pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells
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The interaction between late endocytic structures and microtubules in polarized cells was studied using a procedure previously shown to cause microtubule-dependent redistribution of lysosomes in fibroblasts and macrophages (Heuser, J. 1989. J. Cell Biol. 108:855-864). In cultured rat hippocampal neurons, low cytoplasmic pH caused cation-independent mannose-6-phosphate receptor-enriched structures to move out of the cell body and into the processes. In filter grown MDCK cells lowering the cytosolic pH to approximately 6.5 caused late endosomes to move to the base of the cell and this process was shown to be microtubule dependent. Alkalinization caused a shift in distribution towards the apical pole of the cell. The results are consistent with low pH causing the redistribution of late endosomes towards the plus ends of the microtubules. In MDCK cells the microtubules orientated vertically in the cell may play a role in this process. The shape changes that accompanied the redistribution of the late endosomes in MDCK cells were examined by electron microscopy. On low pH treatment fragmentation of the late endosomes was observed whereas after microtubule depolymerization individual late endosomal structures appeared to fuse together. The late endosomes of the MDCK cell appear to be highly pleomorphic and dependent on microtubules for their form and distribution in the cell.
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Activation of plus-end-directed movement at acidic pH is supported by experiments in which lysosomes and late endosomes move from the perinuclear region out to the periphery upon exposure of the cells to acidic buffers.
“Activation of plus-end–directed movement at acidic pH is supported by experiments in which lysosomes and late endosomes move from the perinuclear region out to the periphery upon exposure of the cells to acidic buffers (Heuser, 1989; Parton et al., 1991).”
From Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules (1998) · cites this paper as Parton et al., 1991
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Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993 · cited 1× · see citing works
“For example, in neuronal cells, which have been extensively studied as a model system for microtubule-dependent movement of organelles (Adams, 1982; Allen et al., 1982; Vale et al., 1985), the microtubules are organized into bundles of uniform polarity (Heidemann et al., 1981).”
BackgroundThe establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862 · see citing works
Self-citationPractical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,502 · see citing works
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110 · see citing works
Estimation of surface area from vertical sections
Baddeley, A. J., Gundersen, H. J. G., & Cruz-Orive, L. M. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb04282.x · Cited by 1,071 · see citing works
Cytoplasmic pH and free Mg2+ in lymphocytes.
RINK, T. J., Tsien, R. Y., & Pozzan, T. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.1.189 · Cited by 1,046 · see citing works
Intracellular transport in neurons.
Grafstein, B., & Forman, D. S. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1167 · Cited by 1,007 · see citing works
The mannose 6-phosphate receptor and the biogenesis of lysosomes
Griffiths, G. W., Hoflack, B., Simons, K., Mellman, I., & Kornfeld, S. A. (1988) · Cell · doi:10.1016/s0092-8674(88)80026-6 · Cited by 856 · see citing works
Self-citationBaas, P. W., Deitch, J. S., Black, M. M., & Banker, G. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8335 · Cited by 742 · see citing works
Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture
Banker, G. A. (1980) · Science · doi:10.1126/science.7403847 · Cited by 674 · see citing works
Microtubules and the endoplasmic reticulum are highly interdependent structures.
Terasaki, M., Chen, L. B., & Fujiwara, K. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.4.1557 · Cited by 642 · see citing works
Stereological methods. Vol. 1: Practical methods for biological morphometry
Hung, G. W. C. (1984) · Microchemical Journal · doi:10.1016/0026-265x(84)90124-3 · Cited by 631 · see citing works
Gruenberg, J. E., Griffiths, G. W., & Howell, K. E. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1301 · Cited by 586 · see citing works
Bacallao, R., Antony, C., Dotti, C., Karsenti, E., Stelzer, E. H., & Simons, K. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.6.2817 · Cited by 513 · see citing works
Self-citationTranslocation and clustering of endosomes and lysosomes depends on microtubules.
