Loss of the Plasma Membrane-Bound Protein Gas1p in Saccharomyces cerevisiae Results in the Release of β1,3-Glucan into the Medium and Induces a Compensation Mechanism To Ensure Cell Wall Integrity

Ram, Arthur F. J.; Kapteyn, Johan C.; Montijn, Roy C.; Caro, L. Heleen P.; Douwes, Jeroen E.; Baginsky, Walter; Mazur, Paul; van den Ende, Herman; Klis, Frans M.

doi:10.1128/jb.180.6.1418-1424.1998

Cited by 200Fungal and yeast genetics researchAntifungal resistance and susceptibilityPolysaccharides and Plant Cell Walls

Loss of the Plasma Membrane-Bound Protein Gas1p in Saccharomyces cerevisiae Results in the Release of β1,3-Glucan into the Medium and Induces a Compensation Mechanism To Ensure Cell Wall Integrity

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Ram, Arthur F. J., Kapteyn, Johan C., Montijn, Roy C., Caro, L. Heleen P., Douwes, Jeroen E., Baginsky, Walter, Mazur, Paul, van den Ende, Herman +1 more·1998·Journal of Bacteriology

DOI 10.1128/jb.180.6.1418-1424.1998PMC PMC107039

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Abstract

Deletion of GAS1/GGP1/CWH52 results in a lower β-glucan content of the cell wall and swollen, more spherical cells (L. Popolo, M. Vai, E. Gatti, S. Porello, P. Bonfante, R. Balestrini, and L. Alberghina, J. Bacteriol. 175:1879–1885, 1993; A. F. J. Ram, S. S. C. Brekelmans, L. J. W. M. Oehlen, and F. M. Klis, FEBS Lett. 358:165–170, 1995). We show here that gas1 Δ cells release β1,3-glucan into the medium. Western analysis of the medium proteins with β1,3-glucan- and β1,6-glucan-specific antibodies showed further that at least some of the released β1,3-glucan was linked to protein as part of a β1,3-glucan–β1,6-glucan–protein complex. These data indicate that Gas1p might play a role in the retention of β1,3-glucan and/or β-glucosylated proteins. Interestingly, the defective incorporation of β1,3-glucan in the cell wall was accompanied by an increase in chitin and mannan content in the cell wall, an enhanced expression of cell wall protein 1 (Cwp1p), and an increase in β1,3-glucan synthase activity, probably caused by the induced expression of Fks2p. It is proposed that the cell wall weakening caused by the loss of Gas1p induces a set of compensatory reactions to ensure cell integrity.

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Chs3p is the major compensatory chitin synthase both in cell wall stress and HWS in fungi.
“Our functional analyses demonstrate that CHS3 is crucial during hyphal growth in the absence of Phr1p and support the notion that Chs3p is the major compensatory chitin synthase both in cell wall stress and HWS in fungi [21, 28, 47, 62, 63].”
From Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking β(1,3)-glucan remodeling (2016) · cites this paper as [63]
Our functional analyses demonstrate that CHS3 is crucial during hyphal growth in the absence of Phr1p.
“Our functional analyses demonstrate that CHS3 is crucial during hyphal growth in the absence of Phr1p and support the notion that Chs3p is the major compensatory chitin synthase both in cell wall stress and HWS in fungi [21, 28, 47, 62, 63].”
