Absence of mutations associated with sulfa resistance in Pneumocystis carinii dihydropteroate synthase gene from non-human primates.
Abstract
The dihydropteroate synthase (DHPS) gene from Pneumocystis carinii isolated from non-human primates was amplified using a polymerase chain reaction (PCR) and sequenced to analyse point mutations associated with sulfa resistance. P. carinii DHPS gene amplification was obtained from eight lung samples from five New World primate species and one Old World primate species. None of the animals had been exposed to sulfa drugs and only the wild-type P. carinii DHPS sequence at codons 55 and 57 was observed. These data support the hypothesis that high rates of DHPS mutants in P. carinii f. sp. hominis have arisen with increased use of sulfa drugs for P. carinii pneumonia prophylaxis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DHPS gene mutations have not been found in other mammalian Pneumocystis species that have not been exposed to sulfa medications.
“Furthermore, DHPS gene mutations have not been found in other mammalian Pneumocystis species that have not been exposed to sulfa medications (18,27).”
From Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance (2004) · cites this paper as [27]
Cites
Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 39,119 · see citing works
Helweg-Larsen, J., Benfield, T. L., Eugen-Olsen, J., Lundgren, J. D., & Lundgren, B. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03320-6 · Cited by 274 · see citing works
Dihydropteroate synthase polymorphisms in Pneumocystis carinii.
Lane, B. R., Ast, J. C., Hossler, P. A., Mindell, D. P., Bartlett, M. S., Smith, J. W., & Meshnick, S. R. (1997) · Journal of Infectious Diseases · doi:10.1093/infdis/175.2.482 · Cited by 176 · see citing works
Kazanjian, P., Locke, A. B., Hossler, P. A., Lane, B. R., Bartlett, M. S., Smith, J. W., Cannon, M., & Meshnick, S. R. (1998) · AIDS · doi:10.1097/00002030-199808000-00009 · Cited by 171 · see citing works
Huang, L., Beard, C. B., Creasman, J., Levy, D., Duchin, J. S., Lee, S., Pieniazek, N., Carter, J. L., del Rio, C., Rimland, D., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315824 · Cited by 149 · see citing works
Demanche, C., Berthelemy, M., Petit, T., Polack, B., Wakefield, A. E., Dei‐Cas, E., & Guillot, J. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.6.2126-2133.2001 · Cited by 124 · see citing works
Self-citationNavin, T. R., Beard, C. B., Huang, L., del Rio, C., Lee, S., Pieniazek, N. J., Carter, J. L., Le, T., Hightower, A., & Rimland, D. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05705-1 · Cited by 117 · see citing works
Mei, Q., Gurunathan, S., Masur, H., & Kovacs, J. A. (1998) · The Lancet · doi:10.1016/s0140-6736(05)77687-x · Cited by 108 · see citing works
Genetic divergence at the SODA locus of six different formae speciales of Pneumocystis carinii
Aliouat‐Denis, C., Mazars, E., Guyot, K., Ödberg-Ferragut, C., Viscogliosi, É., Dei‐Cas, E., & Wakefield, A. E. (2000) · Medical Mycology · doi:10.1080/714030952 · Cited by 56 · see citing works
Self-citationLd, S., Lacube, P., Latouche, S., Kac, G., Mayaud, C. M., Marteau, M., Jl, P., Maury, É., Guillot, J., & Roux, P. (1999) · PubMed · Cited by 36 · see citing works
Self-citationDurand-Joly, I., Wakefield, A. E., Palmer, R. J., Aliouat‐Denis, C., Creusy, C., Fleurisse, L., Ricard, I., Gut, J., & Dei‐Cas, E. (2000) · Medical Mycology · doi:10.1080/714030897 · Cited by 35 · see citing works
Self-citationExperimental inoculation of immunosuppressed owl monkeys with Pneumocystis carinii f. sp. hominis.
