The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.
Open accessAbstract
Using antipeptide antibodies to conserved regions of the kinesin motor domain, we cloned a kinesin-related protein that associates with the centromere region of mitotic chromosomes. We call the protein MCAK, for mitotic centromere-associated kinesin. MCAK appears concentrated on centromeres at prophase and persists until telophase, after which time the localization disperses. It is found throughout the centromere region and between the kinetochore plates of isolated mitotic CHO chromosomes, in contrast to two other kinetochore-associated microtubule motors: cytoplasmic dynein and CENP-E (Yen et al., 1992), which are closer to the outer surface of the kinetochore plates. Sequence analysis shows MCAK to be a kinesin-related protein with the motor domain located in the center of the protein. It is 60-70% similar to kif2, a kinesin-related protein originally cloned from mouse brain with a centrally located motor domain (Aizawa et al., 1992). MCAK protein is present in interphase and mitotic CHO cells and is transcribed as a single 3.4-kb message.
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Cites
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Cited by
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Desai, A., Verma, S., Mitchison, T. J., & Walczak, C. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80960-5 · Cited by 708
Self-citationProliferation of aneuploid human cells is limited by a p53-dependent mechanism
Thompson, S. L., & Compton, D. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200905057 · Cited by 494
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends
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Aurora B is enriched at merotelic attachment sites, where it regulates MCAK
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Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
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Fission yeast pkl1 is a kinesin-related protein involved in mitotic spindle function.
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Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity
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Microtubule-depolymerizing kinesins
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Self-citationLucky 13-microtubule depolymerisation by kinesin-13 motors
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Mechanism and regulation of kinesin motors.
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Motility of Dimeric Ncd on a Metal-Chelating Surfactant: Evidence That Ncd Is Not Processive
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Metadata
- Authors
- Wordeman, L., & Mitchison, T. J.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-01-01
- Volume
- 128
- Issue
- 1
- Pages
- 95-104
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2150287123
- Cited by
- 382
- References
- 6
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- green
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