From Genomic and functional analyses unveil the response to hyphal wall stress in Candida albicans cells lacking β(1,3)-glucan remodeling (2016) · cites this paper as [63]

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Functional analysis of Candida albicans GPI-anchored proteins: Roles in cell wall integrity and caspofungin sensitivity
Plaine, A., Walker, L., Da Costa, G., Mora-Montes, H. M., McKinnon, A., Gow, N. A. R., Gaillardin, C., Munro, C. A., & Richard, M. L. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.08.003 · Cited by 238 · see citing works
Cell wall dynamics in yeast
Smits, G. J., Kapteyn, J. C., ENDE, H. V. D., & Klis, F. M. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80061-7 · Cited by 227 · see citing works
Self-citation
Comprehensive Proteomic Analysis of Saccharomyces cerevisiae Cell Walls
Yin, Q. Y., de Groot, P. W. J., Dekker, H. L., de Jong, L., Klis, F. M., & de Koster, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500334200 · Cited by 193 · see citing works
Self-citation
Low external pH induces HOG1‐dependent changes in the organization of the Saccharomyces cerevisiae cell wall
Kapteyn, J. C., ter Riet, B., Vink, E., Blad, S., de Nobel, H., ENDE, H. V. D., & Klis, F. M. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02242.x · Cited by 195 · see citing works
Self-citation
PHR1 and PHR2 of Candida albicans Encode Putative Glycosidases Required for Proper Cross-Linking of β-1,3- and β-1,6-Glucans
Fonzi, W. A. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.22.7070-7079.1999 · Cited by 193 · see citing works
Chitin synthesis in human pathogenic fungi
Munro, C. A., & Gow, N. A. R. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.41.53 · Cited by 191 · see citing works
The Gas1 glycoprotein, a putative wall polymer cross-linker
Popolo, L., & Vai, M. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00138-x · Cited by 185 · see citing works
Altered extent of cross-linking of beta1,6-glucosylated mannoproteins to chitin in Saccharomyces cerevisiae mutants with reduced cell wall beta1,3-glucan content
Kapteyn, J. C., Ram, A. F. J., Groos, E. M., KOLLÁR, R., Montijn, R. C., ENDE, H. V. D., Llobell, A., Cabib, E., & Klis, F. M. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.20.6279-6284.1997 · Cited by 181 · see citing works
Self-citation
The fungal cell wall as a target for the development of new antifungal therapies
Cortés, J. C. G., Curto, M.-Á., Carvalho, V. S. D., Pérez, P., & Ribas, J. C. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.008 · Cited by 172 · see citing works
The contribution of the O‐glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild‐type cells and β1,6‐glucan‐deficient mutants
Kapteyn, J. C., van Egmond, P., Sievi, E., ENDE, H. V. D., Makarow, M., & Klis, F. M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01320.x · Cited by 168 · see citing works
Self-citation
Analysis of β-1,3-Glucan Assembly in Saccharomyces cerevisiae Using a Synthetic Interaction Network and Altered Sensitivity to Caspofungin
Lesage, G., Sdicu, A.-M., Ménard, P., Shapiro, J., Hussein, S., & Bussey, H. (2004) · Genetics · doi:10.1534/genetics.167.1.35 · Cited by 166 · see citing works
Deletion of GEL2 encoding for a β(1–3)glucanosyltransferase affects morphogenesis and virulence in Aspergillus fumigatus
Mouyna, I., Morelle, W., Vai, M., Monod, M., Léchenne, B., Fontaine, T., Beauvais, A., Sarfati, J., Prévost, M., Henry, C., et al. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04654.x · Cited by 165 · see citing works
A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae
de Groot, P. W. J., Ruíz‐Romero, C., de Aldana, C. R. V., Dueñas, E., Cid, V. J., del Rey, F., Rodríguez-Peña, J. M., Pérez, P., Andel, A., Caubín, J., et al. (2001) · Comparative and Functional Genomics · doi:10.1002/cfg.85 · Cited by 165 · see citing works
Self-citation
Chitin Synthesis in Saccharomyces cerevisiae in Response to Supplementation of Growth Medium withGlucosamine and Cell WallStress
Bulik, D. A., Olczak, M., Lucero, H. A., Osmond, B. C., Robbins, P. W., & Specht, C. A. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.886-900.2003 · Cited by 159 · see citing works
