, Anissa, Pepper, Andrew R., Bruni, Antonio, Shapiro, A. M. James·2018·Islets

DOI 10.1080/19382014.2018.1428511PMC PMC5895174

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Abstract

Intraportal islet transplantation has proven to be efficacious in preventing severe hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes. Multiple islet infusions are often required to achieve and maintain insulin independence. Many challenges remain in clinical islet transplantation, including substantial islet cell loss early and late after islet infusion. Contributions to graft loss include the instant blood-mediated inflammatory reaction, potent host auto- and alloimmune responses, and beta cell toxicity from immunosuppressive agents. Protective strategies are being tested to circumvent several of these events including exploration of alternative transplantation sites, stem cell-derived insulin producing cell therapies, co-transplantation with mesenchymal stem cells or exploration of novel immune protective agents. Herein, we provide a brief introduction and history of islet cell transplantation, limitations associated with this procedure and methods to alleviate islet cell loss as a means to improve engraftment outcomes.

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See all 171

Authors: Gamble, A., Pepper, A. R., Bruni, A., & Shapiro, A. M. J.
Affiliations: University of Alberta (CA)
Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada
Corresponding author: Shapiro, A. M. James
ORCID: Gamble, Anissa
Pepper, Andrew R.
Bruni, Antonio
Shapiro, A. M. James
Venue: Islets
Publisher: Informa UK Limited
Published: 2018-02-05
Volume: 10
Issue: 2
Pages: 80-94
ISSN: 1938-2014 (ISSN-L)
1938-2022
DOI: 10.1080/19382014.2018.1428511
PMC: PMC5895174
OpenAlex: W2791423015
Cited by: 171
References: 133
Citations by year: 2026: 7 · 2025: 16 · 2024: 14 · 2023: 29 · 2022: 30 · 2021: 32 · 2020: 32 · 2019: 9 · 2018: 2
FWCI: 4.17
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Islets (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Diabetes Research Institute Foundation
Stem Cell Network
Alberta Innovates
National Institutes of Health
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: islet transplantation, type 1 diabetes, graft loss, islet engraftment, hypoglycemia prevention, insulin independence, islet autoimmunity, immunosuppressants, beta-cell toxicity, intraportal transplantation, mesenchymal stem cells, immunoprotection
MeSH terms: Animals, Diabetes Mellitus, Type 1, Graft Survival, Humans, Islets of Langerhans, Autoimmunity, Islets of Langerhans Transplantation, Neovascularization, Physiologic, Tissue and Organ Harvesting, Pluripotent Stem Cells, Mesenchymal Stem Cell Transplantation

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