CoChat
Sign Up
Cited by 1Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis

Open access
Ho, Chris T., Evans, Elliot B., Lukasik, Kimberly, O’Shaughnessy, Ellen C., Shah, Aneri, Hsu, Chih-Hsuan, Temple, Brenda, Bear, James E., Gupton, Stephanie L.·2025·Journal of Cell Biology
DOI 10.1083/jcb.202503068PMC PMC12614643

Published version of a preprint

Open this paper in CoChat — free account

Abstract

Neuronal morphogenesis depends on extracellular guidance cues accurately instructing intracellular cytoskeletal remodeling. Here, we describe a novel role of the actin binding protein coronin 1A (Coro1A) in neuronal morphogenesis, where it mediates responses to the axon guidance cue netrin-1. We found that Coro1A localizes to growth cones and filopodial structures and is required for netrin-dependent axon turning, branching, and corpus callosum development. We previously discovered that Coro1A interacts with TRIM67, a brain-enriched E3 ubiquitin ligase that binds the netrin receptor DCC, and is also required for netrin-mediated neuronal morphogenesis. Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A Coro1A mutant deficient in binding TRIM67 was unable to rescue loss of Coro1A phenotypes, indicating that the interaction between Coro1A and TRIM67 is required for netrin responses. Together, our findings reveal that Coro1A is required for proper neuronal morphogenesis, where it collaborates with TRIM67 downstream of netrin.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1083/jcb.202503068

