Synaptic adhesion molecules
Abstract
Formation, differentiation and plasticity of synapses, the specialized cell-cell contacts through which neurons communicate, all require interactions between pre- and post-synaptic partners. Several synaptically localized adhesion molecules potentially capable of mediating these interactions have been identified recently. Functional studies suggest roles for some of them in target recognition (e.g. SYG-1 and sidekicks), formation and alignment of synaptic specializations (e.g. SynCAM, neuroligin and neurexin), and regulation of synaptic structure and function (e.g. cadherins and syndecan).
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Specific molecules, such as SYG-1 and sidekicks, are essential for cellular target recognition, while syndecans regulate synaptic structure and function.
“Specific molecules, such as SYG-1 and sidekicks, are essential for cellular target recognition, while syndecans regulate synaptic structure and function [76].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [76]
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- Authors
- Yamagata, M., Sanes, J. R., & Weiner, J. A.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Yamagata, Masahito
- Sanes, Joshua R
- Weiner, Joshua A
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 15
- Issue
- 5
- Pages
- 621-632
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2067561211
- Cited by
- 374
- References
- 98
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 4 · 2020: 17 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 17 · 2012: 11
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synaptic adhesion molecules, synaptogenesis, synaptic plasticity, target recognition, side kick, neuroligins, neurexin, cadherins, syndecans, synaptic specializations
- MeSH terms
- Amino Acid Sequence, Animals, Axons, Cytoskeleton, Immunoglobulins, Nerve Tissue Proteins, Synaptic Transmission, Synapses, Synaptic Vesicles, Cell Adhesion Molecules, Cadherins, Protein Structure, Tertiary, Neural Cell Adhesion Molecules, GTP-Binding Proteins, Caenorhabditis elegans Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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