Matteoni, R., & Kreis, T. E. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.3.1253 · Cited by 497 · see citing works
Dynamic behavior of endoplasmic reticulum in living cells
Lee, C., & Chen, L. B. (1988) · Cell · doi:10.1016/0092-8674(88)90177-8 · Cited by 474 · see citing works
Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture
Dotti, C. G., & Simons, K. (1990) · Cell · doi:10.1016/0092-8674(90)90240-f · Cited by 427 · see citing works
Self-citationChanges in lysosome shape and distribution correlated with changes in cytoplasmic pH
Heuser, J. (1989) · The Journal of cell biology · doi:10.1083/jcb.108.3.855 · Cited by 390 · see citing works
Intracellular Transport Using Microtubule-Based Motors
Vale, R. D. (1987) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.03.110187.002023 · Cited by 364 · see citing works
Fast Axonal Transport in Squid Giant Axon
ALLEN, R. D., Metuzals, J., Tasaki, I., Brady, S. T., & Gilbert, S. P. (1982) · Science · doi:10.1126/science.6183744 · Cited by 350 · see citing works
Polarity orientation of axonal microtubules.
Heidemann, S. R., Landers, J. M., & Hamborg, M. A. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.661 · Cited by 349 · see citing works
Bartlett, W., & Banker, G. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-08-01944.1984 · Cited by 348 · see citing works
Bomsel, M., Parton, R. G., Kuznetsov, S. A., Schroer, T. A., & Gruenberg, J. E. (1990) · Cell · doi:10.1016/0092-8674(90)90117-w · Cited by 298 · see citing works
Self-citationRadial extension of macrophage tubular lysosomes supported by kinesin
Hollenbeck, P. J., & Swanson, J. A. (1990) · Nature · doi:10.1038/346864a0 · Cited by 295 · see citing works
Baas, P. W., Black, M. M., & Banker, G. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3085 · Cited by 295 · see citing works
Swanson, J. A., Bushnell, A. F., & Silverstein, S. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.1921 · Cited by 274 · see citing works
Endocytosis in filter-grown Madin-Darby canine kidney cells.
Bomsel, M., Prydz, K., Parton, R. G., Gruenberg, J. E., & Simons, K. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3243 · Cited by 261 · see citing works
Self-citationFleming, T. P., & Johnson, M. H. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002331 · Cited by 256 · see citing works
Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles.
Geuze, H. J., Stoorvogel, W., Strous, G. J., Slot, J. W., Zijderhand-Bleekemolen, J. E., & Mellman, I. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.6.2491 · Cited by 243 · see citing works
Achler, C., Filmer, D., Merte, C., & Drenckhahn, D. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.179 · Cited by 242 · see citing works
Reclustering of scattered Golgi elements occurs along microtubules.
Ho, W. C., Allan, V., Gerrit van, M. E. E. R., Berger, E. G., & Kreis, T. E. (1989) · PubMed · Cited by 229 · see citing works
Microtubules, membrane traffic, and cell organization
Kelly, R. B. (1990) · Cell · doi:10.1016/0092-8674(90)90206-t · Cited by 228 · see citing works
Cooper, M. S., Cornell-Bell, A. H., Chernjavsky, A., Dani, J. W., & Smith, S. J. (1990) · Cell · doi:10.1016/0092-8674(90)90221-y · Cited by 228 · see citing works
Parton, R. G., Prydz, K., Bomsel, M., Simons, K., & Griffiths, G. W. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3259 · Cited by 222 · see citing works
Self-citationRindler, M. J., Ivanov, I. E., & Sabatini, D. D. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.2.231 · Cited by 213 · see citing works
Intracellular pH Regulation in Epithelial Cells
Boron, W. F. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.002113 · Cited by 202 · see citing works
Eilers, U., Klumperman, J., & Hauri, H. P. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.1.13 · Cited by 179 · see citing works
Intracellular pH Regulation in Epithelial Cells
Boron, W. F. (1986) · Annual Review of Physiology · doi:10.1146/annurev.physiol.48.1.377 · Cited by 165 · see citing works
Herman, B. A., & Albertini, D. F. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.2.565 · Cited by 157 · see citing works
Griffiths, G. W., Matteoni, R., Back, R., & Hoflack, B. (1990) · Journal of Cell Science · doi:10.1242/jcs.95.3.441 · Cited by 155 · see citing works
Brabander, M. D., Nuydens, R., Geerts, H., & Hopkins, C. R. (1988) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970090105 · Cited by 150 · see citing works
Buendia, B., Bré, M., Griffiths, G. W., & Karsenti, E. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1123 · Cited by 104 · see citing works
Plasticity of the tubular lysosomal compartment in macrophages
Knapp, P. E., & Swanson, J. A. (1990) · Journal of Cell Science · doi:10.1242/jcs.95.3.433 · Cited by 101 · see citing works
Mogensen, M. M., Tucker, J. B., & Stebbings, H. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1445 · Cited by 96 · see citing works
Kurtz, I., & Golchini, K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61222-0 · Cited by 92 · see citing works
Self-citationRecent progress on structural interactions of the endoplasmic reticulum
Terasaki, M. (1990) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970150203 · Cited by 87 · see citing works
Organelle movement in axons depends on ATP
Adams, R. J. (1982) · Nature · doi:10.1038/297327a0 · Cited by 85 · see citing works
van Deurs, B., Hansen, S. H., PETERSEN, O. W., Melby, E., & Sandvig, K. (1990) · PubMed · Cited by 61 · see citing works
Animal cell lysosomes rapidly exchange membrane proteins.