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 119

  1. Appleton, 2006, The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes, Structure, 14, 87, 10.1016/j.str.2005.09.013 · DOI
  2. Asano, 2001, Coronin forms a stable dimer through its C-terminal coiled coil region: An implicated role in its localization to cell periphery, Genes Cells, 6, 225, 10.1046/j.1365-2443.2001.00416.x · DOI
  3. Askew, 2018, A story of birth and death: Insights into the formation and dynamics of the microglial population, Brain Behav. Immun., 69, 9, 10.1016/j.bbi.2017.03.009 · DOI
  4. Baba, 2018, Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance, Elife, 7, 10.7554/eLife.34593 · DOI
  5. Bastmeyer, 1996, Dynamics of target recognition by interstitial axon branching along developing cortical axons, J. Neurosci., 16, 1450, 10.1523/JNEUROSCI.16-04-01450.1996 · DOI
  6. Bin, 2015, Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death, Cell Rep., 12, 1099, 10.1016/j.celrep.2015.07.028 · DOI
  7. Blaker-Lee, 2012, Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes, Dis. Model. Mech., 5, 834, 10.1242/dmm.009944 · DOI
  8. Bodmer, 2012, Trafficking of Trk Receptors, 273, 10.1007/978-1-61779-824-5_16 · DOI
  9. Boyer, 2018, Revisiting Netrin-1: One Who Guides (Axons), Front. Cell. Neurosci., 12, 221, 10.3389/fncel.2018.00221 · DOI
  10. Boyer, 2020, A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance, J. Cell Biol., 219, 10.1083/jcb.201902088 · DOI
  11. Boyer, 2018, Mammalian TRIM67 Functions in Brain Development and Behavior, eNeuro, 5, ENEURO.0186-18.2018, 10.1523/ENEURO.0186-18.2018 · DOI
  12. Brieher, 2006, Rapid actin monomer–insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1, J. Cell Biol., 175, 315, 10.1083/jcb.200603149 · DOI
  13. Cai, 2005, Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility, J. Biol. Chem., 280, 31913, 10.1074/jbc.M504146200 · DOI
  14. Cai, 2007, F-actin binding is essential for coronin 1B function in vivo, J. Cell Sci., 120, 1779, 10.1242/jcs.007641 · DOI
  15. Cai, 2008, Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia, Cell, 134, 828, 10.1016/j.cell.2008.06.054 · DOI
  16. Cai, 2007, Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge, Cell, 128, 915, 10.1016/j.cell.2007.01.031 · DOI
  17. Chan, 2011, Unraveling the enigma: Progress towards understanding the coronin family of actin regulators, Trends Cell Biol., 21, 481, 10.1016/j.tcb.2011.04.004 · DOI
  18. Chan, 2012, Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin, Biochem. J., 444, 89, 10.1042/BJ20120209 · DOI
  19. Chen, 2014, Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton, J. Neurosci., 34, 2413, 10.1523/JNEUROSCI.3226-13.2014 · DOI
  20. Dema, 2024, Doublecortin reinforces microtubules to promote growth cone advance in soft environments, Curr. Biol., 34, 5822, 10.1016/j.cub.2024.10.063 · DOI
  21. Dent, 2004, Netrin-1 and Semaphorin 3A Promote or Inhibit Cortical Axon Branching, Respectively, by Reorganization of the Cytoskeleton, J. Neurosci., 24, 3002, 10.1523/JNEUROSCI.4963-03.2004 · DOI
  22. Dent, 2003, Cytoskeletal dynamics and transport in growth cone motility and axon guidance, Neuron, 40, 209, 10.1016/s0896-6273(03)00633-0 · DOI
  23. Dent, 2011, The growth cone cytoskeleton in axon outgrowth and guidance, Cold Spring Harb. Perspect. Biol., 3, a001800, 10.1101/cshperspect.a001800 · DOI
  24. Deshaies, 2009, RING domain E3 ubiquitin ligases, Annu. Rev. Biochem., 78, 399, 10.1146/annurev.biochem.78.101807.093809 · DOI · Paper page
  25. Dudley-Fraser, 2023, It’s a TRIM-endous view from the top: The varied roles of TRIpartite Motif proteins in brain development and disease, Front. Mol. Neurosci., 16, 1287257, 10.3389/fnmol.2023.1287257 · DOI
  26. Evans, 2022, Protein complex prediction with AlphaFold-Multimer, bioRxiv, 10.1101/2021.10.04.463034 · DOI · Paper page
  27. Fazeli, 1997, Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene, Nature, 386, 796, 10.1038/386796a0 · DOI
  28. Flores, 2011, Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system, J. Psychiatry Neurosci., 36, 296, 10.1503/jpn.100171 · DOI
  29. Flynn, 2012, ADF/Cofilin-mediated actin retrograde flow directs neurite formation in the developing brain, Neuron, 76, 1091, 10.1016/j.neuron.2012.09.038 · DOI
  30. Föger, 2006, Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis, Science, 313, 839, 10.1126/science.1130563 · DOI
  31. Gallo, 2011, The cytoskeletal and signaling mechanisms of axon collateral branching, Dev. Neurobiol., 71, 201, 10.1002/dneu.20852 · DOI
  32. Gandhi, 2009, Coronin switches roles in actin disassembly depending on the nucleotide state of actin, Mol. Cell, 34, 364, 10.1016/j.molcel.2009.02.029 · DOI
