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Coordination of AMPA receptor trafficking by Rab GTPases

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Hausser, Angelika, Schlett, Katalin·2019·Small GTPases
DOI 10.1080/21541248.2017.1337546PMC PMC6748377
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Abstract

Synaptic connections in the brain are continuously weakened or strengthened in response to changes in neuronal activity. This process, known as synaptic plasticity, is the cellular basis for learning and memory, and is thought to be altered in several neuronal disorders. An important aspect of synaptic plasticity is the tightly controlled trafficking and synaptic targeting of the AMPA-type glutamate receptors, which are the major mediators of fast excitatory transmission in the brain. This review addresses the role of Rab GTPases in AMPA receptor trafficking in neurons under basal conditions and during activity-induced synaptic plasticity, especially during long-term potentiation (LTP) and long-term depression (LTD). We highlight the importance of the tight spatio-temporal control of Rab activity and suggest that this is critical for proper neuronal functions. We also discuss how abnormal AMPA receptor trafficking and malfunctioning of Rabs can lead to neurologic disorders or memory problems.

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Cited by

Sorted by citations

Authors
Hausser, A., & Schlett, K.
Affiliations
  • University of Stuttgart (DE)
  • Eötvös Loránd University (HU)
Corresponding author
  • Hausser, Angelika
  • Schlett, Katalin
ORCID
Venue
Small GTPases
Publisher
Informa UK Limited
Published
2017-07-05
Volume
10
Issue
6
Pages
419-432
ISSN
  • 2154-1248 (ISSN-L)
  • 2154-1256
DOI
10.1080/21541248.2017.1337546
PMC
PMC6748377
OpenAlex
W2720580067
Cited by
45
References
6
Citations by year
2026: 1 · 2025: 9 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 1
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Small GTPases (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
AMPA receptor trafficking, Rab GTPases, synaptic plasticity, long-term potentiation, long-term depression, synaptic targeting, excitatory synaptic transmission, memory disorders
MeSH terms
Animals, Neuronal Plasticity, Neurons, Receptors, AMPA, rab GTP-Binding Proteins, Protein Transport

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