Deng, Y., & Storrie, B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3860 · Cited by 57 · see citing works
Gorbsky, G. J., & Borisy, G. G. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.6889 · Cited by 53 · see citing works
Formaldehyde-amine fixatives for immunocytochemistry of cultured Xenopus myocytes.
Luther, P. W., & Bloch, R. J. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.1.2491754 · Cited by 43 · see citing works
Aldehyde fixatives: Quantification of acid‐producing reactions
Johnson, T. J. A. (1985) · Journal of Electron Microscopy Technique · doi:10.1002/jemt.1060020204 · Cited by 34 · see citing works
Isolation of pig thyroid lysosomes. Biochemical and morphological characterization
Alquier, C., Guenin, P., Munari‐Silem, Y., Audebet, C., & Rousset, B. (1985) · Biochemical Journal · doi:10.1042/bj2320529 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rab11 regulates recycling through the pericentriolar recycling endosome.
Ullrich, O., Reinsch, S. S., Urbé, S., Zerial, M., & Parton, R. G. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.4.913 · Cited by 1,319 · see citing works
Self-citationHaass, C., Koo, E., Mellon, A., Hung, A. Y., & Selkoe, D. (1992) · Nature · doi:10.1038/357500a0 · Cited by 901 · see citing works
The endocytic pathway: a mosaic of domains
Gruenberg, J. E. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096054 · Cited by 703 · see citing works
Transcytosis: Crossing Cellular Barriers
TUMA, P. L., & HUBBARD, A. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00001.2003 · Cited by 681 · see citing works
The position of lysosomes within the cell determines their luminal pH
Johnson, D. E., Ostrowski, P., Jaumouillé, V., & Grinstein, S. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201507112 · Cited by 590 · see citing works
Mechanisms and functions of lysosome positioning
Pu, J., Guardia, C. M. A., Keren‐Kaplan, T., & Bonifacino, J. S. (2016) · Journal of Cell Science · doi:10.1242/jcs.196287 · Cited by 542 · see citing works
The Complex Ultrastructure of the Endolysosomal SystemPreprint
Klumperman, J., & Raposo, G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016857 · Cited by 391 · see citing works
Tardieux, I., Webster, P. C., Ravesloot, J. H., Boron, W. F., Lunn, J. A., Heuser, J. E., & Andrews, N. W. (1992) · Cell · doi:10.1016/s0092-8674(05)80061-3 · Cited by 387 · see citing works
Bayer, N., Schober, D., Prchla, E., Murphy, R. F., Blaas, D., & Fuchs, R. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9645-9655.1998 · Cited by 329 · see citing works
Phagosome dynamics during phagocytosis by neutrophils
Nordenfelt, P., & Tapper, H. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810457 · Cited by 325 · see citing works
Organization of organelles and membrane traffic by microtubules
Cole, N. B., & Lippincott‐Schwartz, J. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80045-x · Cited by 323 · see citing works
Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains
Puthenveedu, M., Lauffer, B. E. L., Temkin, P., Vistein, R., Carlton, P., Thorn, K., Taunton, J., Weiner, O., Parton, R., & von Zastrow, M. (2010) · Cell · doi:10.1016/j.cell.2010.10.003 · Cited by 332 · see citing works
Self-citationLysosomal Biology and Function: Modern View of Cellular Debris Bin
Trivedi, P., Bartlett, J., & Pulinilkunnil, T. (2020) · Cells · doi:10.3390/cells9051131 · Cited by 240 · see citing works
Cytoplasmic dynein participates in the centrosomal localization of the Golgi complex.