  33. Gatfield, 2005, Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules, Mol. Biol. Cell, 16, 2786, 10.1091/mbc.e05-01-0042 · DOI
  34. Glasgow, 2018, Activity-dependent netrin-1 secretion drives synaptic insertion of GluA1-containing AMPA receptors in the hippocampus, Cell Rep., 25, 168, 10.1016/j.celrep.2018.09.028 · DOI
  35. Goldman, 2013, Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly, J. Neurosci., 33, 17278, 10.1523/JNEUROSCI.1085-13.2013 · DOI
  36. Goode, 1999, Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast, J. Cell Biol., 144, 83, 10.1083/jcb.144.1.83 · DOI
  37. Grogan, 1997, Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils, J. Cell Sci., 110, 3071, 10.1242/jcs.110.24.3071 · DOI
  38. Han, 2023, The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization, Cell Rep., 42, 112594, 10.1016/j.celrep.2023.112594 · DOI
  39. Hao, 2010, The Tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in netrin-mediated axon attraction and branching, Dev. Cell, 18, 950, 10.1016/j.devcel.2010.02.019 · DOI
  40. Ho, 2021, Neurons | Establishing and Maintaining Neuron Morphology, 345, 10.1016/B978-0-12-819460-7.00240-1 · DOI
  41. de Hostos, 1991, Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits, EMBO J., 10, 4097, 10.1002/j.1460-2075.1991.tb04986.x · DOI
  42. Hoyer, 2018, A novel class of ER membrane proteins regulates ER-associated endosome fission, Cell, 175, 254, 10.1016/j.cell.2018.08.030 · DOI
  43. Humphries, 2002, Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin, J. Cell Biol., 159, 993, 10.1083/jcb.200206113 · DOI
  44. Hylton, 2022, Cofilactin filaments regulate filopodial structure and dynamics in neuronal growth cones, Nat. Commun., 13, 2439, 10.1038/s41467-022-30116-x · DOI · Paper page
  45. Iconomou, 2016, Systematic approaches to identify E3 ligase substrates, Biochem. J., 473, 4083, 10.1042/BCJ20160719 · DOI
  46. Jacquemet, 2023, Mapping the Localization of Proteins Within Filopodia Using FiloMap, 51, 10.1007/978-1-0716-2887-4_4 · DOI
  47. Jacquemet, 2019, Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability, Curr. Biol., 29, 202, 10.1016/j.cub.2018.11.053 · DOI
  48. Jansen, 2015, Single-molecule imaging of a three-component ordered actin disassembly mechanism, Nat. Commun., 6, 7202, 10.1038/ncomms8202 · DOI
  49. Jäntti, 2025, EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration, Dev. Cell, S1534-5807(25)00403-4, 10.1016/j.devcel.2025.06.025 · DOI
  50. Jayachandran, 2014, Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling, PLoS Biol., 12, 10.1371/journal.pbio.1001820 · DOI
  51. Kalil, 2014, Branch management: Mechanisms of axon branching in the developing vertebrate CNS, Nat. Rev. Neurosci., 15, 7, 10.1038/nrn3650 · DOI
  52. Kammerer, 2005, A conserved trimerization motif controls the topology of short coiled coils, Proc. Natl. Acad. Sci. USA, 102, 13891, 10.1073/pnas.0502390102 · DOI
  53. Ketschek, 2010, Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia, J. Neurosci., 30, 12185, 10.1523/JNEUROSCI.1740-10.2010 · DOI
  54. Kim, 2015, Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase, Mol. Cell. Biol., 35, 167, 10.1128/MCB.00857-14 · DOI
  55. King, 2022, Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover, J. Cell Biol., 221, 10.1083/jcb.202111126 · DOI
  56. Kizner, 2020, CRISPR/Cas9-mediated knockout of the neuropsychiatric risk gene KCTD13 causes developmental deficits in human cortical neurons derived from induced pluripotent stem cells, Mol. Neurobiol., 57, 616, 10.1007/s12035-019-01727-1 · DOI
  57. Kolodkin, 2011, Mechanisms and molecules of neuronal wiring: A primer, Cold Spring Harb. Perspect. Biol., 3, a001727, 10.1101/cshperspect.a001727 · DOI
  58. Korobova, 2008, Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells, Mol. Biol. Cell, 19, 1561, 10.1091/mbc.e07-09-0964 · DOI
  59. Koundinya, 2025, Two ligands of Arp2/3 complex, yeast coronin and GMF, interact and synergize in pruning branched actin networks, J. Biol. Chem., 301, 108191, 10.1016/j.jbc.2025.108191 · DOI
  60. Kubo, 2015, Shootin1–cortactin interaction mediates signal–force transduction for axon outgrowth, J. Cell Biol., 210, 663, 10.1083/jcb.201505011 · DOI
  61. Lebrand, 2004, Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of Netrin-1, Neuron, 42, 37, 10.1016/S0896-6273(04)00108-4 · DOI
  62. Lewis, 1992, Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity, J. Cell Biol., 119, 1219, 10.1083/jcb.119.5.1219 · DOI
  63. Lim, 2005, Parkin mediates nonclassical, proteasomal-independent ubiquitination of Synphilin-1: Implications for lewy body formation, J. Neurosci., 25, 2002, 10.1523/JNEUROSCI.4474-04.2005 · DOI · Paper page
  64. Lin, 2025, The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B, J. Cell Biol., 224, 10.1083/jcb.202407014 · DOI
