The DOI matches its Crossref record, with a small difference in title or year; 55 of the 55 references it cites were found in a registry or an index.
Fast-cycling Rho GTPases
Abstract
The Rho GTPases were discovered more than 30 years ago, and they were for a long time considered to follow simple cycling between GDP-bound and GTP-bound conformations, as for the Ras subfamily of small GTPases. The Rho GTPases consist of 20 members, but at least 10 of these do not follow this classical GTPase cycle. Thus, based on their kinetic properties, these Rho GTPases can instead be classified as atypical. Some of these atypical Rho GTPases do not hydrolyze GTP, and some have significantly increased intrinsic GDP/GTP exchange activity. This review focuses on this latter category of atypical Rho GTPases, the so-called 'fast-cycling' Rho GTPases. The different members of these fast-cycling atypical Rho GTPases are described in more detail here, along with their potential regulatory mechanisms. Finally, some insights are provided into the involvement of the atypical Rho GTPases in human pathologies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“By contrast, the GTPase defective atypical Rho-family members, including Rnd1, Rnd2, Rnd3, RhoBTB1, RhoBTB2 and RhoH, do not possess the conserved Gly12, Ala59 and Gln61 compared with Cdc42 (Table 3) [4,13].”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [13]
In the citing paper
“It also contains a shorter Rho insert region that is more similar to classical Rho-family proteins but is GTPase defective because conserved residues corresponding to Gly12, Ala59 and Gln61 (Ras numbering) are absent (Table 3).”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Physiological concentrations of purines and pyrimidines
Traut, T. W. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00928361 · Cited by 1,867
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Krauthammer, M., Kong, Y., Ha, B. H., Evans, P., Bacchiocchi, A., McCusker, J. P., Cheng, E., Davis, M. J., Goh, G., Choi, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2359 · Cited by 1,191
Regulating Rho GTPases and their regulators
Hodge, R. G., & Ridley, A. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.67 · Cited by 872
A novel ras-related gene family
Madaule, P., & Axel, R. (1985) · Cell · doi:10.1016/0092-8674(85)90058-3 · Cited by 502
Evolution of the Rho Family of Ras-Like GTPases in Eukaryotes
Boureux, A., Vignal, E., Faure, S., & Fort, P. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msl145 · Cited by 447
Rho GTPases have diverse effects on the organization of the actin filament system
Aspenström, P., Fransson, Å., & Saras, J. (2004) · Biochemical Journal · doi:10.1042/bj20031041 · Cited by 437
Self-citationNobes, C. D., Lauritzen, I., Mattéi, M., Paris, S., Hall, A., & Chardin, P. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.187 · Cited by 362
Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360
The Rho Family GTPase Rif Induces Filopodia through mDia2
Pellegrin, S., & Mellor, H. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.011 · Cited by 289
Cited by
Müller, P. M., Rademacher, J., Bagshaw, R. D., Wortmann, C., Barth, C., van Unen, J., Alp, K. M., Giudice, G., Eccles, R. L., Heinrich, L. E., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0488-x · Cited by 253
RHO GTPases: from new partners to complex immune syndromes
El Masri, R., & Delon, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00500-7 · Cited by 131
The Role of RhoH in TCR Signalling and Its Involvement in Diseases
Ahmad Mokhtar, A. M., Hashim, I. F., Mohd Zaini Makhtar, M., Salikin, N. H., & Amin-Nordin, S. (2021) · Cells · doi:10.3390/cells10040950 · Cited by 25
Metadata
- Authors
- Aspenström, P.
- Affiliations
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg 16, Box 280, SE, Stockholm, Sweden
- Venue
- Small GTPases
- Publisher
- Informa UK Limited
- Published
- 2018-01-29
- Volume
- 11
- Issue
- 4
- Pages
- 248-255
- ISSN
- 2154-1248
- 2154-1256
- Cited by
- 46
- References
- 55
- Language
- en
- Funders
- Swedish cancer society (2014/0644)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fast-cycling Rho GTPases. https://app.cochat.ai/papers/10.1080/21541248.2017.1391365
- The paper
- Aspenström, P. (2020). Fast-cycling Rho GTPases. Small GTPases. https://doi.org/10.1080/21541248.2017.1391365
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