Reciprocal Regulation of Anaerobic and Aerobic Cell Wall Mannoprotein Gene Expression in Saccharomyces cerevisiae
Abramova, N., Sertil, O., Mehta, S., & Lowry, C. V. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.9.2881-2887.2001 · Cited by 157 · see citing works
The transcription factor Con7p is a central regulator of infection‐related morphogenesis in the rice blast fungusMagnaporthe grisea
Odenbach, D., Breth, B., Thines, E., Weber, R. W. S., Anke, H., & Foster, A. J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05643.x · Cited by 155 · see citing works
The cell wall and the response and tolerance to stresses of biotechnological relevance in yeasts
Ribeiro, R. A., Bourbon-Melo, N., & Sá‐Correia, I. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.953479 · Cited by 155 · see citing works
Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)‐anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae
Kitagaki, H., Wu, H., Shimoi, H., & Ito, K. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03244.x · Cited by 143 · see citing works
The yeast cell-wall salvage pathway
Popolo, L., Gualtieri, T., & Ragni, E. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.111.121 · Cited by 142 · see citing works
The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall
Aimanianda, V., Simenel, C., Garnaud, C., Clavaud, C., Tada, R., Barbin, L., Mouyna, I., Heddergott, C., Popolo, L., Ohya, Y., et al. (2017) · mBio · doi:10.1128/mbio.00619-17 · Cited by 135 · see citing works
The cell wall stress response in Aspergillus niger involves increased expression of the glutamine : fructose-6-phosphate amidotransferase-encoding gene (gfaA) and increased deposition of chitin in the cell wall
Ram, A. F. J. (2004) · Microbiology · doi:10.1099/mic.0.27249-0 · Cited by 135 · see citing works
Self-citation
Expression deconvolution: A reinterpretation of DNA microarray data reveals dynamic changes in cell populations
Lü, P., Nakorchevsky, A., & Marcotte, E. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832361100 · Cited by 130 · see citing works
Identification of the MNN2 and MNN5Mannosyltransferases Required for Forming and Extending the Mannose Branches of the Outer Chain Mannans of Saccharomyces cerevisiae
Rayner, J. C., & Munro, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26836 · Cited by 129 · see citing works
AGS3, an α(1–3)glucan synthase gene family member of Aspergillus fumigatus, modulates mycelium growth in the lung of experimentally infected mice
Maubon, D., Park, S., Tanguy, M., Huerre, M., Schmitt, C., Prévost, M., Perlin, D. S., Latgé, J., & Beauvais, A. (2006) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2006.01.006 · Cited by 123 · see citing works
A Refined Method for the Determination of Saccharomyces cerevisiae Cell Wall Composition and β-1,6-Glucan Fine Structure
Magnelli, P. E., Cipollo, J. F., & Abeijón, C. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5473 · Cited by 122 · see citing works
Defects in Protein Glycosylation Cause SHO1-Dependent Activation of a STE12 Signaling Pathway in Yeast
Cullen, P. J., Schultz, J., Horecka, J., Stevenson, B. J., Jigami, Y., & Sprague, G. F. (2000) · Genetics · doi:10.1093/genetics/155.3.1005 · Cited by 118 · see citing works
Msb2 Signaling Mucin Controls Activation of Cek1 Mitogen-Activated Protein Kinase in Candida albicans
Román, E., Cottier, F., Ernst, J. F., & Pla, J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00081-09 · Cited by 113 · see citing works
PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity
Pardo, M. (2004) · Microbiology · doi:10.1099/mic.0.26924-0 · Cited by 107 · see citing works
Involvement of GFA1, which encodes glutamine–fructose‐6‐phosphate amidotransferase, in the activation of the chitin synthesis pathway in response to cell‐wall defects in Saccharomyces cerevisiae
Lagorce, A., Berre, V. L., Aguilar‐Uscanga, B. R., Martin‐Yken, H., Dagkessamanskaia, A., & François, J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2002.02814.x · Cited by 106 · see citing works
A study of the Candida albicans cell wall proteome
Castillo, L., Calvo, E., Martinez, A. I., Ruiz-Herrera, J., Valentín, E., López, J., & Sentandreu, R. (2008) · Proteomics · doi:10.1002/pmic.200800110 · Cited by 107 · see citing works
