Neurodegenerative disease and adult neurogenesis
Abstract
The generation and cell death of newly generated cells have critical roles in brain development and maintenance in the embryonic and adult brain. Alterations in these processes are also seen in neurodegenerative diseases. Genes that are key players in neurodegenerative diseases (α-synuclein, presenilin-1, tau, huntingtin) are also physiologically involved in modulating brain plasticity. Interestingly, in some neurodegenerative diseases, the specific alterations in neurogenic areas such as the dentate gyrus and subventricular zone/olfactory bulb system parallel the early or premotor symptoms that are seen in the early stages of these diseases, such as depression, anxiety or olfactory dysfunction. We will review the modulation of neurogenesis in animal models and human brains of Parkinson's disease, Huntington's disease and Alzheimer's disease.
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The observed increase in neurons potentially reflects the aberrant placement of neurons.
“and potentially reflects the aberrant placement of neurons [47]”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [47]
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“The observed increase in neurons indirectly supports the aforementioned evidence of increased neurogenesis and potentially reflects the aberrant placement of neurons [47], although we did not measure neurogenesis directly here as this was beyond the scope of the study.”
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- Authors
- Winner, B., Kohl, Z., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Universitätsklinikum Erlangen (DE)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2011-03
- Volume
- 33
- Issue
- 6
- Pages
- 1139-1151
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2100211448
- Cited by
- 405
- References
- 13
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 19 · 2020: 29 · 2019: 15 · 2018: 24 · 2017: 26 · 2016: 40 · 2015: 37 · 2014: 45 · 2013: 42 · 2012: 46
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, neurodegenerative diseases, dentate gyrus, subventricular zone, olfactory bulb, neuroplasticity, Parkinson's disease, Huntington's disease, Alzheimer's disease, alpha-synuclein, presenilin 1, tau protein, huntingtin, depression, anxiety, olfactory dysfunction, animal models
- MeSH terms
- Animals, Brain, Disease Models, Animal, Humans, Neurodegenerative Diseases, Animals, Genetically Modified, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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