The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.
Open accessAbstract
Catenins mediate the linkage of classical cadherins with actin microfilaments and are part of a higher order protein structure by which cadherins are connected to other cytoplasmic and transmembrane proteins. The ratio of actin-bound to free cadherin-catenin complex, which varies depending on the type and growth rate of cells, is thought to be altered by cellular signals, such as those associated with mitosis, polarization of cells and growth factors during development. EGF induces an immediate tyrosine phosphorylation of beta-catenin and gamma-catenin (plakoglobin). We show here an association of the EGF-receptor with the cadherin-catenin complex. Using recombinant proteins we demonstrate the interaction of EGF-receptor and beta-catenin in in vitro kinase assays. This interaction is mediated by the evolutionarily conserved central "core" region of beta-catenin. These results suggest that catenins represent an important link between EGF-induced signal transduction and cadherin function.
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Citations
Cites
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930
Self-citation
Cited by
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Mengaud, J., Ohayon, H., Gounon, P., Mège, R.-M., & Cossart, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81070-3 · Cited by 870
Regulation of Cadherin Adhesive Activity
Gumbiner, B. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.399 · Cited by 787
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
Jeanes, A., Gottardi, C. J., & Yap, A. S. (2008) · Oncogene · doi:10.1038/onc.2008.343 · Cited by 772
Metadata
- Authors
- Hoschuetzky, H., Aberle, H., & Kemler, R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1994-12-01
- Volume
- 127
- Issue
- 5
- Pages
- 1375-1380
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2122829982
- Cited by
- 711
- References
- 1
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Hoschuetzky, H., Aberle, H., & Kemler, R. (1994). Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. The Journal of cell biology. https://doi.org/10.1083/jcb.127.5.1375
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
