Cited by 277TGF-β signaling in diseasesMechanisms of cancer metastasisCancer Cells and Metastasis

The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.

Transforming growth factor-β: A therapeutic target for cancer

Open access
Haque, Sulsal, Morris, John C.·2017·Human Vaccines & Immunotherapeutics

Abstract

Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immunity. It has a paradoxical role in cancer. In the early stages it inhibits cellular transformation and prevents cancer progression. In later stages TGF-β plays a key role in promoting tumor progression through mainly 3 mechanisms: facilitating epithelial to mesenchymal transition, stimulating angiogenesis and inducing immunosuppression. As a result of its opposing tumor promoting and tumor suppressive abilities, TGF-β and its pathway has represented potential opportunities for drug development and several therapies targeting the TGF-β pathway have been identified. This review focuses on identifying the mechanisms through which TGF-β is involved in tumorigenesis and current therapeutics that are under development.

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Crossref · 10.1080/21645515.2017.1327107

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  1. 10.1016/j.ejca.2015.07.035 · DOI · Paper page
  2. 10.1172/JCI0215234 · DOI

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Metadata

Authors
Haque, S., & Morris, J. C.
Affiliations
University of Cincinnati (US)
Corresponding author
Morris, John C.
Venue
Human Vaccines & Immunotherapeutics
Published
2017-06-16
Volume
13
Issue
8
Pages
1741-1750
ISSN
  • 2164-5515 (ISSN-L)
  • 2164-554X
OpenAlex
W2621206827
Cited by
276
References
145
Citations by year
2026: 19 · 2025: 33 · 2024: 30 · 2023: 49 · 2022: 36 · 2021: 44 · 2020: 33 · 2019: 23 · 2018: 6 · 2017: 2
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • Human Vaccines & Immunotherapeutics (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
TGF-beta, TGF-beta signaling, tumor progression, epithelial-mesenchymal transition, tumor angiogenesis, immunosuppression, tumor suppression, drug development, TGF-β inhibitors
MeSH terms
Animals, Antibodies, Monoclonal, Antineoplastic Agents, Cell Differentiation, Humans, Neoplasms, Neovascularization, Pathologic, Signal Transduction, Transforming Growth Factor beta, Oligonucleotides, Antisense, Apoptosis, Mice, Epithelial-Mesenchymal Transition

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