The role of the cell wall in fungal pathogenesis
Arana, D. M., Prieto, D., Román, E., Nombela, C., Alonso‐Monge, R., & Pla, J. (2009) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00070.x · Cited by 92 · see citing works
Chitin Synthesis in a gas1 Mutant of Saccharomyces cerevisiae
Valdivieso, M.-H., Ferrario, L., Vai, M., Duran, A., & Popolo, L. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.17.4752-4757.2000 · Cited by 89 · see citing works
Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae
García‐Rodríguez, L. J., Trilla, J. A., Castro, C., Valdivieso, M. ‐., Durán, A., & Roncero, C. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01835-4 · Cited by 89 · see citing works
Rho1 has distinct functions in morphogenesis, cell wall biosynthesis and virulence of Fusarium oxysporum
Martínez-Rocha, A. L., Roncero, M. I. G., López-Ramírez, A., Mariné, M., Guarro, J., Martínez‐Cadena, G., & Pietro, A. D. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01130.x · Cited by 85 · see citing works
Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling
Hurtado‐Guerrero, R., Schüttelkopf, A. W., Mouyna, I., Ibrahim, A. F. M., Shepherd, S., Fontaine, T., Latgé, J., & van Aalten, D. M. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807990200 · Cited by 86 · see citing works
Survival in the Presence of Antifungals
Meyer, V., Damveld, R. A., Arentshorst, M., Stahl, U., van den Hondel, C. A. M. J. J., & Ram, A. F. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705856200 · Cited by 85 · see citing works
Self-citation
Nanoscale Effects of Caspofungin against Two Yeast Species, Saccharomyces cerevisiae and Candida albicans
Formosa‐Dague, C., Schiavone, M., Martin‐Yken, H., François, J., Duval, R. E., & Dague, É. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00105-13 · Cited by 84 · see citing works
Mutations in Fks1p affect the cell wall content of β‐1,3‐ and β‐1,6‐glucan in Saccharomyces cerevisiae
Dijkgraaf, G. J. P., Abe, M., Ohya, Y., & Bussey, H. (2002) · Yeast · doi:10.1002/yea.866 · Cited by 85 · see citing works
N-hypermannose glycosylation disruption enhances recombinant protein production by regulating secretory pathway and cell wall integrity in Saccharomyces cerevisiae
Tang, H., Wang, S., Wang, J., Song, M., Xu, M., Zhang, M., Shen, Y., Hou, J., & Bao, X. (2016) · Scientific Reports · doi:10.1038/srep25654 · Cited by 82 · see citing works
The Genetics and Biochemistry of Cell Wall Structure and Synthesis in Neurospora crassa, a Model Filamentous Fungus
Patel, P. K., & Free, S. J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02294 · Cited by 78 · see citing works
PHR1, a pH-regulated gene of Candida albicans encoding a glucan-remodelling enzyme, is required for adhesion and invasion
Calderon, J., Zavrel, M., Ragni, E., Fonzi, W. A., Rupp, S., & Popolo, L. (2010) · Microbiology · doi:10.1099/mic.0.038000-0 · Cited by 72 · see citing works
Genome-Scale Analysis Reveals Sst2 as the Principal Regulator of Mating Pheromone Signaling in the Yeast Saccharomyces cerevisiae
Chasse, S., Flanary, P. L., Parnell, S. C., Hao, N., Cha, J. Y., Siderovski, D. P., & Dohlman, H. G. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.2.330-346.2006 · Cited by 71 · see citing works
The β‐1,3‐glucanosyltransferases (Gels) affect the structure of the rice blast fungal cell wall during appressorium‐mediated plant infection
Samalova, M., Mélida, H., Vilaplana, F., Bulone, V., Soanes, D. M., Talbot, N. J., & Gurr, S. J. (2016) · Cellular Microbiology · doi:10.1111/cmi.12659 · Cited by 71 · see citing works
Yeast adaptive response to acetic acid stress involves structural alterations and increased stiffness of the cell wall
Ribeiro, R. A., Vitorino, M. V., Godinho, C. P., Bourbon-Melo, N., Robalo, T. T., Fernandes, F., Rodrigues, M. S., & Sá‐Correia, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-92069-3 · Cited by 70 · see citing works
Rosemary essential oil and its components 1,8-cineole and α-pinene induce ROS-dependent lethality and ROS-independent virulence inhibition in Candida albicans