  65. Liu, 2011, Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin, J. Biol. Chem., 286, 17039, 10.1074/jbc.M111.219964 · DOI
  66. Longair, 2011, Simple neurite tracer: Open source software for reconstruction, visualization and analysis of neuronal processes, Bioinformatics, 27, 2453, 10.1093/bioinformatics/btr390 · DOI
  67. Loo, 2019, Single-cell transcriptomic analysis of mouse neocortical development, Nat. Commun., 10, 134, 10.1038/s41467-018-08079-9 · DOI · Paper page
  68. Lowery, 2009, The trip of the tip: Understanding the growth cone machinery, Nat. Rev. Mol. Cell Biol., 10, 332, 10.1038/nrm2679 · DOI
  69. Machesky, 1997, Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins, Biochem. J., 328, 105, 10.1042/bj3280105 · DOI
  70. McArdle, 2008, Coronin structure and implications, Subcell. Biochem., 48, 56, 10.1007/978-0-387-09595-0_6 · DOI
  71. Mccormick, 2024, Loss of the E3 ubiquitin ligase TRIM67 alters the post-synaptic density proteome, MicroPubl. Biol., 2024, 10.17912/micropub.biology.001118, 10.17912/micropub.biology.001118 · DOI
  72. McCormick, 2024, The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1, Mol. Biol. Cell, 35, ar67, 10.1091/mbc.E23-12-0476 · DOI
  73. McCormick, 2020, Mechanistic advances in axon pathfinding, Curr. Opin. Cell Biol., 63, 11, 10.1016/j.ceb.2019.12.003 · DOI
  74. McCormick, 2024, Multi-monoubiquitylation controls VASP-mediated actin dynamics, J. Cell Sci., 137, jcs261527, 10.1242/jcs.261527 · DOI
  75. Menon, 2015, The E3 ubiquitin ligase TRIM9 Is a filopodia off switch required for netrin-dependent axon guidance, Dev. Cell, 35, 698, 10.1016/j.devcel.2015.11.022 · DOI
  76. Menon, 2021, The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis, Mol. Biol. Cell, 32, 314, 10.1091/mbc.E20-10-0622 · DOI · Paper page
  77. Meroni, 2005, TRIM/RBCC, a novel class of “single protein RING finger” E3 ubiquitin ligases, Bioessays., 27, 1147, 10.1002/bies.20304 · DOI
  78. Minamide, 2023, Visualizing cofilin-actin filaments by immunofluorescence and CryoEM: Essential steps for observing cofilactin in cells, Methods Mol. Biol., 2593, 265, 10.1007/978-1-0716-2811-9_18 · DOI
  79. Minegishi, 2021, Analyses of actin dynamics, clutch coupling and traction force for frowth cone advance, J. Vis. Exp., 10.3791/63227 · DOI
  80. Mishima, 1999, Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells, J. Cell Sci., 112, 2833, 10.1242/jcs.112.17.2833 · DOI
  81. Morikawa, 2011, Different levels of the tripartite motif protein, anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons, Proc. Natl. Acad. Sci. USA, 108, 19389, 10.1073/pnas.1109843108 · DOI
  82. Mutalik, 2025, TRIM9 controls growth cone responses to netrin through DCC and UNC5C, J. Neurochem., 169, 10.1111/jnc.70002 · DOI
  83. Nal, 2004, Coronin-1 expression in T lymphocytes: Insights into protein function during T cell development and activation, Int. Immunol., 16, 231, 10.1093/intimm/dxh022 · DOI
  84. Niarchou, 2019, Psychiatric disorders in children with 16p11.2 deletion and duplication, Transl. Psychiatry, 9, 8, 10.1038/s41398-018-0339-8 · DOI · Paper page
  85. Pachitariu, 2025, Cellpose-SAM: Superhuman generalization for cellular segmentation, bioRxiv, 10.1101/2025.04.28.651001 · DOI
  86. Plooster, 2017, TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching, Mol. Biol. Cell, 28, 2374, 10.1091/mbc.E16-08-0594 · DOI
  87. Pollard, 2009, Actin, a central player in cell shape and movement, Science, 326, 1208, 10.1126/science.1175862 · DOI
  88. Popović, 2023, Myosin-X recruits lamellipodin to filopodia tips, J. Cell Sci., 136, jcs260574, 10.1242/jcs.260574 · DOI
  89. Pucilowska, 2015, The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway, J. Neurosci., 35, 3190, 10.1523/JNEUROSCI.4864-13.2015 · DOI · Paper page
  90. Qiu, 2024, Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis, Front. Mol. Neurosci., 17, 1307755, 10.3389/fnmol.2024.1307755 · DOI
  91. Rodal, 2005, Conformational changes in the Arp2/3 complex leading to actin nucleation, Nat. Struct. Mol. Biol., 12, 26, 10.1038/nsmb870 · DOI
  92. Serafini, 1996, Netrin-1 Is required for commissural axon guidance in the developing vertebrate nervous system, Cell, 87, 1001, 10.1016/S0092-8674(00)81795-X · DOI
  93. Short, 2006, Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding, J. Biol. Chem., 281, 8970, 10.1074/jbc.M512755200 · DOI
  94. Sokolova, 2017, Structural basis of Arp2/3 complex inhibition by GMF, coronin, and arpin, J. Mol. Biol., 429, 237, 10.1016/j.jmb.2016.11.030 · DOI
  95. Spillane, 2012, Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex, J. Neurosci., 32, 17671, 10.1523/JNEUROSCI.1079-12.2012 · DOI
