The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression
Open accessAbstract
β-Catenin plays a pivotal role in the transcriptional activation of Wnt-responsive genes by binding to TCF/LEF transcription factors. Although it has been suggested that the COOH-terminal region of β-catenin functions as an activation domain, the mechanisms of activation remain unclear. To screen for potential transcriptional coactivators that bind to the COOH-terminal region of β-catenin, we used a novel yeast two-hybrid system, the Ras recruitment system (RRS) that detects protein–protein interactions at the inner surface of the plasma membrane. Using this system, we isolated the CREB-binding protein (CBP). Armadillo (Arm) repeat 10 to the COOH terminus of β-catenin is involved in binding to CBP, whereas β-catenin interacts directly with the CREB-binding domain of CBP. β-Catenin synergizes with CBP to stimulate the activity of a synthetic reporter in vivo. Conversely, β-catenin–dependent transcriptional activation is repressed by E1A, an antagonist of CBP function, but not by an E1A mutant that does not bind to CBP. The activation of Wnt target genes such as siamois and Xnr3 in Xenopus embryos is also sensitive to E1A. These findings suggest that CBP provides a link between β-catenin and the transcriptional machinery, and possibly mediates the oncogenic function of β-catenin.
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Cites
Identification of c- MYC as a Target of the APC Pathway
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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
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Phosphorylated CREB binds specifically to the nuclear protein CBP
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Self-citationMechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
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Self-citation
Cited by
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
Linking Colorectal Cancer to Wnt Signaling
Bienz, M., & Clevers, H. (2000) · Cell · doi:10.1016/s0092-8674(00)00122-7 · Cited by 1,515
Caught up in a Wnt storm: Wnt signaling in cancer
Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482
Metadata
- Authors
- Takemaru, K.-I., & Moon, R. T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-04-17
- Volume
- 149
- Issue
- 2
- Pages
- 249-254
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2158569397
- Cited by
- 473
- References
- 27
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- green
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