Shahina, Z., Homsi, R. A., Price, J. D. W., Whiteway, M. S., Sultana, T., & Dahms, T. E. S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277097 · Cited by 71 · see citing works
Fusarium oxysporum gas1 Encodes a Putative β-1, 3-Glucanosyltransferase Required for Virulence on Tomato Plants
Caracuel, Z., Martínez-Rocha, A. L., Pietro, A. D., Madrid, M. P., & Roncero, M. I. G. (2005) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-18-1140 · Cited by 66 · see citing works
YLL031c Belongs to a Novel Family of Membrane Proteins Involved in the Transfer of Ethanolaminephosphate onto the Core Structure of Glycosylphosphatidylinositol Anchors in Yeast
Flury, I., Benachour, A., & Conzelmann, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003844200 · Cited by 65 · see citing works
Effects of Yeast Cell-Wall Characteristics on 4-Ethylphenol Sorption Capacity in Model Wine
Pradelles, R., Alexandre, H., Ortiz-Julien, A., & Chassagne, D. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802170p · Cited by 63 · see citing works
Chemical composition of the cell wall of probiotic and brewer’s yeast in response to cultivation medium with glycerol as a carbon source
Bzducha‐Wróbel, A., Kieliszek, M., & Błażejak, S. (2013) · European Food Research and Technology · doi:10.1007/s00217-013-2016-8 · Cited by 62 · see citing works
Loss of Function of KRE5 Suppresses Temperature Sensitivity of Mutants Lacking Mitochondrial Anionic Lipids
Zhong, Q., Gvozdenovic‐Jeremic, J., Webster, P. C., Zhou, J., & Greenberg, M. L. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-09-0808 · Cited by 63 · see citing works
BIONIC: biological network integration using convolutions
Forster, D. T., Li, S. C., Yashiroda, Y., Yoshimura, M., Li, Z., Isuhuaylas, L. A. V., Itto‐Nakama, K., Yamanaka, D., Ohya, Y., Osada, H., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01616-x · Cited by 56 · see citing works
The stress response protein Hsp12p increases the flexibility of the yeast Saccharomyces cerevisiae cell wall
Karreman, R. J., Dague, É., Gaboriaud, F., Quilès, F., Duval, J. F. L., & Lindsey, G. G. (2006) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2006.10.009 · Cited by 60 · see citing works
GAS2 and GAS4 , a Pair of Developmentally Regulated Genes Required for Spore Wall Assembly in Saccharomyces cerevisiae
Ragni, E., Coluccio, A. E., Rolli, E., Rodríguez-Peña, J. M., Colasante, G., Arroyo, J., Neiman, A. M., & Popolo, L. (2006) · Eukaryotic Cell · doi:10.1128/ec.00321-06 · Cited by 59 · see citing works
Regulation of expression, activity and localization of fungal chitin synthases
Rogg, L. E., Fortwendel, J. R., Juvvadi, P. R., & Steinbach, W. J. (2011) · Medical Mycology · doi:10.3109/13693786.2011.577104 · Cited by 59 · see citing works
Candida albicans cell wall comprises a branched β-d-(1→6)-glucan with β-d-(1→3)-side chains
Iorio, E., Torosantucci, A., Bromuro, C., Chiani, P., Ferretti, A., Giannini, M., Cassone, A., & Podo, F. (2008) · Carbohydrate Research · doi:10.1016/j.carres.2008.02.020 · Cited by 58 · see citing works
A Novel Endoplasmic Reticulum Membrane Protein Rcr1 Regulates Chitin Deposition in the Cell Wall of Saccharomyces cerevisiae
Imai, K., Noda, Y., Adachi, H., & Yoda, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409428200 · Cited by 56 · see citing works
Response of yeast cells to high glucose involves molecular and physiological differences when compared to other osmostress conditions
Gomar‐Alba, M., Morcillo-Parra, M. Á., & del Olmo, M. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov039 · Cited by 53 · see citing works
Genetic Determinants of the Release of Mannoproteins of Enological Interest bySaccharomyces cerevisiae
González-Ramos, D., & Gonzalez, R. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062196d · Cited by 52 · see citing works
Induction of Cell Wall Thickening by the Antifungal Compound Dihydromaltophilin Disrupts Fungal Growth and is Mediated by Sphingolipid Biosynthesis
Li, S., Calvo, A. M., Yuen, G. Y., Du, L., & Harris, S. D. (2008) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2008.00384.x · Cited by 51 · see citing works
Transcriptome profiling of a Saccharomyces cerevisiae mutant with a constitutively activated Ras/cAMP pathway.