  96. Spillane, 2011, The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia, Dev. Neurobiol., 71, 747, 10.1002/dneu.20907 · DOI
  97. Spoerl, 2002, Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus, J. Biol. Chem., 277, 48858, 10.1074/jbc.M205136200 · DOI
  98. Stirling, 2021, CellProfiler 4: Improvements in speed, utility and usability, BMC Bioinformatics, 22, 433, 10.1186/s12859-021-04344-9 · DOI
  99. Stirnimann, 2010, WD40 proteins propel cellular networks, Trends Biochem. Sci., 35, 565, 10.1016/j.tibs.2010.04.003 · DOI
  100. Striepen, 2022, Coronin 1C restricts endosomal branched actin to organize ER contact and endosome fission, J. Cell Biol., 221, 10.1083/jcb.202110089 · DOI
  101. Suo, 2014, Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival, Nat. Neurosci., 17, 36, 10.1038/nn.3593 · DOI
  102. Suo, 2015, Coronin-1 and calcium signaling governs sympathetic final target innervation, J. Neurosci., 35, 3893, 10.1523/JNEUROSCI.4402-14.2015 · DOI
  103. Svitkina, 1999, Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in Lamellipodia, J. Cell Biol., 145, 1009, 10.1083/jcb.145.5.1009 · DOI
  104. Svitkina, 2003, Mechanism of filopodia initiation by reorganization of a dendritic network, J. Cell Biol., 160, 409, 10.1083/jcb.200210174 · DOI
  105. Taylor, 2015, Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients, Lab Chip, 15, 2781, 10.1039/c5lc00503e · DOI
  106. Thion, 2017, On place and time: microglia in embryonic and perinatal brain development, Curr. Opin. Neurobiol., 47, 121, 10.1016/j.conb.2017.10.004 · DOI
  107. Tocchini, 2015, TRIM-NHL proteins in development and disease, Semin. Cell Dev. Biol., 47, 52, 10.1016/j.semcdb.2015.10.017 · DOI
  108. Tsujita, 2010, Proteome of acidic phospholipid-binding proteins: Spatial and temporal regulation of Coronin 1A by phosphoinositides, J. Biol. Chem., 285, 6781, 10.1074/jbc.M109.057018 · DOI
  109. Uetrecht, 2006, Coronins: The return of the crown, Trends Cell Biol., 16, 421, 10.1016/j.tcb.2006.06.002 · DOI
  110. Urbina, 2021, TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47, Cell Rep., 34, 108743, 10.1016/j.celrep.2021.108743 · DOI
  111. Weiss, 2008, Association between microdeletion and microduplication at 16p11.2 and autism, N. Engl. J. Med., 358, 667, 10.1056/NEJMoa075974 · DOI · Paper page
  112. Winkle, 2014, A novel Netrin-1–sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching, J. Cell Biol., 205, 217, 10.1083/jcb.201311003 · DOI
  113. Winkle, 2016, Trim9 deletion alters the morphogenesis of developing and adult-born hippocampal neurons and impairs spatial learning and memory, J. Neurosci., 36, 4940, 10.1523/JNEUROSCI.3876-15.2016 · DOI
  114. Wolterink-Donselaar, 2009, A method for gender determination in newborn dark pigmented mice, Lab Anim., 38, 35, 10.1038/laban0109-35 · DOI
  115. Wong, 2019, Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain, Learn. Mem., 26, 77, 10.1101/lm.049072.118 · DOI · Paper page
  116. Wurm, 2021, Microglia development and maturation and its implications for induction of microglia-like cells from human iPSCs, Int. J. Mol. Sci., 22, 3088, 10.3390/ijms22063088 · DOI
  117. Yadav, 2017, TAOK2 kinase mediates PSD95 stability and dendritic spine maturation through Septin7 phosphorylation, Neuron, 93, 379, 10.1016/j.neuron.2016.12.006 · DOI
  118. Yang, 2012, Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow, J. Cell Biol., 197, 939, 10.1083/jcb.201111052 · DOI
  119. Yung, 2015, Phenotypic analysis of mice completely lacking netrin 1, Development, 142, 3686, 10.1242/dev.128942 · DOI

Metadata

Authors
Ho, C. T., Evans, E. B., Lukasik, K., O’Shaughnessy, E. C., Shah, A., Hsu, C.-H., Temple, B., Bear, J. E., & Gupton, S. L.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Gupton, Stephanie L.
ORCID
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2025-10-14
Volume
224
Issue
12
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.202503068
PMC
PMC12614643
OpenAlex
W4415192943
Cited by
1
References
6
Citations by year
2026: 1
FWCI
0.39
Type
journal article
Language
en
Open access
Licence
rupress.org/pages/terms102024 (vor)
Locations
  • The Journal of Cell Biology (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (submittedVersion)
Funders
  • National Institutes of Health (R35GM135160, R35GM130312)
  • American Heart Association (906429)
  • Cancer Center (P30 CA016086)
  • University of North Carolina
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
CORO1A, netrin-1, neuronal morphogenesis, axon guidance, actin-binding proteins, E3 ubiquitin ligase, DCC receptor, growth cones, filopodia, axon branching, corpus callosum development, cytoskeletal remodeling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review