The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Inhibiting extracellular vesicles formation and release: a review of EV inhibitors
Open accessAbstract
It is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell‐to‐cell communication, both in physiological and pathological conditions. Once outside the cell, these vesicles are termed extracellular vesicles (EVs). The cellular origin (cell type), subcellular origin (through the endosomal pathway or pinched from the cell membrane) and content (what proteins, glycoproteins, lipids, nucleic acids, metabolites) are transported by the EVs, and their size, all seem to be contributing factors to their overall heterogeneity. Efforts are being invested into attempting to block the release of subpopulations of EVs or, indeed, all EVs. Some such studies are focussed on investigating EV inhibitors as research tools; others are interested in the longerterm potential of using such inhibitors in pathological conditions such as cancer. This review, intended to be of relevance to both researchers already well established in the EV field and newcomers to this field, provides an outline of the compounds that have been most extensively studied for this purpose, their proposed mechanisms of actions and the findings of these studies.
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Self-citationShedding light on the cell biology of extracellular vesicles
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Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
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Rab27a and Rab27b control different steps of the exosome secretion pathway
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Cited by
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663
Self-citationRegulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Lee, Y. J., Shin, K. J., & Chae, Y. C. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01209-y · Cited by 427
Immune evasion through mitochondrial transfer in the tumour microenvironment
Ikeda, H., Kawase, K., Nishi, T., Watanabe, T., Takenaga, K., Inozume, T., Ishino, T., Aki, S., Lin, J., Kawashima, S., et al. (2025) · Nature · doi:10.1038/s41586-024-08439-0 · Cited by 330
Tsiapalis, D., & O’Driscoll, L. (2020) · Cells · doi:10.3390/cells9040991 · Cited by 313
Self-citationDynamic mapping of proteome trafficking within and between living cells by TransitID
Qin, W., Cheah, J. S., Xu, C., Messing, J., Freibaum, B. D., Boeynaems, S., Taylor, J. P., Udeshi, N. D., Carr, S. A., & Ting, A. Y. (2023) · Cell · doi:10.1016/j.cell.2023.05.044 · Cited by 160
Metadata
- Authors
- Catalano, M., & O'Driscoll, L.
- Venue
- Journal of Extracellular Vesicles
- Publisher
- Wiley
- Published
- 2019-12-19
- Volume
- 9
- Issue
- 1
- Pages
- 1703244-1703244
- ISSN
- 2001-3078 (ISSN-L)
- OpenAlex
- W2995667982
- Cited by
- 658
- References
- 99
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- gold
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