Recent Approaches to Antifungal Therapy for Invasive Mycoses

Mathew, Bijoy P.; Nath, Mahendra

doi:10.1002/cmdc.200800353

Cited by 105Antifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control

Recent Approaches to Antifungal Therapy for Invasive Mycoses

Mathew, Bijoy P., Nath, Mahendra·2009·ChemMedChem

DOI 10.1002/cmdc.200800353

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Abstract

Antimycotic agents: Diverse classes of antimycotic drugs have been developed over the past decades with the goal of improving selectivity and efficacy. This review discusses both conventional and novel targets for antifungal agents and the possibility of vaccination in the treatment of invasive fungal infections.magnified image Invasive fungal infections with primary and opportunistic mycoses have become increasingly common in recent years and pose a major diagnostic and therapeutic challenge. They represent a major area of concern in today's medical fraternity. The occurrence of invasive fungal diseases, particularly in AIDS and other immunocompromised patients, is life‐threatening and increases the economic burden. Apart from the previously known polyenes and imidazole‐based azoles, newly discovered triazoles and echinocandins are more effective in terms of specificity, yet some immunosuppressed hosts are difficult to treat. The main reasons for this include antifungal resistance, toxicity, lack of rapid and microbe‐specific diagnoses, poor penetration of drugs into sanctuary sites, and lack of oral or intravenous preparations. In addition to combination antifungal therapy, other novel antimycotic treatments such as calcineurin signaling pathway blockers and vaccines have recently emerged. This review briefly summarizes recent developments in the pharmacotherapeutic treatment of invasive fungal infections.

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Only few classes of antifungal agents are currently available to treat mucosal or systemic infections with Candida spp.
“Although the antifungal drugs used in clinical treatments appear to be diverse and numerous, only few classes of antifungal agents are currently available to treat mucosal or systemic infections with Candida spp. (Figure 1) [18–20].”
From CandidaInfections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [18]

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Bacterial-Fungal Interactions: Hyphens between Agricultural, Clinical, Environmental, and Food Microbiologists
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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity
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Novel antifungal agents: a patent review (2011 – present)
Castelli, M. V., Butassi, E., Monteiro, M. C., Svetaz, L. A., Vicente, F., & Zacchino, S. A. (2014) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.876993 · Cited by 72 · see citing works
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Additional file 6 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650796
Additional file 7 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650799
Additional file 1 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650781
Additional file 4 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650790
Additional file 5 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650793
Additional file 8 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650802
Additional file 2 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650784
Additional file 3 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Chen, G., Wang, M., Ni, X., & Xia, H. (2021) · Figshare · doi:10.6084/m9.figshare.14650787

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Authors: Mathew, B. P., & Nath, M.
Affiliations: University of Delhi (IN)
ORCID: Mathew, Bijoy P.
Nath, Mahendra
Venue: ChemMedChem
Publisher: Wiley
Published: 2009-03-11
Volume: 4
Issue: 3
Pages: 310-323
ISSN: 1860-7179 (ISSN-L)
1860-7187
DOI: 10.1002/cmdc.200800353
OpenAlex: W2006545774
Cited by: 105
References: 144
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 13 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 12 · 2012: 10
FWCI: 1.49
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: ChemMedChem (publishedVersion)
PubMed (publishedVersion)
Funders: Council of Scientific and Industrial Research, India
University of Delhi
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: antifungal therapy, invasive fungal infections, opportunistic mycoses, polyenes, triazoles, echinocandins, antifungal resistance, immunocompromised patients, antifungal vaccines, combination antifungal therapy, drug toxicity
MeSH terms: Antifungal Agents, Azoles, Humans, Mycoses, Polyenes, Vaccination, Calcineurin, Echinocandins

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