Corthésy-Theulaz, I. E., Pauloin, A., & Pfeffer, S. R. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.6.1333 · Cited by 281 · see citing works
Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules
Verhey, K. J., Lizotte, D. L., Abramson, T., Barenboim, L., Schnapp, B. J., & Rapoport, T. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1053 · Cited by 266 · see citing works
“Activation of plus-end–directed movement at acidic pH is supported by experiments in which lysosomes and late endosomes move from the perinuclear region out to the periphery upon exposure of the cells to acidic buffers (Heuser, 1989; Parton et al., 1991).”
Axonal and dendritic endocytic pathways in cultured neurons.
Parton, R. G., Simons, K., & Dotti, C. G. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.1.123 · Cited by 269 · see citing works
Self-citationPapillomaviruses infect cells via a clathrin-dependent pathway
Day, P. M., Lowy, D. R., & Schiller, J. T. (2003) · Virology · doi:10.1016/s0042-6822(02)00143-5 · Cited by 230 · see citing works
Molecular Requirements for Bi-directional Movement of Phagosomes Along Microtubules
Blocker, A., Severin, F. F., Burkhardt, J. K., Bingham, J. B., Yu, H., Olivo‐Marín, J., Schroer, T. A., Hyman, A. A., & Griffiths, G. W. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.113 · Cited by 229 · see citing works
Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends
Vaughan, K. T., Tynan, S. H., Faulkner, N. E., Echeverri, C. J., & Vallee, R. B. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.10.1437 · Cited by 210 · see citing works
Sloane, B. F., Moin, K., Sameni, M., Tait, L. R., Rozhin, J., & Ziegler, G. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.2.373 · Cited by 186 · see citing works
The role of lysosomes in cancer development and progression
Tang, T., Yang, Z., Wang, D., Yang, X., Wang, J., Li, L., Wen, Q., Gao, L., Bian, X., & Yu, S. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00489-x · Cited by 169 · see citing works
PtdIns3P controls mTORC1 signaling through lysosomal positioning
Hong, Z., Pedersen, N. M., Wang, L., Torgersen, M. L., Stenmark, H., & Raiborg, C. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611073 · Cited by 154 · see citing works
Kinesin-mediated organelle translocation revealed by specific cellular manipulations.
Feiguin, F. M., Ferreira, A., Kosik, K. S., & Cáceres, A. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.1021 · Cited by 151 · see citing works
Intraneuronal compartments of the amyloid precursor protein
Ferreira, A., Cáceres, A., & Kosik, K. S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03112.1993 · Cited by 140 · see citing works
Daro, E., Sheff, D. R., Gomez, M., Kreis, T. E., & Mellman, I. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1747 · Cited by 137 · see citing works
The Uptake of Mineral Particles by Pulmonary Epithelial Cells
Churg, A. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.4.8887617 · Cited by 131 · see citing works
Immunolocalization of cytoplasmic dynein to lysosomes in cultured cells
Lin, S. X. H., & Collins, C. A. (1992) · Journal of Cell Science · doi:10.1242/jcs.101.1.125 · Cited by 125 · see citing works
Acidification and Protein Traffic
Weisz, O. A. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)01005-2 · Cited by 122 · see citing works
LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
Filipek, P. A., de Araujo, M. E. G., Vogel, G. F., De Smet, C. H., Eberharter, D., Rebsamen, M., Rudashevskaya, E. L., Kremser, L., Yordanov, T., Tschaikner, P., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201703061 · Cited by 119 · see citing works
Microtubule-based peroxisome movement
Rapp, S., Saffrich, R., Anton, M., Jäkle, U., Ansorge, W. J., Gorgas, K., & Just, W. W. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.4.837 · Cited by 118 · see citing works
Burdick, D., Kosmoski, J. V., Knauer, M. F., & Glabe, C. G. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01262-0 · Cited by 112 · see citing works
The secretion of preformed granules by macrophages and neutrophils
Tapper, H. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.5.613 · Cited by 109 · see citing works
