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Transforming growth factor-β: A therapeutic target for cancer
Open accessAbstract
Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immunity. It has a paradoxical role in cancer. In the early stages it inhibits cellular transformation and prevents cancer progression. In later stages TGF-β plays a key role in promoting tumor progression through mainly 3 mechanisms: facilitating epithelial to mesenchymal transition, stimulating angiogenesis and inducing immunosuppression. As a result of its opposing tumor promoting and tumor suppressive abilities, TGF-β and its pathway has represented potential opportunities for drug development and several therapies targeting the TGF-β pathway have been identified. This review focuses on identifying the mechanisms through which TGF-β is involved in tumorigenesis and current therapeutics that are under development.
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Metadata
- Authors
- Haque, S., & Morris, J. C.
- Affiliations
- University of Cincinnati (US)
- Corresponding author
- Morris, John C.
- Venue
- Human Vaccines & Immunotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2017-06-16
- Volume
- 13
- Issue
- 8
- Pages
- 1741-1750
- ISSN
- 2164-5515 (ISSN-L)
- 2164-554X
- PMC
- PMC5557219
- OpenAlex
- W2621206827
- Cited by
- 276
- References
- 145
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 30 · 2023: 49 · 2022: 36 · 2021: 44 · 2020: 33 · 2019: 23 · 2018: 6 · 2017: 2
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Vaccines & Immunotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- TGF-beta, TGF-beta signaling, tumor progression, epithelial-mesenchymal transition, tumor angiogenesis, immunosuppression, tumor suppression, drug development, TGF-β inhibitors
- MeSH terms
- Animals, Antibodies, Monoclonal, Antineoplastic Agents, Cell Differentiation, Humans, Neoplasms, Neovascularization, Pathologic, Signal Transduction, Transforming Growth Factor beta, Oligonucleotides, Antisense, Apoptosis, Mice, Epithelial-Mesenchymal Transition
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