Cb, B., Jennings, V. M., Teague, W., Jl, C., Mabry, J., Moura, H., VISVESVARA, G. S., Collins, W. E., & Navin, T. (1999) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
HIV-Associated <i>Pneumocystis</i> Pneumonia
Huang, L., Cattamanchi, A., Davis, J. L., Boon, S. D., Kovacs, J., Meshnick, S., Miller, R. F., Walzer, P. D., Worodria, W., & Masur, H. (2011) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201009-062wr · Cited by 191 · see citing works
Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance
Huang, L., Crothers, K., Atzori, C., Benfield, T., Miller, R., Rabodonirina, M., & Helweg-Larsen, J. (2004) · Emerging Infectious Diseases · doi:10.3201/eid1010.030994 · Cited by 131 · see citing works
“Furthermore, DHPS gene mutations have not been found in other mammalian Pneumocystis species that have not been exposed to sulfa medications (18,27).”
BackgroundIliades, P., Meshnick, S. R., & Macreadie, I. G. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2617-2623.2004 · Cited by 48 · see citing works
Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials
Swarbrick, J., Iliades, P., Simpson, J. S., & Macreadie, I. G. (2008) · The Open Enzyme Inhibition Journal · doi:10.2174/1874940200801010012 · Cited by 41 · see citing works
Mutations in the Pneumocystis jirovecii DHPS Gene Confer Cross-Resistance to Sulfa Drugs
Iliades, P., Meshnick, S. R., & Macreadie, I. G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.741-748.2005 · Cited by 38 · see citing works
Pneumocystis jiroveci. Applied molecular microbiology, epidemiology and diagnosis.
Helweg‐Larsen, J. (2004) · PubMed · Cited by 31 · see citing works
Iliades, P., Meshnick, S. R., & Macreadie, I. G. (2005) · Microbial Drug Resistance · doi:10.1089/mdr.2005.11.1 · Cited by 17 · see citing works
Iliades, P., Walker, D. J., Castelli, L. A., Satchell, J. F., Meshnick, S. R., & Macreadie, I. G. (2004) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2004.08.006 · Cited by 12 · see citing works
CROTHERS, K., HUANG, L., MORRIS, A., FOX, M., GRONER, G., TURNER, J. R., MERRIFIELD, C., EISER, S., FRIEDLY, J., GRAVARI, E., et al. (2003) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2003.tb00648.x · Cited by 12 · see citing works
Drug Resistance in Pneumocystis jirovecii
Helweg‐Larsen, J., Benfield, T., Kovacs, J. A., & Masur, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-47266-9_22 · Cited by 2 · see citing works
Jönsson, M. E. (2005) · Uppsala University Publications (Uppsala University) · Cited by 1 · see citing works
Drug Resistance in Pneumocystis jirovecii
Helweg‐Larsen, J., Benfield, T., Kovacs, J. A., & Masur, H. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-595-8_22
Dihydropteroate Synthase Gene Mutations in Pneumocystis and
Resistance, S., Huang, L., Crothers, K. A., Atzori, C., Benfield, T., Miller, R. F., Rabodonirina, M., & Helweg‐Larsen, J. (2004)
- Authors
- Demanche, C., Guillot, J., Berthelemy, M., Petit, T., Roux, P., & Wakefield, A. E.
- Affiliations
- École Nationale Vétérinaire d'Alfort (FR)
- Venue
- Medical Mycology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06-01
- Volume
- 40
- Issue
- 3
- Pages
- 315-318
- ISSN
- 0268-1218 (ISSN-L)
- 1369-3786
- OpenAlex
- W2141328445
- Cited by
- 13
- References
- 12
- Citations by year
- 2017: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Mycology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Pneumocystis carinii, dihydropteroate synthase, point mutations, non-human primates, New World primates, Old World primates, Pneumocystis carinii pneumonia, drug resistance
- MeSH terms
- Amino Acid Sequence, Animals, Animals, Zoo, Antifungal Agents, Cebidae, Cercopithecidae, Dihydropteroate Synthase, France, Genes, Fungal, Lung, Molecular Sequence Data, Monkey Diseases, Pneumocystis, Pneumonia, Pneumocystis, Strepsirhini, Trimethoprim, Sulfamethoxazole Drug Combination, Sequence Alignment, Point Mutation, Drug Resistance, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