Steffan, J. J., Snider, J. L., Skalli, O., Welbourne, T., & Cardelli, J. A. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00904.x · Cited by 103 · see citing works
Microtubule-based membrane movement
Lane, J. D., & Allan, V. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(97)00010-5 · Cited by 102 · see citing works
Nanoparticle entry into cells; the cell biology weak link
Griffiths, G. W., Grüenberg, J., Marsh, M., Wohlmann, J., Jones, A. T., & Parton, R. G. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114403 · Cited by 99 · see citing works
Self-citationCLIPs for organellemicrotubule interactions
Rickard, J. E., & Kreis, T. E. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)10017-9 · Cited by 94 · see citing works
Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis
Roney, J. C., Cheng, X., & Sheng, Z. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202111077 · Cited by 87 · see citing works
Regulation of vesicle transport in CV-1 cells and extracts
Hamm‐Alvarez, S. F., Kim, P. Y., & Sheetz, M. P. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.3.955 · Cited by 86 · see citing works
Tapper, H., Furuya, W., & Grinstein, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5287 · Cited by 85 · see citing works
pH Microdomains in Oligodendrocytes
Ro, H.-A., & Carson, J. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403099200 · Cited by 83 · see citing works
Microtubule-associated protein-dependent binding of phagosomes to microtubules
Blocker, A., Severin, F. F., Habermann, A., Hyman, A. A., Griffiths, G., & Burkhardt, J. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3803 · Cited by 81 · see citing works
Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance
Lakpa, K. L., Khan, N., Afghah, Z., Chen, X., & Geiger, J. D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-09990-7 · Cited by 77 · see citing works
Acid incubation causes exocytic insertion of NHE3 in OKP cells
Yang, X., Amemiya, M., Peng, Y. S., Moe, O. W., Preisig, P. A., & Alpern, R. J. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.2.c410 · Cited by 78 · see citing works
Kao, L., Kurtz, L. M., Shao, X. M., Papadopoulos, M. C., Liu, L., Bok, D., Nusinowitz, S., Chen, B., Stella, S., Andre, M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.249961 · Cited by 73 · see citing works
Self-citationSantama, N., Krijnse‐Locker, J., Griffiths, G., Noda, Y., Hirokawa, N., & Dotti, C. G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.5855 · Cited by 74 · see citing works
Self-citationCell biology of neuronal endocytosis
Parton, R. G., & Dotti, C. G. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490360102 · Cited by 70 · see citing works
Self-citationProperties and regulation of ion channels in MDCK cells
Lang, F. J. W., & Paulmichl, M. (1995) · Kidney International · doi:10.1038/ki.1995.403 · Cited by 69 · see citing works
Henkel, J. R., Apodaca, G., Altschuler, Y., Hardy, S. F., & Weisz, O. A. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2477 · Cited by 62 · see citing works
Ashford, A. E. (1998) · Advances in botanical research · doi:10.1016/s0065-2296(08)60295-5 · Cited by 62 · see citing works
Majdi, A., Mahmoudi, J., Sadigh‐Eteghad, S., Golzari, S. E., Sabermarouf, B., & Reyhani‐Rad, S. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23757 · Cited by 60 · see citing works
Crossin, K. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11403 · Cited by 55 · see citing works
Ortega-Ramírez, A., Vega, R., & Soto, E. (2017) · Mediators of Inflammation · doi:10.1155/2017/3728096 · Cited by 54 · see citing works
Parton, R. G., Schrotz, P. C. U., Bucci, C., & Gruenberg, J. E. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.2.335 · Cited by 53 · see citing works
Self-citationMajumdar, D., & Bevensee, M. O. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.037 · Cited by 49 · see citing works
Cell polarity and epithelial oncogenesis
Schoenenberger, C., & Matlin, K. S. (1991) · Trends in Cell Biology · doi:10.1016/0962-8924(91)90035-8 · Cited by 46 · see citing works
Motor protein independent binding of endocytic carrier vesicles to microtubules in vitro.
