Cited by 277TGF-β signaling in diseasesMechanisms of cancer metastasisCancer Cells and Metastasis

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Transforming growth factor-β: A therapeutic target for cancer

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Haque, Sulsal, Morris, John C.·2017·Human Vaccines & Immunotherapeutics

DOI 10.1080/21645515.2017.1327107PMC PMC5557219

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Abstract

Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immunity. It has a paradoxical role in cancer. In the early stages it inhibits cellular transformation and prevents cancer progression. In later stages TGF-β plays a key role in promoting tumor progression through mainly 3 mechanisms: facilitating epithelial to mesenchymal transition, stimulating angiogenesis and inducing immunosuppression. As a result of its opposing tumor promoting and tumor suppressive abilities, TGF-β and its pathway has represented potential opportunities for drug development and several therapies targeting the TGF-β pathway have been identified. This review focuses on identifying the mechanisms through which TGF-β is involved in tumorigenesis and current therapeutics that are under development.

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Authors: Haque, S., & Morris, J. C.
Affiliations: University of Cincinnati (US)
Corresponding author: Morris, John C.
ORCID: Haque, Sulsal
Morris, John C.
Venue: Human Vaccines & Immunotherapeutics
Publisher: Informa UK Limited
Published: 2017-06-16
Volume: 13
Issue: 8
Pages: 1741-1750
ISSN: 2164-5515 (ISSN-L)
2164-554X
DOI: 10.1080/21645515.2017.1327107
PMC: PMC5557219
OpenAlex: W2621206827
Cited by: 276
References: 145
Citations by year: 2026: 19 · 2025: 33 · 2024: 30 · 2023: 49 · 2022: 36 · 2021: 44 · 2020: 33 · 2019: 23 · 2018: 6 · 2017: 2
FWCI: 1.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Human Vaccines & Immunotherapeutics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: TGF-beta, TGF-beta signaling, tumor progression, epithelial-mesenchymal transition, tumor angiogenesis, immunosuppression, tumor suppression, drug development, TGF-β inhibitors
MeSH terms: Animals, Antibodies, Monoclonal, Antineoplastic Agents, Cell Differentiation, Humans, Neoplasms, Neovascularization, Pathologic, Signal Transduction, Transforming Growth Factor beta, Oligonucleotides, Antisense, Apoptosis, Mice, Epithelial-Mesenchymal Transition

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Transforming growth factor-β: A therapeutic target for cancer

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