The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Coronin Promotes the Rapid Assembly and Cross-linking of Actin Filaments and May Link the Actin and Microtubule Cytoskeletons in Yeast
Open accessAbstract
Coronin is a highly conserved actin-associated protein that until now has had unknown biochemical activities. Using microtubule affinity chromatography, we coisolated actin and a homologue of coronin, Crn1p, from Saccharomyces cerevisiae cell extracts. Crn1p is an abundant component of the cortical actin cytoskeleton and binds to F-actin with high affinity (Kd 6 × 10−9 M). Crn1p promotes the rapid barbed-end assembly of actin filaments and cross-links filaments into bundles and more complex networks, but does not stabilize them. Genetic analyses with a crn1Δ deletion mutation also are consistent with Crn1p regulating filament assembly rather than stability. Filament cross-linking depends on the coiled coil domain of Crn1p, suggesting a requirement for Crn1p dimerization. Assembly-promoting activity is independent of cross-linking and could be due to nucleation and/or accelerated polymerization. Crn1p also binds to microtubules in vitro, and microtubule binding is enhanced by the presence of actin filaments. Microtubule binding is mediated by a region of Crn1p that contains sequences (not found in other coronins) homologous to the microtubule binding region of MAP1B. These activities, considered with microtubule defects observed in crn1Δ cells and in cells overexpressing Crn1p, suggest that Crn1p may provide a functional link between the actin and microtubule cytoskeletons in yeast.
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Cites
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Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Maniak, M., Rauchenberger, R., Albrecht, R., Murphy, J., & Gerisch, G. (1995) · Cell · doi:10.1016/0092-8674(95)90207-4 · Cited by 354
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Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis
Ho, C. T., Evans, E. B., Lukasik, K., O’Shaughnessy, E. C., Shah, A., Hsu, C.-H., Temple, B., Bear, J. E., & Gupton, S. L. (2025) · Journal of Cell Biology · doi:10.1083/jcb.202503068 · Cited by 1
Metadata
- Authors
- Goode, B. L., Wong, J. J., Butty, A.-C., Peter, M., McCormack, A. L., Yates, J. R., Drubin, D. G., & Barnes, G.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-01-11
- Volume
- 144
- Issue
- 1
- Pages
- 83-98
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2011014242
- Cited by
- 225
- References
- 2
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Coronin Promotes the Rapid Assembly and Cross-linking of Actin Filaments and May Link the Actin and Microtubule Cytoskeletons in Yeast. https://app.cochat.ai/papers/10.1083/jcb.144.1.83
- The paper
- Goode, B. L., Wong, J. J., Butty, A.-C., Peter, M., McCormack, A. L., Yates, J. R., Drubin, D. G., & Barnes, G. (1999). Coronin Promotes the Rapid Assembly and Cross-linking of Actin Filaments and May Link the Actin and Microtubule Cytoskeletons in Yeast. The Journal of Cell Biology. https://doi.org/10.1083/jcb.144.1.83
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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