Scheel, J., & Kreis, T. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55247-9 · Cited by 46 · see citing works
Halcrow, P. W., Lakpa, K. L., Khan, N., Afghah, Z., Miller, N., Datta, G., Chen, X., & Geiger, J. D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-09995-2 · Cited by 42 · see citing works
Henkel, J. R., Gibson, G. A., Poland, P. A., Ellis, M. A., Hughey, R. P., & Weisz, O. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.495 · Cited by 40 · see citing works
Gerrit van, M. E. E. R., & Hof, W. V. ’. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.3.833 · Cited by 40 · see citing works
Lysosome Dispersion in Osteoblasts Accommodates Enhanced Collagen Production during Differentiation
Nabavi, N., Urukova, Y., Cardelli, M., Aubin, J. E., & Harrison, R. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802517200 · Cited by 38 · see citing works
The internalization of a short acyl chain analogue of ganglioside GM1 in polarized neurons
Sofer, A., Schwarzmann, G., & Futerman, A. H. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.8.2111 · Cited by 38 · see citing works
van Deurs, B., von Bülow, F., Vilhardt, F., Holm, P. K., & Sandvig, K. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.7.1655 · Cited by 37 · see citing works
Recruitment of CG‐NAP to the Golgi apparatus through interaction with dynein–dynactin complex
Kim, H., Takahashi, M., Matsuo, K., & Ono, Y. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01055.x · Cited by 36 · see citing works
Deacidification of endolysosomes by neuronal aging drives synapse loss
Burrinha, T., Cunha, C., Hall, M. J., Lopes‐da‐Silva, M., Seabra, M. C., & Guimas Almeida, C. (2023) · Traffic · doi:10.1111/tra.12889 · Cited by 35 · see citing works
Ayala‐Sanmartín, J. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.4.753 · Cited by 35 · see citing works
Spatial regulation of mTORC1 signalling: Beyond the Rag GTPases
Carroll, B. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.02.007 · Cited by 34 · see citing works
Rajas, F., Gire, V., & Rousset, B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29882 · Cited by 31 · see citing works
Co-cultivation of rat pneumocytes and bovine endothelial cells on a liquid-air interface
Gueven, N., Glatthaar, B., Manke, H. G., & Haemmerle, H. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09050968 · Cited by 30 · see citing works
Nash, B., Tarn, K., Irollo, E., Luchetta, J., Festa, L. K., Halcrow, P. W., Datta, G., Geiger, J. D., & Meucci, O. (2019) · eNeuro · doi:10.1523/eneuro.0237-19.2019 · Cited by 30 · see citing works
Axons regulate the distribution of Schwann cell microtubules
Kidd, G. J., Andrews, S. B., & Trapp, B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00946.1996 · Cited by 29 · see citing works
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Mango, D., & Nisticò, R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.730641 · Cited by 28 · see citing works
Brewer, G. J. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815241 · Cited by 28 · see citing works
Atg5 regulates late endosome and lysosome biogenesis
Peng, J., Zhang, R., Cui, Y., Liu, H., Zhao, X., Huang, L. H., Hu, M., Yuan, X.-X., Ma, B., Ma, X., et al. (2013) · Science China Life Sciences · doi:10.1007/s11427-013-4588-8 · Cited by 27 · see citing works
Craig, A. M., Jareb, M., & Banker, G. A. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90025-g · Cited by 25 · see citing works
Mechanisms blocking microtubule minus end assembly: Evidence for a tubulin dimer-binding protein
Spittle, C. S., & Cassimeris, L. (1996) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1996)34:4 · Cited by 10 · see citing works
Pesaola, F. N., Quassollo, G., Venier, A. C., Paul, A. L. D., de Halac, I. N., & Bisbal, M. (2021) · Biology of the Cell · doi:10.1111/boc.202000016 · Cited by 19 · see citing works
pH regulation in non-neuronal brain cells and interstitial fluid
McAlear, S. D., & Bevensee, M. O. (2003) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)31032-x · Cited by 18 · see citing works
Neurotrophin signalling in the nervous system
Grimes, M. L., Zhou, J., Li, Y., Holtzman, D. M., & Mobley, W. C. (1993) · Seminars in Neuroscience · doi:10.1016/s1044-5765(05)80029-6 · Cited by 18 · see citing works
W(h)ither default? sorting and polarization in epithelial cells
Martin, K. S. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90081-m · Cited by 17 · see citing works
Extracellular Acidification Induces Lysosomal Dysregulation
Ordway, B., Gillies, R. J., & Damaghi, M. (2021) · Cells · doi:10.3390/cells10051188 · Cited by 16 · see citing works
Vascular Effects of ACE Inhibition by Perindopril
Michel, J., & Levy, B. I. (1990) · Drugs · doi:10.2165/00003495-199000391-00007 · Cited by 15 · see citing works
Putnam, R. W., & Roos, A. (1997) · Comprehensive physiology · doi:10.1002/cphy.cp140109 · Cited by 15 · see citing works
Exocytotic and endocytotic membrane traffic in neurons
Huttner, W. Β., & Dotti, C. G. (1991) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(91)90058-f · Cited by 14 · see citing works
Self-citationLow cytoplasmic pH reduces ER-Golgi trafficking and induces disassembly of the Golgi apparatus
Soonthornsit, J., Yamaguchi, Y., Tamura, D., Ishida, R., Nakakoji, Y., Osako, S., Yamamoto, A., & Nakamura, N. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.009 · Cited by 13 · see citing works
Nakanuma, Y., Hoso, M., Sanzen, T., & Sasaki, M. (1997) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19970915)38:6 · Cited by 282 · see citing works
Differential effects of cytotactin/tenascin fusion proteins on intracellular pH and cell morphology
Krushel, L. A., Prieto, A. L., Edelman, G. M., & Crossin, K. L. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041610314 · Cited by 11 · see citing works
Lee, D., Shin, D. M., & Hong, J. H. (2023) · Cells · doi:10.3390/cells12141835 · Cited by 10 · see citing works
Nair, S. V., Narendradev, N. D., Nambiar, R. P., Kumar, R., & Srinivasula, S. M. (2020) · Journal of Cell Science · doi:10.1242/jcs.239335 · Cited by 10 · see citing works
Endocytosis in the kidney: insights from the MDCK cell system.