Jones, D. L., Petty, J., Hoyle, D., Hayes, A., Ragni, E., Popolo, L., Oliver, S., & Stateva, L. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00139.2003 · Cited by 51 · see citing works
Characterisation of CwpA, a putative glycosylphosphatidylinositol-anchored cell wall mannoprotein in the filamentous fungus Aspergillus niger
Damveld, R. A., Arentshorst, M., vanKuyk, P., Klis, F. M., van den Hondel, C. A. M. J. J., & Ram, A. F. J. (2005) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2005.06.006 · Cited by 48 · see citing works
Self-citation
Maintenance of cell integrity in the gas1 mutant of Saccharomyces cerevisiae requires the Chs3p‐targeting and activation pathway and involves an unusual Chs3p localization
Carotti, C., Ferrario, L., Roncero, C., Valdivieso, M. ‐., Durán, Á., & Popolo, L. (2002) · Yeast · doi:10.1002/yea.905 · Cited by 48 · see citing works
The β‐1,3‐glucanosyltransferase gas4p is essential for ascospore wall maturation and spore viability in Schizosaccharomyces pombe
de Medina-Redondo, M., Arnáiz‐Pita, Y., Fontaine, T., del Rey, F., Latgé, J., & de Aldana, C. R. V. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06233.x · Cited by 47 · see citing works
Identification of Aph1, a Phosphate-Regulated, Secreted, and Vacuolar Acid Phosphatase in Cryptococcus neoformans
Lev, S., Crossett, B., Cha, S. Y., Desmarini, D., Li, C., Chayakulkeeree, M., Wilson, C. F., Williamson, P. R., Sorrell, T. C., & Djordjevic, J. T. (2014) · mBio · doi:10.1128/mbio.01649-14 · Cited by 45 · see citing works
A GAS-like gene family in the pathogenic fungus Candida glabrata The EMBL accession numbers for the sequences reported in this paper are AJ302061 for CgGAS1, AJ302062 for CgGAS2 and AJ302063 for CgGAS3.
Weig, M., Haynes, K., Rogers, T. R., Kurzai, O., Frosch, M., & Mühlschlegel, F. A. (2001) · Microbiology · doi:10.1099/00221287-147-8-2007 · Cited by 46 · see citing works
The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo‐osmotic shock in Saccharomyces cerevisiae
Gualtieri, T., Ragni, E., Mizzi, L., Fascio, U., & Popolo, L. (2004) · Yeast · doi:10.1002/yea.1155 · Cited by 45 · see citing works
A large‐scale study of Yap1p‐dependent genes in normal aerobic and H2O2‐stress conditions: the role of Yap1p in cell proliferation control in yeast
Dumond, H., Danielou, N., Pinto, M., & Bolotin‐Fukuhara, M. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01845.x · Cited by 44 · see citing works
Iron Assimilation during Emerging Infections Caused by Opportunistic Fungi with emphasis on Mucorales and the Development of Antifungal Resistance
Stanford, F. A., & Voigt, K. (2020) · Genes · doi:10.3390/genes11111296 · Cited by 43 · see citing works
Influence of different yeast cell-wall mutants on performance and protection against pathogenic bacteria (Vibrio campbellii) in gnotobiotically-grown Artemia
Soltanian, S., Dhont, J., Sorgeloos, P., & Bossier, P. (2006) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2006.09.013 · Cited by 43 · see citing works
Physiologically relevant alternative carbon sources modulate biofilm formation, Cell Wall architecture, and the stress and antifungal resistance of Candida glabrata
Chew, S. Y., Ho, K. L., Cheah, Y. K., Sandai, D., Brown, A. J. P., & Than, L. T. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133172 · Cited by 40 · see citing works
Yeast Kre1p is GPI-anchored and involved in both cell wall assembly and architecture
Breinig, F. (2004) · Microbiology · doi:10.1099/mic.0.27175-0 · Cited by 42 · see citing works
Identification and Characterization of a Novel Issatchenkia orientalis GPI-Anchored Protein, IoGas1, Required for Resistance to Low pH and Salt Stress
Matsushika, A., Negi, K., Suzuki, T., Goshima, T., & Hoshino, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161888 · Cited by 42 · see citing works
