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Cited by 18Neurogenesis and neuroplasticity mechanismsEpigenetics and DNA MethylationNeuroinflammation and Neurodegeneration Mechanisms

Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood

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Noguchi, Hirofumi, Kimura, Ayaka, Murao, Naoya, Namihira, Masakazu, Nakashima, Kinichi·2016·Neurogenesis
DOI 10.1080/23262133.2016.1232679PMC PMC5063063
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Abstract

Despite recent advances in our understanding of epigenetic regulation of central nervous system development, little is known regarding the effects of epigenetic dysregulation on neurogenesis and brain function in adulthood. In the present study, we show that prenatal deletion of DNA methyltransferase 1 (Dnmt1) in neural stem cells results in impaired neurogenesis as well as increases in inflammatory features (e.g., elevated glial fibrillary acidic protein [GFAP] expression in astrocytes and increased numbers of microglia) in the adult mouse brain. Moreover, these mice exhibited anxiety-like behavior during an open-field test. These findings suggest that Dnmt1 plays a critical role in regulating neurogenesis and behavior in the developing brain and into adulthood.

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Authors
Noguchi, H., Kimura, A., Murao, N., Namihira, M., & Nakashima, K.
Affiliations
  • Kyushu University (JP)
  • National Institute of Advanced Industrial Science and Technology (JP)
Corresponding author
Namihira, Masakazu
ORCID
Venue
Neurogenesis
Publisher
Informa UK Limited
Published
2016-01
Volume
3
Issue
1
Pages
e1232679
ISSN
  • 2326-2125 (ISSN-L)
  • 2326-2133
DOI
10.1080/23262133.2016.1232679
PMC
PMC5063063
OpenAlex
W2516292783
Cited by
18
References
44
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1
FWCI
0.85
Type
journal article
Language
en
Open access
Locations
  • Neurogenesis (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Agency for Medical Research and Development (CREST)
  • Japan Society for the Promotion of Science (13J09870, 16H06524, CREST, 26430083)
  • Core Research for Evolutional Science and Technology
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
DNMT1, neural stem cells, anxiety-like behavior, epigenetic regulation, glial fibrillary acidic protein, astrocytes, microglia, neuroinflammation

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