CoChat
Sign Up
Cited by 156Eating Disorders and BehaviorsSchizophrenia research and treatmentNutrition, Health and Food Behavior

Olanzapine therapy in anorexia nervosa: psychobiological effects

Open access
Brambilla, Francesca, Garcia, Cristina Segura, Fassino, Secondo, Daga, Giovanni Abbate, Favaro, Angela, Santonastaso, Paolo, Ramaciotti, Carla, Bondi, Emilia +3 more·2007·International Clinical Psychopharmacology
DOI 10.1097/yic.0b013e328080ca31
Open this paper in CoChat — free account

Abstract

Dopamine impairments occur in anorexia nervosa. The aim of this study was to see whether treatment with the atypical dopamine antagonist antipsychotic olanzapine improves the disorder. Thirty anorexics, 18 restricted and 12 bingeing-purging, underwent a 3-month course of cognitive behavioral therapy, plus at random and double-blinded oral olanzapine (2.5 mg for 1 month, 5 mg for 2 months) in half and oral placebo in the other half of them. BMI, psychopathological aspects (eating disorder inventory, Hamilton Rating Scale, Buss-Durkee Rating Scale, Yale Brown Cornell for Eating Disorders Rating Scale, temperament-character inventory), and homovanillic acid blood concentrations for dopamine secretion, were monitored at baseline and then monthly during the trial. At the end of the trial BMI, total eating disorder inventory, total Yale Brown Cornell for Eating Disorders Rating Scale, Buss-Durkee Rating Scale, Hamilton Rating Scale scores and in olanzapine-treated patients the subitems of eating disorder inventory ineffectiveness and maturity fear, of Buss-Durkee Rating Scale direct aggressiveness, of temperament-characteristic inventory persistence had improved significantly. When stratified for anorexia nervosa subtype, BMI changes were significant among anorexia nervosa bingeing-purging patient, 'depression' (Hamilton Rating Scale) and 'direct aggressiveness' (Buss-Durkee Rating Scale) among anorexia nervosa bingeing-purging patients, 'persistence' (temprerament-characteristic inventory), among anorexics restricted patients, with a trend toward significance for obsessivity-compulsivity (Yale Brown Cornell for Eating Disorders Rating Scale). homovanilic acid blood levels increased significantly in the cognitive behavioral therapy+olanzapine group. No correlations were observed between homovanilic acid concentrations and psychopathological parameters. The pharmacological treatment can significantly improve specific aspects of anorexia nervosa.

Integrity signals

Registry

Crossref · 10.1097/yic.0b013e328080ca31

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

2 of the 78 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Brambilla, F., Garcia, C. S., Fassino, S., Daga, G. A., Favaro, A., Santonastaso, P., Ramaciotti, C., Bondi, E., Mellado, C., Borriello, R., & Monteleone, P.
Affiliations
University of Pisa (IT)
ORCID
Venue
International Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-07
Volume
22
Issue
4
Pages
197-204
ISSN
0268-1315 (ISSN-L)
DOI
10.1097/yic.0b013e328080ca31
OpenAlex
W2045510386
Cited by
156
References
78
Citations by year
2026: 3 · 2025: 14 · 2024: 8 · 2023: 9 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 1 · 2015: 12 · 2014: 7 · 2013: 9 · 2012: 10
FWCI
10.51
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • International Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
anorexia nervosa, olanzapine, atypical antipsychotics, dopamine antagonists, homovanillic acid, cognitive behavioral therapy, eating disorder symptoms, temperament, aggression, depression, obsessive-compulsive symptoms
MeSH terms
Olanzapine, Adult, Anorexia Nervosa, Benzodiazepines, Combined Modality Therapy, Double-Blind Method, Female, Homovanillic Acid, Humans, Antipsychotic Agents, Cognitive Behavioral Therapy, Dopamine Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review