Cited by 142Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

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The yeast cell-wall salvage pathway

Popolo, L., Gualtieri, T., Ragni, E.·2001·Medical Mycology

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Abstract

The integrity of the cell wall depends on the synthesis and correct assembly of its individual components. Several environmental factors, such as temperature up-shift, treatments with mating factors or with specific cell wall-perturbing drugs, or genetic factors, such as inactivation of cell wall-related genes (for example FKS1 or GAS1) can impair construction of the cell wall. As the cell wall is essential for preserving the osmotic integrity of the cell, several responses are triggered in response to cell-wall damage. This review focuses on the activation of salvage pathways that guarantee cell survival through remodeling of the extracellular matrix. These researches have useful implication for the study of similar pathways in human fungal pathogens, and for the evaluation of the efficacy of new antifungal drugs.

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Authors: Popolo, L., Gualtieri, T., & Ragni, E.
Affiliations: University of Milan (IT)
Corresponding author: Popolo, L.
ORCID: Popolo, L.
Ragni, E.
Venue: Medical Mycology
Publisher: Oxford University Press (OUP)
Published: 2001-01
Volume: 39
Issue: 1
Pages: 111-121
ISSN: 0268-1218 (ISSN-L)
1369-3786
1460-2709
DOI: 10.1080/mmy.39.1.111.121
OpenAlex: W2162102216
Cited by: 142
References: 51
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 7
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Locations: Medical Mycology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: yeast cell wall, salvage pathway, cell wall damage, cell wall remodeling, extracellular matrix, FKS1, GAS1, mating factor, antifungal drug targets, fungal pathogens, Saccharomyces cerevisiae
MeSH terms: Cell Wall, Fungal Proteins, Fungi, Protein Kinase C, Signal Transduction, Calcineurin, MAP Kinase Signaling System

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The yeast cell-wall salvage pathway

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