Chitosan-mediated changes in cell wall composition, morphology and ultrastructure in two wood-inhabiting fungi
Vesentini, D., Steward, D., Singh, A. P., Ball, R. D., Daniel, G., & Franich, R. A. (2007) · Mycological Research · doi:10.1016/j.mycres.2007.05.015 · Cited by 42 · see citing works
Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes
Lara‐Aguilar, V., Rueda, C., García-Barbazán, I., Varona, S., Monzón, S., Jiménez, P., Cuesta, I., Zaballos, Á., & Zaragoza, Ó. (2021) · Virulence · doi:10.1080/21505594.2021.1927609 · Cited by 40 · see citing works
Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data
Okada, H., Ohnuki, S., Roncero, C., Konopka, J. B., & Ohya, Y. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-07-0396 · Cited by 41 · see citing works
Effect of yeast strain and fermentation conditions on the release of cell wall polysaccharides
Giovani, G., Canuti, V., & Rosi, I. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.12.009 · Cited by 40 · see citing works
Mass spectrometric quantitation of covalently bound cell wall proteins inSaccharomyces cerevisiae
Yin, Q. Y., de Groot, P. W. J., de Jong, L., Klis, F. M., & de Koster, C. G. (2007) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2007.00272.x · Cited by 40 · see citing works
Self-citation
Systematic Comparison of Cell Wall-Related Proteins of Different Yeasts
Lozančić, M., Žunar, B., Hrestak, D., Lopandić, K., Teparić, R., & Mrša, V. (2021) · Journal of Fungi · doi:10.3390/jof7020128 · Cited by 39 · see citing works
β(1,3)-Glucanosyl-Transferase Activity Is Essential for Cell Wall Integrity and Viability of Schizosaccharomyces pombe
de Medina-Redondo, M., Arnáiz-Pita, Y., Clavaud, C., Fontaine, T., del Rey, F., Latgé, J. P., & Vázquez de Aldana, C. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014046 · Cited by 39 · see citing works
The Saccharomyces SUN gene, UTH1 , is involved in cell wall biogenesis
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Authors: Ram, A. F. J., Kapteyn, J. C., Montijn, R. C., Caro, L. H. P., Douwes, J. E., Baginsky, W., Mazur, P., van den Ende, H., & Klis, F. M.
Affiliations: University of Amsterdam (NL)
Institute of Molecular Cell Biology, BioCentrum Amsterdam, University of Amsterdam, 1098 SM Amsterdam,1 and
Wageningen University & Research (NL)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
ORCID: Ram, Arthur F. J.
Douwes, Jeroen E.
Venue: Journal of Bacteriology
Publisher: American Society for Microbiology
Published: 1998-03-15
Volume: 180
Issue: 6
Pages: 1418-1424
ISSN: 0021-9193 (ISSN-L)
1098-5530
DOI: 10.1128/jb.180.6.1418-1424.1998
PMC: PMC107039
OpenAlex: W2152455126
Cited by: 200
References: 62
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 7
FWCI: 4.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Bacteriology (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: plasma membrane proteins, cell wall integrity, chitin, mannan, Saccharomyces cerevisiae
MeSH terms: Carbohydrates, Cell Wall, Chitin, Cloning, Molecular, DNA, Fungal, Fungal Proteins, Glucans, Glucosyltransferases, Glycoproteins, Mannans, Membrane Glycoproteins, Membrane Proteins, Plasmids, Recombination, Genetic, RNA, Fungal, Saccharomyces cerevisiae, Blotting, Western, Gene Expression, Polymerase Chain Reaction, Culture Media, Conditioned, Sequence Deletion, Saccharomyces cerevisiae Proteins, beta-Glucans, Carbohydrate Metabolism

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Loss of the Plasma Membrane-Bound Protein Gas1p in Saccharomyces cerevisiae Results in the Release of β1,3-Glucan into the Medium and Induces a Compensation Mechanism To Ensure Cell Wall Integrity

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