Synaptic Cell Adhesion

Missler, M.; Sudhof, T. C.; Biederer, T.

doi:10.1101/cshperspect.a005694

Cited by 255Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersCell Adhesion Molecules Research

Synaptic Cell Adhesion

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Missler, M., Sudhof, T. C., Biederer, T.·2012·Cold Spring Harbor Perspectives in Biology

DOI 10.1101/cshperspect.a005694PMC PMC3312681

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Abstract

Chemical synapses are asymmetric intercellular junctions that mediate synaptic transmission. Synaptic junctions are organized by trans-synaptic cell adhesion molecules bridging the synaptic cleft. Synaptic cell adhesion molecules not only connect pre- and postsynaptic compartments, but also mediate trans-synaptic recognition and signaling processes that are essential for the establishment, specification, and plasticity of synapses. A growing number of synaptic cell adhesion molecules that include neurexins and neuroligins, Ig-domain proteins such as SynCAMs, receptor phosphotyrosine kinases and phosphatases, and several leucine-rich repeat proteins have been identified. These synaptic cell adhesion molecules use characteristic extracellular domains to perform complementary roles in organizing synaptic junctions that are only now being revealed. The importance of synaptic cell adhesion molecules for brain function is highlighted by recent findings implicating several such molecules, notably neurexins and neuroligins, in schizophrenia and autism.

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There is increasing evidence that neurexins, neuroligins and LRR transmembrane proteins are involved in activity-dependent programs that modulate synapse function.
“There is increasing evidence for the involvement of neurexins, neuroligins and LRR transmembrane proteins in activity-dependent programs that modulate synapse function.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [16]
Neurexins bind other postsynaptic transmembrane proteins, including LRR transmembrane proteins, in addition to neuroligins, increasing the number of potential trans-synaptic connections.
“In addition to binding neuroligins, neurexins bind other postsynaptic transmembrane proteins, including leucine-rich repeat (LRR) transmembrane proteins, adding to the number of different potential trans-synaptic connections16.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [16]
Particular neuroligin family members localize specifically to inhibitory or excitatory synapses, suggesting individual neuroligins may specify the formation or function of excitatory and inhibitory synapses.
“Particular neuroligin family members are localized specifically to inhibitory or excitatory synapses, suggesting that individual neuroligins may play a part in specifying the formation or function of excitatory and inhibitory synapses.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [16]
Neuroligins are postsynaptic membrane proteins that function as neurexin receptors and, together with neurexins, modulate synapse formation and function.
“Neuroligins are postsynaptic membrane proteins that function as neurexin receptors and, working together with neurexins, modulate the formation and function of synapses16,37.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [16]

