Cited by 374Neuroscience and Neuropharmacology ResearchCell Adhesion Molecules ResearchGenetics and Neurodevelopmental Disorders

Synaptic adhesion molecules

Yamagata, Masahito, Sanes, Joshua R, Weiner, Joshua A·2003·Current Opinion in Cell Biology

Abstract

Formation, differentiation and plasticity of synapses, the specialized cell-cell contacts through which neurons communicate, all require interactions between pre- and post-synaptic partners. Several synaptically localized adhesion molecules potentially capable of mediating these interactions have been identified recently. Functional studies suggest roles for some of them in target recognition (e.g. SYG-1 and sidekicks), formation and alignment of synaptic specializations (e.g. SynCAM, neuroligin and neurexin), and regulation of synaptic structure and function (e.g. cadherins and syndecan).

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Crossref · 10.1016/s0955-0674(03)00107-8

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96 of 96 references verified0 citation errors · 0 not checkable

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  • Specific molecules, such as SYG-1 and sidekicks, are essential for cellular target recognition, while syndecans regulate synaptic structure and function.

    “Specific molecules, such as SYG-1 and sidekicks, are essential for cellular target recognition, while syndecans regulate synaptic structure and function [76].”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [76]

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Authors
Yamagata, M., Sanes, J. R., & Weiner, J. A.
Affiliations
Washington University in St. Louis (US)
Corresponding author
  • Yamagata, Masahito
  • Sanes, Joshua R
  • Weiner, Joshua A
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2003-10
Volume
15
Issue
5
Pages
621-632
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2067561211
Cited by
374
References
98
Citations by year
2026: 12 · 2025: 10 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 4 · 2020: 17 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 17 · 2012: 11
FWCI
2.64
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
synaptic adhesion molecules, synaptogenesis, synaptic plasticity, target recognition, side kick, neuroligins, neurexin, cadherins, syndecans, synaptic specializations
MeSH terms
Amino Acid Sequence, Animals, Axons, Cytoskeleton, Immunoglobulins, Nerve Tissue Proteins, Synaptic Transmission, Synapses, Synaptic Vesicles, Cell Adhesion Molecules, Cadherins, Protein Structure, Tertiary, Neural Cell Adhesion Molecules, GTP-Binding Proteins, Caenorhabditis elegans Proteins

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