The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Plant derived edible nanoparticles as a new therapeutic approach against diseases
Open accessAbstract
In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as extracellular messengers to mediate cell-cell communication in a manner similar to the exosomes secreted by mammalian cells. Notably, such nanoparticles are edible. Moreover, given the proper origin and cargo, plant derived edible nanoparticles could function in interspecies communication and may serve as natural therapeutics against a variety of diseases. In addition, nanoparticles made of plant-derived lipids may be used to efficiently deliver specific drugs. Plant derived edible nanoparticles could be more easily scaled up for mass production, compared to synthetic nanoparticles. In this review, we discuss recent significant developments pertaining to plant derived edible nanoparticles and provide insight into the use of plants as a bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles.
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“Even plant-derived exosomes have been characterized and shown to have structures similar to mammalian exosomes to mediate plant–animal intercellular communication [5].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [5]
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1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
RetractedIsolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162
Functional delivery of viral miRNAs via exosomes
Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Würdinger, T., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,672
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643
Exosomal-like vesicles are present in human blood plasma
Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348
Quantitative and stoichiometric analysis of the microRNA content of exosomes
Chevillet, J. R., Kang, Q., Ruf, I. K., Briggs, H., Vojtech, L. N., Hughes, S. M., Cheng, H. H., Arroyo, J. D., Meredith, E. K., Gallichotte, E. N., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408301111 · Cited by 1,137
Research works printed but not linked: 5
- Tanaka Y, 2013, Cancer-Am Cancer Soc, 119, 1159
- Taylor DD, 2015, Methods, 1046, 00092
- Thery C, 2006, Curr Protoc Cell Biol
- 10.1016/j.ceb.2004.06.003 · DOI · Paper page
- Zhang MZ, 2014, Nanotechnology, 25
Cited by
Sorted by citations
Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323
Zhang, M., Viennois, É., Prasad, M. A., Zhang, Y., Wang, L., Zhang, Z., Han, M. K., Xiao, B., Xu, C., Srinivasan, S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.018 · Cited by 1,071
Self-citationExosomes in cancer development, metastasis, and immunity
Zhang, L., & Yu, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.004 · Cited by 870
Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth
Cao, M., Yan, H., Han, X., Weng, L., Qin, W. D., Sun, X., Lu, W., Wei, Q., Ye, J., Cai, X., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0817-4 · Cited by 571
Zhang, M., Xiao, B., Wang, H., Han, M. K., Zhang, Z., Viennois, É., Xu, C., & Merlin, D. (2016) · Molecular Therapy · doi:10.1038/mt.2016.159 · Cited by 463
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Metadata
- Authors
- Zhang, M., Viennois, E., Xu, C., & Merlin, D.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Zhang, Mingzhen
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2016-02-11
- Volume
- 4
- Issue
- 2
- Pages
- e1134415
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- PMC
- PMC4910829
- OpenAlex
- W2340580991
- Cited by
- 311
- References
- 78
- Citations by year
- 2026: 34 · 2025: 32 · 2024: 43 · 2023: 44 · 2022: 46 · 2021: 48 · 2020: 27 · 2019: 14 · 2018: 13 · 2017: 5 · 2016: 5
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Tissue Barriers (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Crohn's and Colitis Foundation (329228)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071594)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- extracellular vesicles, microRNA, bioactive lipids, plant proteins, interspecies communication, drug delivery, plant-based therapeutics
- MeSH terms
- Administration, Oral, Animals, Humans, Plant Extracts, Nanoparticles, Exosomes
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