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Synaptic Imbalance, Stereotypies, and Impaired Social Interactions in Mice with Altered Neuroligin 2 Expression
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CASK and Protein 4.1 Support F-actin Nucleation on Neurexins
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Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission
Li, J., Ashley, J., Budnik, V., & Bhat, M. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.002 · Cited by 171 · see citing works
TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses
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β1-Integrins Are Required for Hippocampal AMPA Receptor-Dependent Synaptic Transmission, Synaptic Plasticity, and Working Memory
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Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.
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Synaptically Targeted Narp Plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons
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Distinct Roles of the β1-Class Integrins at the Developing and the Mature Hippocampal Excitatory Synapse
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Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions
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Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+Channels
Zhang, W., Rohlmann, A., Sargsyan, V., Aramuni, G., Hammer, R. E., Südhof, T. C., & Missler, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0497-05.2005 · Cited by 156 · see citing works
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γ-Protocadherins Are Targeted to Subsets of Synapses and Intracellular Organelles in Neurons
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Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases
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A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system☆☆Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under Accession Nos. AY182024 (human LRRTM1), AY182026 (human LRRTM2), AY182028 (human LRRTM3), AY182030 (human LRRTM4), AY182025 (mouse LRRTM1), AY182027 (mouse LRRTM2), AY182029 (mouse LRRTM3), and AY182031 (mouse LRRTM4).
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Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions
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SALM Synaptic Cell Adhesion-like Molecules Regulate the Differentiation of Excitatory Synapses
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The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
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Bergmann Glia and the Recognition Molecule CHL1 Organize GABAergic Axons and Direct Innervation of Purkinje Cell Dendrites
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The Calsyntenins—A Family of Postsynaptic Membrane Proteins with Distinct Neuronal Expression Patterns
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Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules
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NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex
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Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivo
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Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin
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N-Cadherin Transsynaptically Regulates Short-Term Plasticity at Glutamatergic Synapses in Embryonic Stem Cell-Derived Neurons
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Functional dependence of neuroligin on a new non-PDZ intracellular domain
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Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
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Morphological Characterization of Molecular Complexes Present in the Synaptic Cleft
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Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
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Distinct Roles of Different Neural Cell Adhesion Molecule (NCAM) Isoforms in Synaptic Maturation Revealed by Analysis of NCAM 180 kDa Isoform-Deficient Mice
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Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
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Neuroligin 2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction
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Neurexophilins Form a Conserved Family of Neuropeptide-Like Glycoproteins
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Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components
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Cell–cell interactions in synaptogenesis
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Identification of functional marker proteins in the mammalian growth cone
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Neurexin-Neuroligin Transsynaptic Interaction Mediates Learning-Related Synaptic Remodeling and Long-Term Facilitation in Aplysia
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LG/LNS domains: multiple functions – one business end?
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Postsynaptic EphrinB3 Promotes Shaft Glutamatergic Synapse Formation
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Modulation of synaptic transmission and plasticity by cell adhesion and repulsion molecules
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Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions
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SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones
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The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules
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The Structure of Neurexin 1α Reveals Features Promoting a Role as Synaptic Organizer
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N-Glycosylation at the SynCAM (Synaptic Cell Adhesion Molecule) Immunoglobulin Interface Modulates Synaptic Adhesion
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A real‐time analysis of growth cone–target cell interactions during the formation of stable contacts between hippocampal neurons in culture
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The SALM Family of Adhesion-like Molecules Forms Heteromeric and Homomeric Complexes
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Neuronal Pentraxins Mediate Silent Synapse Conversion in the Developing Visual System
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The neurexin superfamily of Caenorhabditis elegans
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Expression and functional characterization of LRRC4, a novel brain‐specific member of the LRR superfamily
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Presynaptic Targeting of α4β2 Nicotinic Acetylcholine Receptors Is Regulated by Neurexin-1β
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SynCAM1 expression correlates with restoration of central synapses on spinal motoneurons after two different models of peripheral nerve injury
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The resilient synapse: insights from genetic interference of synaptic cell adhesion molecules
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Selective Targeting of Different Neural Cell Adhesion Molecule Isoforms during Motoneuron–Myotube Synapse Formation in Culture and the Switch from an Immature to Mature Form of Synaptic Vesicle Cycling
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Authors: Missler, M., Sudhof, T. C., & Biederer, T.
Affiliations: University of Münster (DE)
Yale University (US)
Corresponding author: Biederer, T.
ORCID: Missler, M.
Biederer, T.
Venue: Cold Spring Harbor Perspectives in Biology
Publisher: Cold Spring Harbor Laboratory
Published: 2012-01-25
Volume: 4
Issue: 4
Pages: a005694-a005694
ISSN: 1943-0264 (ISSN-L)
DOI: 10.1101/cshperspect.a005694
PMC: PMC3312681
OpenAlex: W2150909590
Cited by: 255
References: 151
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Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Simons Foundation
Deutsche Forschungsgemeinschaft (SFB 492)
National Institutes of Health (MH052804)
National Institute of Mental Health (R01MH089054, R37MH052804)
National Institute on Drug Abuse (R01DA018928)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: synaptic cell adhesion molecules, chemical synapses, synaptic transmission, neurexin, neuroligins, receptor tyrosine kinase, receptor tyrosine phosphatase, leucine-rich repeat proteins, synaptic plasticity, schizophrenia, autism spectrum disorder
MeSH terms: Cell Adhesion, Humans, Ligands, Synapses, Signal Transduction, Cadherins

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Synaptic Cell Adhesion

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