Parton, R. G., & Simons, K. (1991) · PubMed · Cited by 10 · see citing works
Self-citationLow cytoplasmic pH causes fragmentation and dispersal of the Golgi apparatus in human hepatoma cells
Yoshida, T., Kamiya, T., Imanaka‐Yoshida, K., & Sakakura, T. (1999) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1999.00097.x · Cited by 9 · see citing works
[12] Manipulation and regulation ofcytosolic pH
Bevensee, M. O., & Boron, W. F. (1995) · Methods in neurosciences · doi:10.1016/s1043-9471(06)80015-7 · Cited by 8 · see citing works
Nabi, I. R., Guay, G., & Simard, D. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704501004 · Cited by 8 · see citing works
RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning
Trinh, L. T., Van Vu, A., Shin, S., Lee, C., Park, S.-H., Cho, E.-B., Heo, Y., Kim, H. J., Kim, S., & Yoon, J.-B. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116053 · Cited by 7 · see citing works
Nakayama, Y., Hisano, T., Okimoto, T., Tanaka, Y., Ishikawa, T., Himeno, M., Ono, M., & Kuwano, M. (1994) · Cell Structure and Function · doi:10.1247/csf.19.397 · Cited by 7 · see citing works
Out of the phagocyte or into its phagosome: signalling to secretion
Tapper, H. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb01363.x · Cited by 7 · see citing works
Mamais, A., Wallings, R. L., & Rocha, E. M. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85555-6.00009-6 · Cited by 6 · see citing works
Function of microtubules in protein secretion and organization of the Golgi complex
Saraste, J., & Thyberg, J. (1995) · The Cytoskeleton · doi:10.1016/s1874-6020(06)80021-2 · Cited by 5 · see citing works
Isoproterenol inhibits fluid-phase endocytosis from early to late endosomes
Sojakka, K., Punnonen, E., & Marjomäki, V. (1999) · European Journal of Cell Biology · doi:10.1016/s0171-9335(99)80095-8 · Cited by 4 · see citing works
Bogner, P., Skehan, P., Kenney, S., Sainz, E., Akeson, M. A., & Friedman, S. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.2.463 · Cited by 4 · see citing works
Patat, J., Schauer, K., & Lachuer, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1491304 · Cited by 3 · see citing works
- Authors
- Parton, R. G., Dotti, C. G., Bacallao, R., Kurtz, I., Simons, K., & Prydz, K.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1991-04-15
- Volume
- 113
- Issue
- 2
- Pages
- 261-274
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2288934
- OpenAlex
- W2051534134
- Cited by
- 115
- References
- 53
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2017: 3 · 2016: 3 · 2014: 2 · 2013: 1
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k11dk001777-05, 5r29dk039212-04)
- U.S. Public Health Service (A871013)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK39212, DK01777)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- late endosomes, microtubules, intracellular pH, mannose 6-phosphate receptor, lysosomes, hippocampal neurons, MDCK cells, epithelial cells, polarized cells, endosomal membrane fusion, microtubule depolymerization, endocytosis
- MeSH terms
- Animals, Cattle, Cell Line, Endocytosis, Epithelium, Hippocampus, Hydrogen-Ion Concentration, Kidney, Lysosomes, Microtubules, Neurons, Organelles, Rats
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